Medicine 5th year, 5th lecture/part two (Dr. Abdulla Sharief)
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The lecture has been given on May 12th, 2011 by Dr. Abdulla Sharief.
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Medicine 5th year, 5th lecture/part two (Dr. Abdulla Sharief)
- 1. Myelodysplastic syndromes Achievements in understanding and treatment
- 7. Known molecular abnormalities in MDS 5-10 Point mutation (codon 969 or rarely 301) FMS (encodes M-CSF receptor) 5 Point mutation or deletion of other allele P53 10-30% Point mutation (codon 12, 13 or 61) RAS (N or K) Incidence (%) Type of anomaly Gene
- 10. Myelodysplastic features in MDS Bone marrow: multinuclearity, nuclear fragments, megaloblastoid changes, cytoplasmic abnormalities, ringed sideroblasts Peripheral blood: Poikilocytosis, anisocytosis, nucleated red blood cells Dyserythropoiesis Bone marrow and/or peripheral blood findings MDS
- 11. Myelodysplastic features in MDS Micromegakariocytes Large mononucle a r forms Multiple small nuclei Dysmegakariopoiesis Nuclear abnormalities including: hypolobulation, ring-shaped nuclei, hypogranulation Dysgranulopoiesis Bone marrow and/or peripheral blood findings MDS