This document summarizes key aspects of bone tissue. It describes the components of bone matrix, which consists of cells, fibers, and extracellular matrix made of type 1 collagen. Bone matrix also contains minerals like hydroxyapatite crystals that provide hardness, strength and durability. The document outlines the main cell types involved in bone formation and remodeling, including osteoprogenitor cells, osteoblasts, osteocytes and osteoclasts. It explains the two processes of bone formation: endochondral ossification and intramembranous ossification. Finally, it distinguishes between the two types of bone tissue: compact bone and spongy bone.
2. BONE TISSUE
Bone Matrix: consists of cells, fibers and
ECM made up of type 1 collagen
Highly vascular
+ Mineral deposition: Bone → Calcified
Bear more wt
Withstand stress
Provide attachment sites for muscles
and organs
Hematopoiesis
Storage of Ca+2 and phosphate
3. BONE MATRIX
Bone Matrix: consists of cells, fibers and
ECM made up of type 1 collagen
Organic components: sulfated
glycosalmiglycans and hyaluronic acid
→ larger proteoglycan aggregrates
Mineralization: Glycoproteins osteocalcin and
osteopontin bind to calcium
Sialoprotein binds osteoblasts to ecm through
integrins of plasma membrane
Inorganic components:
Calcium + phosphate = hydroxyapatite crystals +
collagen fibers = bone hardness durability strength
4. BONE CELLS
Osteoprogenitor cells:
undifferentiated, pleuropotential stem
cells
Osteoblasts: @ surface of the bone
that synthesize, secrete bony matrix;
active
Osteocytes: mature form of
osteoblasts; maintain the structural
integrity of the matrix
Osteoclasts: resorb bone during
11. Spongy Bone
Also called cancellous or trabecular
bone
No formal osteons
Trabeculae
Forms most of the structure of short,
flat, and irregular bones, and the
epiphyses of long bones.
12. Spongy bone (Trabeculae)
Latticework of thin plates of bone
oriented along lines of stress
Contains red bone marrow
(hemopoiesis)
Found in ends of long bones and
inside flat bones such as the
hipbones, sternum, sides of skull, and
ribs.
21. Compact Bone
• The structural unit of compact bone is the
osteon or Haversian system.
• Each osteon is an elongated cylinder
running parallel to the long axis of the
bone.
• It actually contains canals and
passageways that provide access for
nerves, blood vessels, and lymphatic
ducts.
• Each columns is made up of concentric
rings or lamellae along the calcified matrix.
22. Concentric layers or
rings along the calcified
matrix.
Tiny cavities inside the
lamellae. This is the
space where the
osteocyte are found.
It is the central canal that
is surrounded by
concentric lamellae.
Tiny hair-like channels
that are branching.
Compact Bone
23.
24. • Connects two
Haversian
canals.
• Canals lie at
right angles to
long axis of
bone.
• Connect the
vascular supply
of the
periosteum to
those of the
central canal and
medullary cavity.
Volkmann’s canal
Main constituent of skeleton
Bone matrix: contains organic and inorganic components where organic enable bones to resist tension and the mineral components enable bones to resist compression
Osteoprogenitor cells: located on the inner layer of periosteum and in the single layer of endosteum that lines the marrow cavities, harvesian system, and perforating canals.
Perio and endo fxn: nutrition of bone and provide continous supply of new osteoblasts for growth remodeling and repair of bones
During bone dev’t osp cells proliferate by mitosis and differentiate into osteoblasts than secretes the bony matrix
Osteocytes: smaller than osteoblasts; trapped by the surrounding bone matrix produced by osteoblasts; one osteocyte in each lacuna; principal cells of the bone
Osteoclasts: large multinucleated cells where removal and remodeling and repair of bone take place; located on howship’s lacunae
Calcified Matrix- serves as structural framework for deposition of bony material
Endosteum- lines internal cavities n bone; single layer of osteoprogenitor cells
Osteoid Matrix- produced by osteoblasts mineralized into bone
Epiphyseal Plate Region- growth continues and responsible for lenghtening bone until bone growth stops. Excepet in the free ends of long bones where a layer of permanent hyaline cartilage covers bone called articular cartilage
forms the mandible, clavicles, and flat bones of the body
bone development not preceded by a hyaline cartilage model, instead bone develops from condensation of CT mesenchyme to form an ossification center
mesenchyme cells differentiate directly into osteoblasts that produce the bone matrix, called osteoid
the bone matrix becomes calcified, osteoblasts become osteocytes within lacunae, and the process repeats resulting in production of layers of bone