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R&D PIPELINE REVIEW
TERRY CREWS
CFO
STEVE PADGETTE, PH.D.
VICE PRESIDENT, BIOTECHNOLOGY


January 8-9, 2008



                                1
Forward-Looking Statements

Certain statements contained in this presentation are quot;forward-looking statements,quot; such as statements
concerning the company's anticipated financial results, current and future product performance,
regulatory approvals, business and financial plans and other non-historical facts. These statements are
based on current expectations and currently available information. However, since these statements are
based on factors that involve risks and uncertainties, the company's actual performance and results may
differ materially from those described or implied by such forward-looking statements. Factors that could
cause or contribute to such differences include, among others: continued competition in seeds, traits and
agricultural chemicals; the company's exposure to various contingencies, including those related to
intellectual property protection, regulatory compliance and the speed with which approvals are received,
and public acceptance of biotechnology products; the success of the company's research and
development activities; the outcomes of major lawsuits, including proceedings related to Solutia Inc.;
developments related to foreign currencies and economies; successful operation of recent acquisitions;
fluctuations in commodity prices; compliance with regulations affecting our manufacturing; the accuracy
of the company's estimates related to distribution inventory levels; the company's ability to fund its short-
term financing needs and to obtain payment for the products that it sells; the effect of weather conditions,
natural disasters and accidents on the agriculture business or the company's facilities; and other risks
and factors detailed in the company's most recent periodic report to the SEC. Undue reliance should not
be placed on these forward-looking statements, which are current only as of the date of this presentation.
The company disclaims any current intention or obligation to update any forward-looking statements or
any of the factors that may affect actual results.

Trademarks
Trademarks owned by Monsanto Company and its wholly-owned subsidiaries are italicized in this
presentation. All other trademarks are the property of their respective owners.


© 2008 Monsanto Company




                                                                                                                2
Non-GAAP Financial Information

This presentation may use the non-GAAP financial measures of “free cash flow,” earnings per share (EPS) on an
ongoing basis and Return on Capital (ROC). We define free cash flow as the total of cash flows from operating
activities and investing activities. A non-GAAP EPS financial measure, which we refer to as ongoing EPS, excludes
certain after-tax items that we do not consider part of ongoing operations, which are identified in the reconciliation.
ROC means net income (without the effect of certain items) exclusive of after-tax interest expenses, divided by the
average of the beginning year and ending year net capital employed, as defined in the reconciliation. Our
presentation of non-GAAP financial measures is intended to supplement investors’ understanding of our operating
performance, not replace net income (loss), cash flows, financial position, or comprehensive income (loss), as
determined in accordance with GAAP. Furthermore, these non-GAAP financial measures may not be comparable to
similar measures used by other companies. The non-GAAP financial measures used in this presentation are
reconciled to the most directly comparable financial measures calculated and presented in accordance with GAAP.
Monsanto is unable to provide a reconciliation of the 2008 ROC goal to projected net income and financial position
for 2008 without unreasonable effort. As shown in the ROC reconciliation for the previous year, the calculation of
ROC is complex, and Monsanto does not have sufficient information at this point in the fiscal year to reasonably
estimate its operating profit after-tax and average capital for 2008 due to market and other conditions that are
outside of Monsanto’s control.
With respect to the time period prior to Sept. 1, 2000, references to Monsanto in this presentation also refer to the
agricultural business of Pharmacia.


FISCAL YEAR:
References to year, or to fiscal year, are on a fiscal year basis and refer to the 12-month period ending August 31.




                                                                                                                          3
FINANCIAL REVIEW


2008 Again Projects Double-Digit Earnings Growth,
Strong Cash Generation and Improved Margins

                                                           2007                2008F
   EARNINGS
                                                            $2.00          $2.50-$2.60
       ONGOING EARNINGS PER SHARE                       54% GROWTH      25-30% GROWTH
                                                         FROM 2006         FROM 2007
                                                                         Further progress on
                   Gross Profit as a Percent of Sales      50%        trajectory toward 52-54%
                                                                             2010 target
                         Seeds & Traits Gross Profit       $3.0B               ~$3.5B
         Roundup And All Other Glyphosate-based
                                                           $854M          Greater than $1B
                          Herbicides Gross Profit
             All Other Ag Productivity Gross Profit        $418M              ~$350M
   CASH MANAGEMENT AND SPENDING
                            FREE CASH FLOW                $(57)M            $900M-$1B
                                   Return on Capital       14.8%     Consistent with 2007 levels
                               Capital Expenditures        $509M        Greater than $800M
                         SG&A as a Percent of Sales        22%             20-21% Range
                          R&D as a Percent of Sales         9%              10% Range
                   Receivables as a Percent of Sales       18%       Consistent with 2007 levels
                   Inventories as a Percent of Sales       20%       Consistent with 2007 levels


                                                                                                   4
OVERVIEW


   Given Growth Opportunities, Monsanto Has Potential to More
   Than Double Gross Profit Over Next Five Years

                                                                                        2012 GROWTH RANGE
                                       MONSANTO GROSS PROFIT
                                          GROWTH TARGET                             Gross profit targeted to double
                                                                                    from 2007 through 2012
                 $9,000
                                                                                       STRATEGIC PLAYBOOK
                 $8,000
                                                                                    All growth is organic, from
                 $7,000
                                                                                    base business and pipeline
GROSS PROFIT
 (IN MILLIONS)




                 $6,000                                                                 U.S. Corn
                                                                                        International Corn
                 $5,000
                                                                                        Soybeans
                                                                                        Cotton
                 $4,000
                                                                                        Seminis
                 $3,000                                                                 R&D Pipeline
                                                                                    Acquisitions to be pursued,
                 $2,000
                                                                                    but are not included in this
                 $1,000                                                             growth projection
                                                                                    Earnings continue to translate
                    $0
                                                                                    into operating cash, and value
                          MILESTONES




