Science Week 2013 Activity Centre Cultural de Martorell Integrated Plan for Foreign Languages Institut Pompeu Fabra

1. How do drugs work?
Dr. Francisco Pérez García
Departament de Farmacologia

2. Donat el caràcter i la finalitat exclusivament docent i eminentment
il·lustrativa de les explicacions a classe d'aquesta presentació,
l’autor s’acull a l’article 32 de la Llei de Propietat Intel·lectual vigent
respecte de l'ús parcial d'obres alienes com ara imatges, gràfics o
altre material contingudes en les diferents diapositives

4. The term pharmacology comes from the Greek words:
•pharmakon - drug or medicine
•logos - the truth about or a rational discussion

5. A synthesis of several biomedical sciences….
Pharmacology
…but unique in its own right

6. Pharmacologists Study Science at Every Level

7. (2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)- 3-(benzoylamino)2-hydroxy-3-phenylpropanoyl]oxy}- 1,7-dihydroxy-9-oxo-5,20-epoxytax11-en-2-yl benzoate = TAXOL
A LITTLE BIT OF CHEMISTRY AND A LITTLE BIT OF BOTANY

8. FROM AMINOACIDS TO PROTEIN DRUG RECEPTORS

28. RELATIONSHIP BETWEEN PROTEIN STRUCTURE AND FUNCTION
Function relies on interactions with other molecules
Binding of molecules to proteins is reversible
LOCK AND KEY THEORY
Ligand = molecule bound reversibly by a protein
Binding site = site on protein where ligand binds
HIV protease + drug inhibitor

29. Kd = Kon/Koff = [D][R]/[DR]
Ka = 1/Kd = Koff/Kon =
[DR]/[D][R]

32. Induced fit model vs lock and key model

52. ACKNOWLEGMENTS
The project «Contemporary Sciences and Research» (2012-2014)
belongs to the Integrated Plan for Foreign Languages of Departament
Of Education, Government of Catalonia
More info at www.formaciovirtual.com/cs
and www.tecnologies.net
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