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Myeloproliferative Disorders
Overview ,[object Object],[object Object],[object Object],[object Object],[object Object]
Polycythemia ,[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Polycythemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Polycythemia vera ,[object Object],[object Object],[object Object]
P vera - natural history ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Erythromelalgia
P vera – signs: ,[object Object],[object Object],[object Object],[object Object]
P vera - Lab Findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WHO criteria ,[object Object],[object Object],[object Object],[object Object],[object Object]
WHO criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - phlebotomy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - Myelosuppression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - interferon alpha ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Essential Thrombocythemia ,[object Object],[object Object],[object Object],[object Object]
ET - Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - natural history ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - Labs ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - Abnormal Megakaryocytes Arrows indicate some of the abnormal mega-karyocytes
ET - Treatment ,[object Object],[object Object],[object Object],[object Object]
ET - therapeutic agents ,[object Object],[object Object],[object Object]
ET - anagrelide ,[object Object],[object Object]
Myelofibrosis ,[object Object],[object Object],[object Object]
MF - Natural Hx and Sx ,[object Object],[object Object],[object Object],[object Object],[object Object]
MF - Physical Findings ,[object Object],[object Object]
MF - Lab findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tefferi A. N Engl J Med 2000;342:1255-1265 Pathological Features of Peripheral Blood and Bone Marrow in Patients with Myelofibrosis with Myeloid Metaplasia
MF - Treatment ,[object Object],[object Object],[object Object],[object Object]

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Medicine 5th year, 9th lecture/part one (Dr. Sabir)

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  • 27. ET - Abnormal Megakaryocytes Arrows indicate some of the abnormal mega-karyocytes
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  • 35. Tefferi A. N Engl J Med 2000;342:1255-1265 Pathological Features of Peripheral Blood and Bone Marrow in Patients with Myelofibrosis with Myeloid Metaplasia
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Notes de l'éditeur

  1. Figure 3. Pathological Features of Peripheral Blood and Bone Marrow in Patients with Myelofibrosis with Myeloid Metaplasia. Panel A shows myelophthisis of the blood. Immature granulocyte precursors, a nucleated red cell, and teardrop-shaped red cells are visible (Wright-Giemsa, x200). Biopsy specimens of the bone marrow core show stromal stranding and atypical megakaryocytes (Panel B; hematoxylin and eosin, x128), collagen fibrosis on silver-impregnation staining of reticulin (Panel C, x128), and thickening of the bone trabeculae (osteosclerosis) and intramedullary sinusoidal hematopoiesis (Panel D; hematoxylin and eosin, x128).