                                       2004                 2007            2012
                                                                                    created for shareowners
                                                                   2010
                                                  2007
                                                                                    through combination of
                                                                   Gross margin
                                       Base Gross Profit:
                                                                                    acquisitions, share
                                                                   target: 52-54%
                                                $4,286M
                                                                                    repurchases and dividends
                                                            ONGOING EPS GROWTH:
                                                            MID-TO-HIGH TEENS

                                                                                                                      5
OVERVIEW

Our Biotech and Breeding Pipeline Is Accelerating, With
Progress in Projects and Widening Yield Advantages

                                                                     MILESTONES:
                                                          Biotech pipeline is accelerating
                                                           10 projects either advanced phases or
                                                           were added to the pipeline – among the
                                                           most in any annual update
                     Q1      Q4                            First time transitioned 4 projects from
                                                           Phase 2 to Phase 3
                     Q2      Q3                            First multi-generational advancement as 2
                                                           generations of corn drought family
                                                           advance
                                                           SmartStax enters the pipeline as the
                                                           platform for corn, complementing
                                                           Roundup RReady2Yield as the soybean
                                                           platform
    ANNUAL R&D CYCLE: SEEDS & TRAITS
                                                          Breeding programs yields impressive
WHAT CHANGED 2007-2008?
                                                           DEKALB germplasm maintains impressive
• 5 projects advanced phases                               8.4 bu/ac advantage; gap widens to 14.6
• 5 products added                                         bu/ac when protected with YieldGard VT
• Vistive II removed in favor of Vistive III               Triple stack
• “Water-use efficiency” soybeans reclassified as
                                                           Asgrow germplasm yield advantage
  “2nd-Gen Higher-Yielding soybeans”
                                                           improves to average 1.27 bu/ac; Roundup
• Two former Renessen projects rolled into the Monsanto
                                                           RReady2Yield to provide 7-11% boost
  pipeline

                                                                                                       6
OVERVIEW


Pipeline Leverages Power of Breeding and Biotech for Current
Commercial Growth and New Platforms in Next Decade
                                                 MONSANTO’S R&D PIPELINE
                               DISCOVERY             PHASE I            PHASE II
                  R&D PHASE:                                                              PHASE III        PHASE IV       LAUNCH




                                                              BREEDING


            G

                                                                                                           COMMERCIAL
                                                                          IT PLATFORM
                                                            GERMPLASM




                                                                                                          INTEGRATION
                                                                                            ANALYTICS



                                                                                                          COMMERCIAL
                                                  MARKERS
                                      GENOMICS                                                                            SEED




                                                              ELITE
             Germplasm




                                                                                                             TRAIT
                                                                                                                          SOLD TO
                         R                                                                                                FARMERS



                                                     BIOTECHNOLOGY

                                                                                                        Pipeline Priorities Through 2012
            Pipeline Priorities Through 2012
                                                                                        BIOTECHNOLOGY
 BREEDING
                                                                                           Deliver the Value in Monsanto’s Established
   Continue to Drive Breeding Gains Across Crop
                                                                                           Trait Pipeline
   Platforms
                                                                                           Unlock the Opportunity in Yield and Stress
 ► Ensure momentum in corn breeding continues
                                                                                           Through the BASF Collaboration
 ► Accelerate ramp up of soybean breeding
 ► Continue application of proven tools to cotton and                                   ► Deliver the industry’s first traits in the emerging yield-
   vegetables                                                                             and-stress arena
                                                                                        ► Change the trait-value opportunity with “product
                                                                                          families”

                                                                                                                                                       7
CORN BREEDING

   Final Yield Trial Results Reinforce Yield Advantage of
   DEKALB Seed in U.S.

                                                                             2007 FINAL U.S. COMPETITIVE CORN YIELD
                                                          FINAL:
                                                                             COMPARISON: DEKALB
                                                                                  DEKALB
                     U.S.
GEOGRAPHY:                                                            210




                                          (APPROXIMATE DIFFERENCES)
                                                                                  COMPETITORS
                     Grow footprint                                   205
OBJECTIVE:

                                                                                                                205
2007 PERFORMANCE UPDATE                                               200
                                                BUSHELS/ACRE
• In > 14,000 comparisons,                                            195
                                                                                                                                        197
  Monsanto out-yields                                                                                                       195
                                                                      190                                             193
  competitive best by                                                                               191
                                                                                        190                                       189
                                                                      185                                                                     188
  8.4 bu/ac                                                                                               186
                                                                      180
• In 110-day RM,
  Monsanto’s lead remains                                                                     179
                                                                      175
  a strong 12 bu/ac
                                                                      170
  advantage
                                                                      165
Source: 2007 Monsanto
                                                                      160
and third party trials
                                                                            163
through November 15,
                                                                      155
2007. Weighted
                                                                                  155
average, calculated to
                                                                      150
15% moisture. DEKALB
products are compared
                                                                            95 RM       100 RM      105 RM      110 RM      115 RM      Overall
with national competitive   RELATIVE MATURITIES (DAYS)►
products that contain
                                                                            >480        >1,220      >1,820      >5,220      >5,270      >14,000
                                      COMPARISONS:
similar crop protection
traits.
                                APPROXIMATE BU/AC
                                                                             7.8         10.4        5.1         12.0        5.5          8.4
                                      ADVANTAGE:


