4. LAYERED DEFENSE Components of the immune system Found only in jawed vertebrates Found in nearly all forms of life Exposure leads to immunological memory No immunological memory Cell-mediated and humoral components Cell-mediated and humoral components Lag time between exposure and maximal response Exposure leads to immediate maximal response Pathogen and antigen specific response Response is non-specific Adaptive immune system Innate immune system
23. Allergy Autoimmunity Rejection of organ transplant An immune cell undergoing an allergic reaction Protects against infectious agents
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28. Themectomy TT given 1. Thymosin fraction V (Calf thymus) 2. Synthetic polypeptides Thymus
29. Ontogeny of Immune System Fetus T cells Functions at 7- 1/2 wks Thymus functions at 12 wks B cells Functions at 13 wks IgM First to develop. Rises in intrauterine infection Reaches adult levels by 1 yr IgG Develops at 4 years IgA At adolescence
46. AIDS Acquired immunodeficiency syndrome Pathophysiology Clinical diagnosis Treatment Prevention HIV, the virus that causes AIDS, is shown budding out of a human immune cell.
47. HIV Treating HIV infected woman during pregnancy Natural history of HIV infection Transmission Signs and symptoms of AIDS in new born How does pediatric AIDS differ from adult AIDS Management & Specific retroviral therapies AZT (3’ Azido, 2’ 3’ deoxythymdine) DDI (2’ 3’ Dideoxyinosine) Immunotherapy (Hyposensitization)