This lecture was the opening lecture on the ‘Physiology of Coagulation’ at the Continuing Medical Education (CME) Grand Rounds, 2011. Organised by Kuwait Anesthesia Council, Kuwait
Call Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service Available
Physiology of Coagulation
1.
2. Introduction
Coagulation is a complex process by which blood
forms clots.
An important part of hemostasis.
The process is described in 2 steps:
PRIMARY
SECONDARY
11. Cell Based Model of Coagulation
D. Monroe M. Hoffman
Proposal
The cascade is a biochemical model.
NOT a true reflection of what happens in the body.
13. Cell Based Model of Coagulation
Initiation
[TF Cell]
Amplification
[Platelet]
Propagation
[Active Platelet]
Stabilization
of Clot
Inhibition of
Further
Coagulation
Five Steps
Two Cells
20. Inhibitors of Coagulation
• Inhibition of the TF-VIIa complex.
• Binds to directly inactivate
thrombin as well as the factors
(IXa, Xa, and XIa).
• Catalyses:Plasminogen Plasmin
21. Inhibitors of Coagulation
• Protein C is activated when thrombin
binds to thrombomudulin.
• Protein S boosts the activity of Protein C.
• Jointly, they inactivate Factor Va &
VIIIa.
• Plasmin degrades fibrin strands. Prevents
build-up of excess clot.
Fibrinolytic
System