Contenu connexe Plus de Татьяна Древицкая (10) Taste sensitivity6. Polycystic kidney
disease 2-like 1
protein
also known as
Transient receptor
potential polycystic
3 (TRPP3) –
cation-selective ion
channels that are
permeable to calcium
PKD2L1
7. Taste receptors
• TAS1R (3 types): sweet and umami (ligands – sugars and glutamate)
• TAS2R (50 types): bitter (ligands – alkaloids and polyphenols)
• PKD2L1: sour (H+ activated Ca2+ channel)
• ENaC: salty ( Na+ channel)
• GPR40, GPR120, GPR119: fatty acids
• mGluR1 and mGluR4: umami (glutamate)
16. Extracellular recording system to trap adenosine triphosphate (ATP)
released from a taste bud cell of α-gustducin–green fluorescence
protein (Gust-GFP) mice
Murata Y et al. J Neurophysiol 2010;104:896-901
©2010 by American Physiological Society
18. UMAMI RECEPTOR ACTIVATION INCREASES
DUODENAL BICARBONATE SECRETION …
Wang JH, Inoue T, Higashiyama M, Guth PH, Engel E, Kaunitz JD, Akiba Y.
J Pharmacol Exp Ther. 2011 Nov;339(2):464-73.