1. Drugs Affecting Urinary
System
Diuretics

2. Outlines:
1- Diuretics
A-Loop Diuretics → Furesmide (Lasix®)
B- Thiazides → Chlorothiazide (Diuril®)
C- Potassium Sparing Diuretics → Spironolactone (Aldactone®)
D- Osmotic Diuretics → Mannitol (Osmitrol®)
C- Carbonic Anhydrase Inhibitors → Acetazolamide (Diamox®)
2- Urinary antiseptics
- Ciprofluxacine HCl (Cipro®)
- Nitrofurantoin (Macrodantin®)
3- Urinary analgesic
Phenazopyredine

3. References:
•
Catherine Paradiso.1998 , Pharmacology. Lippincott’s. USA.
•
Bruce D. Clayton., Yvonne N. Stock.1997, Basic pharmacology for
nurses. 11th Ed, Mosby.USA.
•
Ben Greenstein., 2004 , Trounce’s Clinical Pharmacology for Nurses.
17th Ed, Churchill Livingstone.USA.
•
Brunner & Suddarth., 2004 , Medical-Surgical Nursing. 10th Ed,
Lippincott’s. USA.
•
http://en.wikipedia.org/wiki/Adenosine
•
Amy M. Karch., 2003 , Nursing Drug Guide. Lippincott’s. USA.

4. Diuretics
Cortex
Medulla
Loop of Henle
Thiazides
Inhibit active exchange of
Cl-Na
in the cortical diluting
segment of the
ascending loop of Henle
K-sparing
Inhibit reabsorption of
Na in the distal convoluted
and collecting tubule
Loop diuretics
Inhibit exchange of Cl-Na-K in
the thick segment of
the ascending loop of Henle
Collecting tubule

5. Study Questions
1. Which of the following Diuretics is the first line used
to Glaucoma?
a. Lasix®
b. Aldactone ®
c. Diuril®
d. Diamox®

6. 2. Which of the following Diuretics is the first line used
to Hypertension with Hyperkalemia ?
a. Lasix®
b. Osmitrol®
c. Aldactone®
d. Diamox®

7. 3. Which of the following Diuretics is the first line used
in cases of Hyperaldosteronism ?
a. Lasix®
b. Aldactone ®
c. Diuril®
d. Diamox®

8. 4. Which of the following Diuretics is the first line used
to Hypertention?
a. Lasix®
b. Aldactone®
c. Diuril®
d. Diamox®

9. 5. Which of the following Diuretics is the first line used
in cases of edema ?
a. Lasix®
b. Aldactone®
c. Diuril®
d. Diamox®

10. 6. Which of the following Diuretics is the Second line
used to Hypertension?
a. Lasix®
b. Aldactone®
c. Diuril®
d. Diamox®

11. 2. Complete the following Table with an appropriate
diuretics below
-Loop Diuretic
-Osmotic Diuretics
-Potassium Sparing diuretics
-Thiazides
-Carbonic Anhydrase Inhibitors
Diuretic
Site of Action
Loop of Henle
Distal Convoluted Tubule
Collecting Tubule
Proximal Convoluted tubule
Entire Tubule
Abdulqadir Nashwan