                                                                                                                                                    8
CORN BREEDING


Again in 2007, Best in Class Germplasm and Trait Integration
Delivers Best Yield

                              TOTAL DEKALB SEED & TRAIT YIELD PERFORMANCE IN 2007
  FINAL


                                 Seed & Trait: Head-to-Head
AVE. BUSHELS PER ACRE




                        210
                                                   14.6
                                     211.6
                        206
                                                    BU/AC
                        202                        ADVANTAGE
                        198
                                                               197.0
                        194
                        190
                                   MONSANTO                 Pioneer ®
                                                       Competitive Hybrids
                               DEKALB Hybrids
                                                                             Performance in Key Corn Belt States
                                                         with Herculex®
                               with YieldGard VT
                                                       XTRA and Roundup
                                     Triple
                                                                                             NE       IA            IL
                                                          Ready Corn 2

                                                                                             >70     >400          800
                        Nearly 1,700 comparisons in 17 states: DEKALB        Comparisons:
                            seed, protected by YieldGard VT Triple,
                                                                                             210      214          219
                                                                                 Monsanto
                         outperformed the best competitive seed-and-              Brands:    bu/ac    bu/ac        bu/ac
                           trait package by >14.6 bu/ac on average
                                                                                             193      200          202
                                                                               Competitive
                                                                                  Brand:     bu/ac    bu/ac        bu/ac


                                                                                                                           9
SOYBEAN BREEDING


Roundup RReady2Yield and Molecular Breeding Rewrite
Historic Soybean Yield Trends

                                        SOYBEAN YIELD PROGRESSION: 2000-2012

                   52                                                                      MAB gains set new
                                  USDA AVERAGE YIELD/AC1
                                                                                           trajectory on top of
                                  TREND LINE OF USDA YIELD
                   50                                                                      Roundup RReady2Yield
                                                                                           step change
                                  SOYBEAN YIELD AT HISTORIC
                   48             RATE GAIN                                                Roundup
   AVERAGE YIELD




                                                                                           RReady2Yield creates
                                  EXPECTED TREND WITH APPLIED
                                                                                           step change of 7-11%
     (BU/ACRE)




                   46             MOLECULAR BREEDING (MAB)
                                                                                           across portfolio
                   44

                   42
                                                                                           All breeding going
                   40                                                                      forward is built on
                                                                                           Roundup RReady2Yield
                                                                        MAB-ROUNDUP
                                           HISTORIC GAIN: 0.50 BU/AC
                   38                                                                      foundation and uses
                                                                        RREADY2YIELD
                                                                                           applied MAB
                                                                        PLATFORM
                                                                                           technology
                   36
                        2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

                                                              2007      2009-2010
                         Asgrow germplasm shows yield                   Roundup RReady2Yield
                         advantage in all zones based on                controlled commercial
                        greater than 16,000 comparisons,                release + commercial
                        with an average advantage of 1.27               launch
                               bu/acre for groups 1 thru 5

                                                                                                                  10
1. USDA NASS: http://www.nass.usda.gov/QuickStats/
BIOTECH PIPELINE

Phase Advancements For Key Projects Reflect Progress and
Strength Throughout Monsanto’s Industry-Leading Pipeline
 BIOTECH TRAIT PIPELINE: JANUARY 2008 UPDATE
                                                                                                                                                    PHASE     PHASE   PHASE   PHASE
                                                   PHASE     PHASE      PHASE     PHASE
                                                                                                                                           D
                                           D                                                                                                          1         2      3       4
                                                     1         2          3         4
                                                                                                 AGRONOMIC TRAITS
YIELD AND STRESS PIPELINE

                                                                                                  ROUNDUP RREADY2YIELD SOYBEANS
DROUGHT-TOLERANT CORN
FAMILY
                                                                                                                   YIELDGARD VT PRO
                                                                                                           2ND-GEN YIELDGARD CORN BORER
          DROUGHT-TOLERANT CORN
                                                                                                                    SMARTSTAX CORN
  2ND-GEN DROUGHT-TOLERANT CORN
                                                                                                       DICAMBA-TOLERANT SOYBEANS
NITROGEN-UTILIZATION CORN
FAMILY                                                                                                INSECT-PROTECTED + ROUNDUP
                                                                                                           RREADY2YIELD SOYBEANS
       NITROGEN-UTILIZATION CORN
                                                                                                                         BOLLGARD III
BROAD-ACRE HIGHER-YIELDING
CORN FAMILY                                                                                         SOYBEAN NEMATODE-RESISTANCE
             HIGHER-YIELDING CORN                                                                                   SOYBEAN DISEASE

BROAD-ACRE HIGHER-YIELDING                                                                               DICAMBA-TOLERANT COTTON
SOYBEAN FAMILY
                                                                                                            COTTON LYGUS CONTROL
        HIGHER-YIELDING SOYBEANS
                                                                                                            YIELDGARD ROOTWORM III
           2ND-GEN HIGHER-YIELDING
                        SOYBEANS

                                                                                                 VALUE-ADDED TRAITS
DROUGHT-TOLERANT COTTON
FAMILY
       DROUGHT-TOLERANT COTTON                                                                          EXTRAX™ CORN PROCESSING
                                                                                                     SYSTEM + MAVERA™ HIGH-VALUE
                                                                                                                CORN WITH LYSINE2
BROAD-ACRE HIGHER-YIELDING
CANOLA FAMILY
                                                                                                                  HIGH-OIL SOYBEANS
       HIGHER-YIELDING + ROUNDUP
           RREADY2YIELD CANOLA1                                                                           2ND-GEN HIGH-OIL SOYBEANS

                                                                                                       OMEGA-3 ENRICHED SOYBEANS

                                                                                                                VISTIVE III SOYBEANS
                  High Impact Technologies (HIT) project
                                                                                                           HIGH-STEARATE SOYBEANS
                   Jan. 3, 2008 Advancements/Additions                                                                (VIA BIOTECH)
The colored bar associated with each project indicates which phase that project is in. It is                           HIGH-OIL CORN
not intended to represent the relative status of the project within a particular stage.


