.

1. Granulomatous diseaseTuberculosis & Sarcoidosis

2. Tuberculosis
• A complication of pulmonary disease with
infected sputum.
• Orally: lump or chronic ulcer on the tongue

3. Etiology and
Pathogenesis
• Typical:
Mycobacterium tuberculosis
• Atypical:
M avium-intarcelluler
M scrofulaceum

4. Diagnosis
• Ziehl-Neelsen stain
• Immunofluorescence using
Auramine Rhodamine
• Macubacterium culture
• Macrobacterium DNA
• Tubercalien skin test

5. Clinical changes
• Cervical Mycobacterial Lymphadenitis
unilateral
single or multiple
asymptomatic

6. Histopathology

7. Casation Necrosis

8. Sarcoidosis
• Chronic disease with a unknown
cause, in which granuloma forms in
1- lungs
2- lymph
3- slivery gland
4- mouth
• Heerfordt’s syndrome

9. Clinical changes
• Multisystem granulomatosis disorder
• Cause:
Propiono Bacterium acnes
Propiono Granulosum
Mycobacterium tuberculosis

10. Ddiagnosis
• Minor salivary gland biopsy “granuloma in 20%”
• Chest radiograph
• Gallium scan
• Raised SACE
• Raised adenosine deaminase “ADA test”

11. Histopathology

12. Asteroid bodies Schaumann bodies

13. Sarcoidosis
of a Salivary
gland