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Taste sensitivity
Senior researcher,
Bogomoletz Institute of Physiology,
Dr. Tetiana Drevytska
Reception vsperception
1. sweet
2. salty
3. sour
4. bitter
5. umami or savory
Polycystic kidney
disease 2-like 1
protein
also known as
Transient receptor
potential polycystic
3 (TRPP3) –
cation-selective ion
channels that are
permeable to calcium
PKD2L1
Taste receptors
• TAS1R (3 types): sweet and umami (ligands – sugars and glutamate)
• TAS2R (50 types): bitter (ligands – alkaloids and polyphenols)
• PKD2L1: sour (H+ activated Ca2+ channel)
• ENaC: salty ( Na+ channel)
• GPR40, GPR120, GPR119: fatty acids
• mGluR1 and mGluR4: umami (glutamate)
Extracellular recording system to trap adenosine triphosphate (ATP)
released from a taste bud cell of α-gustducin–green fluorescence
protein (Gust-GFP) mice
Murata Y et al. J Neurophysiol 2010;104:896-901
©2010 by American Physiological Society
UMAMI RECEPTOR ACTIVATION INCREASES
DUODENAL BICARBONATE SECRETION …
Wang JH, Inoue T, Higashiyama M, Guth PH, Engel E, Kaunitz JD, Akiba Y.
J Pharmacol Exp Ther. 2011 Nov;339(2):464-73.
Taste sensitivity
Taste sensitivity
Taste sensitivity
Taste sensitivity

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Taste sensitivity

  • 1. Taste sensitivity Senior researcher, Bogomoletz Institute of Physiology, Dr. Tetiana Drevytska
  • 2. Reception vsperception 1. sweet 2. salty 3. sour 4. bitter 5. umami or savory
  • 3.
  • 4.
  • 5.
  • 6. Polycystic kidney disease 2-like 1 protein also known as Transient receptor potential polycystic 3 (TRPP3) – cation-selective ion channels that are permeable to calcium PKD2L1
  • 7. Taste receptors • TAS1R (3 types): sweet and umami (ligands – sugars and glutamate) • TAS2R (50 types): bitter (ligands – alkaloids and polyphenols) • PKD2L1: sour (H+ activated Ca2+ channel) • ENaC: salty ( Na+ channel) • GPR40, GPR120, GPR119: fatty acids • mGluR1 and mGluR4: umami (glutamate)
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16. Extracellular recording system to trap adenosine triphosphate (ATP) released from a taste bud cell of α-gustducin–green fluorescence protein (Gust-GFP) mice Murata Y et al. J Neurophysiol 2010;104:896-901 ©2010 by American Physiological Society
  • 17.
  • 18. UMAMI RECEPTOR ACTIVATION INCREASES DUODENAL BICARBONATE SECRETION … Wang JH, Inoue T, Higashiyama M, Guth PH, Engel E, Kaunitz JD, Akiba Y. J Pharmacol Exp Ther. 2011 Nov;339(2):464-73.