1. For higher-yielding + Roundup RReady2Yield canola, only the value of the higher-yielding trait is incorporated into the Yield and Stress collaboration with BASF
2. Value of licensing the EXTRAX™ technology is shared with Cargill as a part of Renessen joint venture
                                                                                                                                                                                      11
BIOTECH PIPELINE


     Lead Drought-Tolerant Corn Project Advances to Phase 3
     With Fourth Year of Strong Field Results
                                                                                                       FOURTH SEASON OF YIELD
                 R&D Pipeline                                              NEW:
                                                                                                       IMPROVEMENT UNDER DROUGHT STRESS
Drought-Tolerant Corn Family:
                                                                                                          Average Yield Improvement of Lead Event
Lead Project
                                      ADVANCED:
     HIT Project                                                                                16
                                       Phase 3                                                                           Percentage yield difference vs. control
                                                                                                          13.4%              6.7%         10.6%          11.3%
                                                                                                14
PROJECT CONCEPT:



                                                                   Yield Difference (bu/acre)
                                                                                                12
Drought-tolerance family aimed at
providing consistent yield and
                                                                                                10
buffering against effects of water                                                                                                                                   PRODUCT
limitations                                                                                                                                                          CONCEPT
                                                                                                8                                                                    TARGET
VALUE:                                                                                                                                                               RANGE
                                                                                                6
 LAUNCH-COUNTRY
                                          55M
         ACRES1:
                                                                                                4
                                   $300-$500M
         2020 VALUE2:
                                                                                                2
SOURCES OF VALUE:
                                                                                                0
       Improved yield                                                                                           a                   b             b              b
                                                                                                          2004               2005         2006           2007
       Targeting 8-10% yield                                                                            8 TOTAL           15 TOTAL        9 TOTAL        11 TOTAL
 1     improvement in water-stress                                                                     LOCATIONS         LOCATIONS       LOCATIONS      LOCATIONS
       environments
                                                                                                a: data from two hybrids
1. Acre opportunity reflects acres where technology fits at                                     b: data from three hybrids
   Monsanto's current 2007 market share in respective crops
2. 2020 value reflects gross sales opportunity in launch country
                                                                                                     Drought-tolerant corn lead consistently delivering yield
   in year 2020
                                                                                                     improvements under drought conditions in U.S. for
                                                                                                     fourth year in a row

                                                                                                                                                                               12
BIOTECH PIPELINE


        2007 Dryland Field Tests of Lead Drought Event Offers Visual
        Evidence of Increased Yield In Stressed Conditions
                                                                            2007 FIELD TESTING SHOWS VISUAL
                    R&D Pipeline                                   NEW:
                                                                            PROOF OF YIELD IMPROVEMENT
   Drought-Tolerant Corn Family:
                                                                             SUPERIOR, NE - FIELD TRIALS – 2007
   Lead Project
                                         ADVANCED:
        HIT Project                      Phase 3
   PROJECT CONCEPT:

   Drought-tolerance family aimed at
   providing consistent yield and
   buffering against effects of water
   limitations
   VALUE:
    LAUNCH-COUNTRY
                                             55M
            ACRES1:

                                     $300-$500M
            2020 VALUE2:

   SOURCES OF VALUE:

          Improved yield
          Targeting 8-10% yield                                     CONTROL HYBRID                           WITH GENE
    1     improvement in water-stress
                                                                          (76 BU/AC)                          (94 BU/AC)
          environments
1. Acre opportunity reflects acres where technology fits at
                                                                    Water stress exposure during different stages of
   Monsanto's current 2007 market share in respective crops
                                                                    development can have significant effect on corn yield;
2. 2020 value reflects gross sales opportunity in launch country
                                                                    Monsanto’s lead drought-tolerance trait shows a significant
   in year 2020

                                                                    yield advantage compared with controls under drought
                                                                    stress
                                                                                                                                  13
BIOTECH PIPELINE


      Second-Generation Drought-Tolerant Corn Advances to
      Phase 2 With Multi-Year Performance in Field Testing
                                                                                                                SECOND-GEN DROUGHT CORN EVENTS
                                                                             NEW:
                  R&D Pipeline
                                                                                                                PROVIDE CONSISTENT YIELD ADVANTAGE
 Drought-Tolerant Corn Family:
                                                                                                                   Drought Efficacy for Second-Gen Events




                                                                     Yield Difference Over Controls (%)
 Second-Generation Project
                                                                                                           16
                                        ADVANCED:
                                                                                                           14
                   STATUS:
                                        Phase 2
                                                                                                           12
 PROJECT CONCEPT:

                                                                                                           10
 Drought-tolerance family aimed at
                                                                                                                                                                                 PRODUCT
 providing consistent yield and                                                                                                                                                  CONCEPT
                                                                                                            8
 buffering against effects of water                                                                                                                                              TARGET
                                                                                                                                                                                 RANGE
 limitations                                                                                                6
 VALUE:
                                                                                                            4
   LAUNCH-COUNTRY
                                           55M                                                              2
           ACRES1:

                                                                                                            0
                                    $300-$500M
          2020 VALUE2:
                                                                                                                EVENT 1 EVENT 2 EVENT 3    EVENT 1 EVENT 2 EVENT 3
                                                                                                                    LOWER-YIELDING             HIGHER-YIELDING
 SOURCES OF VALUE:
                                                                                                                     ENVIRONMENT                ENVIRONMENT
                                                                                                                 AVERAGE YIELD: 53 BU/AC   AVERAGE YIELD: 166 BU/AC
        Improved yield
                                                                                                                                                  2007
                                                                                                                        2006
        Targeting 8-10% yield
  1     improvement in water-stress
                                                                   (All three events significant @ p≤0.10); Statistical significance determined by ANOVA (2006) or nonparametric test (2007)
        environments
                                                                                                          Consistent drought yield performance of top 3 events over 2
        Water substitution
                                                                                                          years (5 locations/year)
  2     Variable costs in pumped
        irrigation of >$100/ acre
                                                                     • Performance demonstrated in 2 different test hybrids and over
1. Acre opportunity reflects acres where technology fits at
                                                                       a broad range of drought-stress conditions in both lower-
   Monsanto's current 2007 market share in respective crops

