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9.epirazole
- 1. Epirazole®
- 2. Epirazole® Composition Each Capsule Contains: Enteric coated pellets of Omeprazole ….…. 20 mg Packaging: 14 Caps ..in a Jar
- 3. WHY ENTERIC COATED PELLETS? • EC pellet forms provide rapid onset of action and faster drug release due to the smaller size • omeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+-ATPase (the acid pump) and inhibits both basal and stimulated acid secretion. • omeprazole is acid-activated for such types of drugs enteric coating added to the formulation tends to avoid activation in the mouth and esophagus. • delayed-release forms of omeprazole, the waiting before eating after taking the medication is not necessary
- 5. EC PELLETS DRUG DELIVERY TECHOLOGY
- 6. Epirazole® Mechanism of action • Epirazole ® belongs to Proton Pump inhibitors class • Epirazole ® inhibits the H+/K+ ATPase pump blocking the very last step of gastric acid secretion
- 8. Epirazole® Indications GERD Peptic Ulcers Dyspepsia Zollinger Ellison’s Disease Heartburn associated with NSAIDs H.Pylori
- 9. 1. GERD Signs& Symptoms Heartburn and acid regurgitation are the most common complaints. chest pain, laryngitis, coughing, and wheezing, and Dyspepsia(acid indigestion) GERD dosage regimen 20 mg EPIRAZOLE taken once a day for 4 weeks . Epirazole® Patient Profile
- 10. Epirazole® Patient Profile 2-Dyspepsia Feeling of fullness during a meal, uncomfortable fullness after a meal, and burning or pain in the upper abdomen . caused by : (GERD), peptic ulcer disease, or cancer. Dosage regimen: 10-20 mg 2-4 weeks
- 11. Epirazole® Patient Profile 3- peptic ulcer (Duodenal ulcer or benign gastric ulcer or NSAID- associated peptic ulcers) Dosage regimen 20mg once 4-8 weeks *Prevention of recurrence (people at risk) 10 mg once and may be increased to 20mg *severe or recurrent cases the dose may be increased to 40mg
- 12. 4- Zollinger Ellison’s Disease Endocrinopathy characterized by gastrin-secreting tumors, responsible for causing the formation of multiple, refractory, and recurrent peptic ulcers in the distal duodenum and proximal jejunum. Dosage Regimen 60 mg EPIRAZOLE once daily. The dosage should be adjusted individually and treatment continued as long as clinically indicated Epirazole® Patient Profile
- 13. Epirazole® Patient Profile 5- Prophylaxis of NSAID-associated gastric ulcers, duodenal ulcers, gastro duodenal erosions and dyspeptic symptoms. Dosage Regimen 20 mg EPIRAZOLE taken once daily.
- 14. Epirazole® Safety 1- Epirazole Safe for long term treatment No treatment related mucosal changes have been observed in patients treated continuously with Omeprazole for up to 5 years. 2- Epirazole Safe use with NSAIDs There is no evidence of an interaction with piroxicam, diclofenac or naproxen. 5
- 15. Epirazole® Dosage regimen Indication Dosage Duration GERD 20mg once daily 4-8 weeks DYSPEPSIA 20mg once daily 2-4 weeks PEPTIC ULCER 20mg once daily 4-8 weeks Treatment of EE due to Acid- Mediated GERD 20 mg once daily 4 to 8 weeks Maintenance of Healing of EE due to Acid-Mediated GERD 20 mg once daily Controlled studies do not extend beyond 12 months.
- 16. Epirazole® Dosage regimen Indication Dosage Duration NSAIDs 20mg once daily For prophylaxis ZOLLINGER ELLISON 60 mg once daily adjust to patient needs Dosages up to 120 mg three times daily have been administered.
- 17. Thank you