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Citric acid cycle
1.
2.
Citric Acid Cycle
3.
Gylcolysis Electron Transport and Oxidative
phosphorylation TCA Cycle
4.
5.
Entry into the
TCA Cycle
6.
7.
8.
Only step in
TCA cycle that involves the formation of a C-C bond
9.
10.
11.
12.
13.
Isocitrate Dehydrogenase
14.
15.
-Ketoglutarate Dehydrogenase
16.
17.
Succinyl-CoA Synthetase
18.
19.
20.
Fumarase
21.
22.
Malate Dehydrogenase
23.
24.
Acetyl-CoA + 3
NAD+ + Q + GDP + Pi +2 H20 HSCoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+ Isocitrate Dehydrogenase 1 NADH=2.5 ATP a-ketoglutarate dehydrogenase ATP 1 NADH=2.5 Succinyl-CoA synthetase 1 GTP=1 ATP Sunccinate dehydrogenase Malate Dehydrogenase ATP Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA 1 QH2=1.5 ATP 1 NADH=2.5
25.
26.
Regulation of TCA Cycle
27.
28.
29.
Protein/amino acid Catabolites feed Into
the TCA Cycle
30.
Fats breakdown and
feed into the TCA Cycle
31.
TCA Cycle provides
intermediates for many biosynthetic processes
32.
The "filling up"
reactions • PEP carboxylase - converts PEP to oxaloacetate • Pyruvate carboxylase - converts pyruvate to oxaloacetate • Malic enzyme converts pyruvate into malate
33.
34.
Following the carbons through
the TCA cycle