                                                                       yielding and higher-yielding environments (52-188 bu/ac)
2. 2020 value reflects gross sales opportunity in launch country
   in year 2020

                                                                                                                                                                                               14
BIOTECH PIPELINE


      In Continued Field Testing, Nitrogen Utilization Leads Show
      Yield Improvement Under Normal Nitrogen
                                                                                                     LEAD PERFORMANCE UNDER NORMAL
                                                                                        NEW:
                  R&D Pipeline
                                                                                                     NITROGEN CONDITIONS
 Nitrogen-Utilization Corn Family:




                                                              Yield Increase (bu/Ac)
 Lead Project
                                                                                       12
                                                                                                 *                                              **
                                       Phase 1                                         10
                  STATUS:

                                                                                                                                                                   ***
                                                                                                                                      *
                                                                                         8
 PROJECT CONCEPT:
                                                                                         6
                                                                                         4
 Targets ways to use nitrogen more
                                                                                         2
 efficiently, exploring potential to
                                                                                         0
 boost yield under normal nitrogen
                                                                                        -2
 conditions or stabilize it in low
                                                                                                                                            TRIALS IN MULTIPLE
                                                                                                                         TRIALS IN MULTIPLE
 nitrogen environments
                                                                                                                        HYBRID BACKGROUNDS HYBRID BACKGROUNDS
 VALUE:                                                                                                                                          (15 LOC)
                                                                                                                              (16 LOC)
  LAUNCH-COUNTRY                                                                                2005
                                          55M                                                                        2006 YIELD TRIALS:
          ACRES1:                                                                                                                                          2007 YIELD TRIALS:
                                                                                               YIELD
                                                                                                                    SUFFICIENT N LEVELS                   SUFFICIENT N LEVELS
                                                                                              TRIALS:
                                   $300-$500M
          2020 VALUE2:                                                                                                 (37 LOC TOTAL)                        (20 LOC TOTAL)
                                                                                              (23 LOC
                                                                                              TOTAL)
 SOURCES OF VALUE:
                                                                                             2005                         2006                                    2007
        Improved yield
                                                                                             *
        Yield improvement in normal
  1                                                                                              Statistically significant @ p≤0.10
        nitrogen environments                                                                Bar color correlates with the specific hybrid background tested. Same bar color
                                                                                             in different tests and different years indicates same hybrid was used.
        Nitrogen reduction
  2                                                                                          All trials conducted under sufficient nitrogen application levels.
        Improving yield in low nitrogen
        environments
                                                                                             Under normal nitrogen conditions, lead Nitrogen-Utilization
1. Acre opportunity reflects acres where technology fits at
                                                                                             trait has demonstrated yield advantages in multiple
   Monsanto's current 2007 market share in respective crops
                                                                                             backgrounds over multiple years
2. 2020 value reflects gross sales opportunity in launch country
   in year 2020


                                                                                                                                                                                15
BIOTECH PIPELINE


    YieldGard VT PRO Will Provide Dual Mode of Action for
    Increased Product Durability and Broader Spectrum Control
                                                                                 YIELDGARD VT PRO IN FINAL
                                                                NEW:
           R&D Pipeline
                                                                                 REGULATORY PHASE
YieldGard VT PRO
                                                                               2007 YieldGard VT PRO Field Trials
                                                                         12                                                   YieldGard VT PRO
                         Phase 4




                                          # of Damaged Kernels per Ear
          STATUS:
                                                                                 Corn Earworm Damage Ratings                  contains two
                                                                         10
PROJECT CONCEPT:                                                                                                              proteins for effective
                                                                         8                                                    control of target
                                                                                                  2007; N=9
YieldGard VT PRO is the second-
                                                                                                                              insect pests:
                                                                         6
generation of YieldGard Corn Borer
                                                                                                                                  European
and broadens the spectrum of                                             4
                                                                                                                                  cornborer and
insect control and increases the
                                                                                                                                  southwestern
                                                                         2
durability of the trait with the use of
                                                                                                                                  cornborer
two proteins for dual modes of                                           0
                                                                                                                                  Corn earworm
action for resistance management                                              Roundup YieldGard Herculex® YieldGard VT
                                                                                                                                  and fall
                                                                                                     with
                                                                               Ready Corn Borer             Pro with
VALUE:                                                                         Corn 2 with Roundup Roundup                        armyworm
                                                                                                            Roundup
                                                                                       Ready Corn 2 Ready      Ready Corn 2
    LAUNCH-COUNTRY                                                                                                            Provides broader
                           60-65M                                                                   Corn 2
             ACRES:
                                                                                                                              spectrum and
                                                                                                                              greater consistency
                                                                              2007 & 2006 YieldGard VT Pro Field Trials
                        SMARTSTAX
                                            0-9 Damage Rating Scale




         2020 VALUE:                                                     10
                        COMPONENT                                                                                             Awaiting final
                                                                                  Fall Armyworm Damage Ratings
                                                                          9
                                                                                                                              regulatory import
                                                                          8
SOURCES OF VALUE:
                                                                                                                              approvals in key
                                                                                                          2006; N=3
                                                                          7
                                                                                                                              countries, EPA
     Higher per-acre yield from                                           6
                                                                                                          2007; N=5           registration and
     improved spectrum and
1                                                                         5
                                                                                                                              USDA deregulation
     consistency of control                                               4
                                                                          3
     Higher on-farm yield from                                            2
     potential for reduced
2                                                                         1
     refuge acre requirements                                             0
                                                                                 Control      Herculex®      YieldGard VT
                                                                                                                 PRO
                                                                                                                                                       16
BIOTECH PIPELINE


