3. CV TOXICITY
INVESTIGATIONS
Investigation
Laboratory ECG
S. drug level Glucose S.K+ KFTs ABG
4. TOXICITY TREATMENT
GENERAL GUIDELINES
Treatment
Stabilization Decontamination Elimination Antidote Supportive
MDAC: dig., Bradycardia,
GL theo Very high level AVB
Ventricular
AC Dialysis: theo Serious C/P dysrhythmias
Huge dose Hyperkalemia
5. TREATMENT OF SERIOUS
DYSRHYTHMIAS
TdP V-tach
MgSO4 IV Cardioversion
Overdrive pacing NaHCO3 IV
Cardioversion Lignocaine
Phenytoin Phenytoin
Esmolol
13. DIGOXIN TOXICITY
INVESTIGATIONS
ECG changes
• Due to digoxin intake
• Due to digoxin toxicity
• Due to potassium
disturbances
• Due to pre-existing cardiac
condition
23. CALCIUM CHANNEL
BLOCKERS
They block slow Ca channels of vascular smooth muscles and
cardiac muscles.
Acute toxicity is similar to B-blockers
Treatment is as in B-blockers. In addition, CaCl2 10% 10ml IV
over 10 min for hypotension and myocardial depression.