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Diabetes mellitus type 2
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Chronic hyperglycemia
Glucotoxicity 2 Lipotoxicity 3 Oversecretion of insulin to compensate for insulin resistance 1,2 -cell dysfunction
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IR Insulin resistance
Liver Muscle Adipose tissue Glucose output Glucose uptake Glucose uptake Hyperglycemia
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Carbohydrate Glucose(G)-I (I)-Insulin
Carbohydrate Acarbose Reduces absorption Sulphonylurea Repaglinide Stimulates pancreas Metformin Reduces hepatic glucose output (??muscle/fat effects) Thiazolidinediones Reduce Insulin Resistance
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