   Third-Generation Corn Rootworm Technology Shows Early
   Promise and Highlights Innovation in the Pipeline
                                                                                RNAi AND NOVEL PROTEIN APPROACHES
             R&D Pipeline
                                                                                DEMONSTRATE EXCELLENT PROTECTION
                                                  NEW:
                                                                                AGAINST CORN ROOTWORM FEEDING
YieldGard Rootworm III
                            Phase 1
             STATUS:
                                                                                1.40
                                                                                           2007 Field Efficacy Tests




                                                      Root Damage (0-3) Scale
PROJECT CONCEPT:
                                                                                1.20               5 locations
YieldGard Rootworm delivers
effective and consistent in-plant                                               1.00
protection against western,
northern and Mexican corn                                                       0.80
rootworm. Third generation
technology, namely RNAi                                                         0.60
technology, is targeted to provide
an additional mode of action for                                                0.40
improved spectrum and durability.
                                                                                0.20

                                                                                0.00
High Pressure Greenhouse Test                                                       YieldGard RNAi 1   RNAi 2 New Insect Negative
                                                                                                               Control
                                                                                  VT Rootworm/
                RNAi                  Negative
                                                                                                                Protein
             Technology                Check
                                                                                 Roundup Ready 2
 YieldGard
Rootworm x
                                                   RNAi technology is an innovative approach that uses targeted
                          YieldGard
   RNAi
                          Rootworm
Technology
                                                   regulation of gene expression for rootworm control
                                                   (Baum JA, et al. Nature Biotechnology; 2007,25, 1322-1325)

                                                 ► Early yield trials demonstrate yield equivalency for both RNAi
                                                   and novel protein constructs

                                                                                                                                    17
BIOTECH PIPELINE


Roundup RReady2Yield Soybean Approaching Commercialization;
Will Serve As Platform for Soybean Trait Pipeline
                                                                                                      FOUR YEARS OF DATA CONTINUE TO
                                                              NEW:
                R&D Pipeline
                                                                                                      VALIDATE 7-11% YIELD ADVANTAGE
Roundup RReady2Yield Soybeans
                                                                                                                  Near-Isoline Comparisons:
    HIT Project                       Phase 4                                                              Roundup RReady2Yield vs. Roundup Ready




                                                               % Yield Increase over Roundup Ready
                                                                                                     12%
PROJECT CONCEPT:

Roundup RReady2Yield provides
                                                                                                            11%
                                                                                                     10%
enhanced yield, with a target of 7-
                                                                                                                                              9%
11% yield increase compared with
Roundup Ready soybeans                                                                                                        9%
                                                                                                     8%
VALUE:
                                                                                                                     7%               7%
LAUNCH-COUNTRY                                                                                       6%
                                         45M
        ACRES1:

                                  $300-$500M
        2020 VALUE2:
                                                                                                     4%
SOURCES OF VALUE:
                                                                                                     2%
      Improved yield
1     Targeting 7-11% yield increase
                                                                                                     0%
                                                                                                                                             4 YEAR
1. Acre opportunity reflects acres where technology fits at
                                                                                                            2004    2005     2006    2007
   Monsanto's current 2007 market share in respective
                                                                                                                                            AVERAGE
   crops
2. 2020 value reflects gross sales opportunity in launch
                                                               Roundup RReady2Yield soybeans yield 7 to 11 percent higher
   country in year 2020

                                                               than Roundup Ready soybeans based on 73 Monsanto field
                                                               trials from 2004-2007



                                                                                                                                                      18
BIOTECH PIPELINE

    Insect-Protected Soybeans Are First-Ever Monsanto Trait
    Developed Exclusively for Non-U.S. Opportunity
                                                                                  FIELD PERFORMANCE OF BT SOYBEANS
                                              NEW:
           R&D Pipeline
Insect-Protected Soybeans with                                                        2007 Insect Efficacy Trials - 4 Locations
Roundup RReady2Yield                                                         50




                                      (season cumulative) ± standard error
                        ADVANCED:                                            45
          STATUS:
                        Phase 3




                                          Mean Larvae per Meter Row
                                                                             40
PROJECT CONCEPT:
                                                                             35
Insect-protected soybeans use Bt                                             30
technology widely adopted in corn                                            25
and cotton to control insect pests,
                                                                             20
especially economically important
                                                                             15
pests for Brazilian farmers. The Bt
trait is combined with Roundup                                               10
RReady2Yield
                                                                             5
VALUE:                                                                       0
                                                                                    UNSPRAYED     SPRAYED         UNSPRAYED                   SPRAYED
    LAUNCH-COUNTRY:        Brazil
                                                                                            Bt                               Non-Bt
  LAUNCH-COUNTRY                                                                                                               non-Bt
                            50M
ACRE OPPORTUNITY1:
                                                                                                      Maturity Group V
    2020 COMMERCIAL
                       $150-$300M
             VALUE2:                                                         Tifton, GA     Loxley, AL       St. Gabriel, LA                  Alexandria, LA
SOURCES OF VALUE:                                                    Insect-protected soybeans with Roundup RReady2Yield
                                                                     technology provides effective protection against key
     Insecticide substitution
                                                                     lepidopteran pests, better than chemical insecticides
1    Based on 2 current sprays
     costing almost $6/acre total
                                              • Also exhibits the glyphosate tolerance of Roundup
     Improved yield                             RReady2Yield soybean varieties
     Early indications of 4+%
2                                     1. Acre opportunity reflects acres where trait could have technological fit. Opportunity does not reflect acres that may be
     increase over chemical              planted to a competitive trait or acres required for insect-resistance management (IRM) set-aside refuges
     insecticides                     2. 2020 value reflects gross sales opportunity in launch country in year 2020

