Barrett’s esophagus

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drimranmujawar

barrets esophagus

Santé & Médecine

Mucosal Pathology of Gastric
Cardia and Barrett’s oesophagus

Oesophageal biopsy origin
• Oesophageal submucosal glands
or ducts,
• Native squamous epithelium
• Multilayered epithelium

Grading dysplasia in Barrett’s
esophagus algorithm
• Surface maturation compared to
underlying glands
• Architecture of the glands
• Cytologic features
• Inflammation and erosions/ulcers

BIOMARKERS FOR RISK
STRATIFICATION
• PLOIDY
• TP53
• Aberrant tumour suppressor gene promoter
methylation

Follow up of Barrett’s esophagus
Dysplasia grade Documentation Followup
None Two EGDs with
biopsy
3yr
Low grade Highest grade on
repeat
1yr until no
dysplasia
High grade Repeat endoscopy
to exclude cancer
,expert confirmation
Every 3 month

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