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Anxiolytics Ol 2002
1.
SEDATIVE/HYPNOTICS ANXIOLYTICS Martha
I. D ávila-García, Ph.D. Howard University Department of Pharmacology
2.
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5.
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22.
SEDATIVE/HYPNOTICS ANXYOLITICS GABAergic
SYSTEM
23.
24.
25.
26.
27.
Respiratory Depression Coma/
Anesthesia Ataxia Sedation Anxiolytic Anticonvulsant DOSE RESPONSE BARBS BDZs ETOH
28.
Respiratory Depression Coma/
Anesthesia Ataxia Sedation Anxiolytic Anticonvulsant DOSE RESPONSE BARBS BDZs
29.
GABAergic SYNAPSE GABA
glutamate glucose Cl - GAD
30.
31.
32.
Patch-Clamp Recording of
Single Channel GABA Evoked Currents From Katzung et al., 1996
33.
34.
35.
CNS Effects (Rate
of Onset) Lipid solubility
36.
37.
38.
Biotransformation of Benzodiazepines
From Katzung, 1998
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55.
56.
57.
58.
GABA ? NE
DA 5-HT ACh (-) (-) (-) (-) (-) ANXIOLYTIC ? SEDATION ? ANTICONVULSANT/ MUSCLE RELAXANT ?
59.
60.
61.
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