                                                                                                                                                                    19
BIOTECH PIPELINE


    Insect-Protected Soybeans Are First-Ever Monsanto Trait
    Developed Exclusively for Non-U.S. Opportunity
                                                        2007 FIELD TESTING SHOWS VISUAL
           R&D Pipeline                  NEW:
                                                        PROOF OF CONTROL
Insect-Protected Soybeans with
                                                    TIPTON, GA - FIELD EFFICACY TRIAL – 2007
Roundup RReady2Yield
                        ADVANCED:
          STATUS:
                        Phase 3
PROJECT CONCEPT:
Insect-protected soybeans use Bt
technology widely adopted in corn
and cotton to control insect pests,
especially economically important
pests for Brazilian farmers. The Bt
trait is combined with Roundup
RReady2Yield
VALUE:
    LAUNCH-COUNTRY:        Brazil
  LAUNCH-COUNTRY
                            50M
ACRE OPPORTUNITY1:

                                                               CONTROL                                                WITH GENE
    2020 COMMERCIAL
                       $150-$300M
             VALUE2:
                                                          (NO INSECTICIDE)                                        (NO INSECTICIDE)
SOURCES OF VALUE:

     Insecticide substitution                  Insect-protected soybeans with Roundup RReady2Yield
1    Based on 2 current sprays                technology demonstrated significant protection from key
     costing almost $6/acre total
                                              lepidopteran pests, including soybean looper, in 2007 tests
     Improved yield
2    4+% increase over chemical       1. Acre opportunity reflects acres where trait could have technological fit. Opportunity does not reflect acres that may be
                                         planted to a competitive trait or acres required for insect-resistance management (IRM) set-aside refuges
     insecticides
                                      2. 2020 value reflects gross sales opportunity in launch country in year 2020

                                                                                                                                                                    20
BIOTECH PIPELINE


    Dicamba-Tolerant Soybeans Advance to Phase 3 With
    Excellent Tolerance and Yield Data From 2007 Field Trials
                                                                           FIELD PERFORMANCE DEMONSTRATES
                                                              NEW:
                R&D Pipeline
                                                                           EXCELLENT DICAMBA TOLERANCE
Dicamba-Tolerant Soybeans
                                                                                       2007 Efficacy Yield
                                     ADVANCED:
                                                                      80
               STATUS:
                                     Phase 3
PROJECT CONCEPT:
                                                                      60
Provide new, unique mode of

                                                      Yield (bu/ac)
action, designed to provide
                                                                                                                 Untreated
soybean growers with most
                                                                      40
effective weed management system
                                                                                                                 1x1 lb/ac, 2x
available when stacked with
                                                                                                                 2x2 lb/ac, 4x
Roundup RReady2Yield
                                                                                                                 1x1x1 lb/ac, 3x
                                                                      20
VALUE:
  LAUNCH-COUNTRY
                                            45M
ACRE OPPORTUNITY1:

                                                                       0
    2020 COMMERCIAL
                                        <$150M
             VALUE2:                                                       EVENT 1       EVENT 2      EVENT 3
SOURCES OF VALUE:                                                                                               ▼ DMO Enzyme
                                                                                                                   Structure
      Increased Flexibility                                                Agronomic trials in 28 locations
1                                                                          showed comparable yields
      Improved weed control options
      with two modes of action                                             between dicamba treated plots
                                                                           and untreated controls, even at
1. Acre opportunity reflects acres where technology
                                                                           application 3X approved rates –
   fits at Monsanto's current 2007 market share in
   respective crops
                                                                           indicating commercial tolerance
2. 2020 value reflects gross sales opportunity in
                                                                           and yield performance
   launch country in year 2020




                                                                                                                               21
BIOTECH PIPELINE

    Vistive III Advanced to Phase 3 After Meeting Compositional
    and Yield Targets
                                                                             VISTIVE III COMPOSITION TARGETS
                                                       NEW:
            R&D Pipeline
Vistive III Soybeans                                                                                              77%                     Mid Oleic – Low Sat Trait
                                                                            84%
                                                                                                                                          Alone
                                                                            77%
                          ADVANCED:




                                                           Fatty Acid (%)
     HIT Project                                                                                                                          Vistive III Low Lin – Mid
                             Phase 3                                        70%                                                           Oleic – Low Sat
                                                                            63%                                                           Vistive Low Lin Alone
PROJECT CONCEPT:
                                                                            56%
Vistive III trait is designed, by                                           49%
combining breeding and                                                      42%
biotechnology, to lower linolenic                                           35%
                                                                                                                                        14%
and saturate content while boosting
                                                                            28%
                                                                                          6%
oleic content to produce an oil with
                                                                                                                                                            3%
                                                                            21%
the same preferable mono-
                                                                            14%
unsaturated fat content as olive oil
                                                                             7%
and the low saturated fat content
found in canola oil                                                               18:0 + 16:0                    18:1                     18:2              18:3
                                                         CATEGORY►
VALUE:                                                                              SATURATES                    OLEIC                  LINOLEIC          LINOLENIC
                                                          COMMODITY
                                                                                       15%                       20%                     56%                8%
    LAUNCH-COUNTRY                                         SOYBEANS
                            15 - 20M
            ACRES1:
                                                                VISTIVE III
                                                                                       <7%                    55-80%                  12-25%               ≤ 3%
                                                                 TARGETS
                             <$150M
         2020 VALUE2:

SOURCES OF VALUE:
                                                         When breeding (green bar) and biotech (yellow bar) are
                                                         combined, Vistive III (red bar) meets all product concept
     Oil replacement value
                                                         compositional targets
     For frying applications and oil
1    blends for baking, roughly 15 -
                                                       • Additionally, 3 years of biotech trait field data in the U.S. and
     20M acres planted for oil used
                                                         Argentina indicate that yield is not statistically different from
     for food
                                                         control
                        1. Acre opportunity reflects acres where technology fits at Monsanto's current 2007 market share in respective crops
                        2. 2020 value reflects gross sales opportunity in launch country in year 2020

                                                                                                                                                                      22
BIOTECH PIPELINE


      Food Prototypes Containing SDA Soybean Oil from Omega-3
      SDA Enhanced Soybeans Meets Consumer Acceptability
                                                                                                         SDA SOYBEAN OIL METS FOOD
                                                                      NEW:
                  R&D Pipeline
                                                                                                         APPLICATION TARGETS
 Omega-3 SDA Enhanced Soybeans




                                                              9= Like Extremely
                                       Phase 3
                 STATUS:
                                                                                                         Consumer Acceptability – Overall Liking
 PROJECT CONCEPT:                                                                                    9
                                                                                                     8                     7.14a 7.14a
 Omega-3 SDA enhanced soybeans
                                                                                                                                               6.6a 6.47 a
                                                                                                          6.59 a 6.53 a
 represent a land-based source of



                                                                                     Liking Rating
                                                                                                     7
 essential Omega-3 fatty acids.
                                                                                                     6
 Targeting 20 percent stearidonic
                                                                                                     5
 acid (SDA) with taste, shelf life and
 oil stability of soybean oil.
                                                              1= Dislike extremely

                                                                                                     4
 VALUE:                                                                                              3
      LAUNCH-COUNTRY                                                                                 2
                                             <1M
              ACRES1:
                                                                                                     1
                                     $300-$500M
             2020 VALUE2:
                                                                                                          Margarine       Yogurt Drink Granola Bar
 SOURCES OF VALUE:
                                                                                                             Control (Soy Oil )              SDA Soy Oil
        High Value Oil
                                                                                                                      a Not Statistically Different
        Product similar to soybean oil
  1     in taste, shelf-life and oil
                                                                                   Recent results show comparable consumer acceptability
        stability, but with the superior
                                                                                   between SDA soy oil and conventional soy oil in margarine
        nutritional profile of fish oil
                                                                                   spreads, yogurt, yogurt drinks and granola bars
                                                                                 ► No significant yield differences between Omega-3 SDA
1. Acre opportunity reflects acres where technology fits at
                                                                                   enhanced lead event and the control over 5 growing seasons
   Monsanto's current 2007 market share in respective
   crops
                                                                                   and 65 locations
2. 2020 value reflects gross sales opportunity in launch
   country in year 2020
                                                                                                                                                             23
BIOTECH PIPELINE


    Higher-Yielding Soybeans Continue to Demonstrate Improved
    Yield Over Conventional Controls
                                                                                            2007 HIGHER-YIELDING SOYBEAN
                                                                       NEW:
                R&D Pipeline                                                                AGRONOMIC TESTING VERSUS CONTROLS
Higher-Yielding Soybeans Family:
                                                                                                                 Percent yield difference vs. control
Lead Project                                                                          6.0




                                                      (Bu/Ac Increase Over Control)
                                                                                              7.1%
                               Phase 2                                                                               6.2%         6.2%
                                                                                                        6.2%                                  6.1%
               STATUS:




                                                        Average Yield Advantage
                                                                                      5.0
PROJECT CONCEPT:                                                                                                                                        PRODUCT
                                                                                                                                                        CONCEPT
                                                                                      4.0
Higher-yielding soybeans aimed at                                                                                                                       TARGET
                                                                                                                                                        RANGE
boosting intrinsic yield potential of
                                                                                      3.0
soybeans through insertion of key
genes
                                                                                      2.0
VALUE:
    LAUNCH-COUNTRY                                                                    1.0
                                           45M
            ACRES1:

                                                                                      0.0
                                    $300-$500M
           2020 VALUE2:
                                                                                            EVENT 1   EVENT 2      EVENT 3     EVENT 4     EVENT 5
SOURCES OF VALUE:
                                                                                                               18 Locations
      Improved yield
                                                                                      More than 60 events were tested at 18 locations, with lead
1     Targeting additive yield to U.S.
                                                                                      events showing strong yield advantages over conventional
      average of 42 bu/ac
                                                                                      controls
                                                                    • Higher-yielding trait will be stacked on top of Roundup
                                                                      RReady2Yield and other soybean-pipeline traits with an
1. Acre opportunity reflects acres where technology
                                                                      additive yield boost
   fits at Monsanto's current 2007 market share in
   respective crops
2. 2020 value reflects gross sales opportunity in
   launch country in year 2020

                                                                                                                                                                  24
BIOTECH PIPELINE


 U.S. Field Testing Identifies Drought-Tolerance Leads in
 Cotton
                                                                     EARLY RESULTS ON DROUGHT-TOLERANT COTTON
                                                       NEW:
        R&D Pipeline                                                 TESTING IN THE U.S.
Drought-Tolerant Cotton                                                Mid-Season                              Late Season
                                                              Halfway, TX – September 2007              Halfway, TX – October 2007
                  Phase 1
        STATUS:

PROJECT CONCEPT:

Drought-tolerant cotton is
designed to minimize risk in
cotton farming by providing
yield stability in environments
experiencing sporadic or                                                          CONTROL
                                                              WITH GENE                                                     CONTROL
                                                                                                        WITH GENE
consistent water stress and by
reducing water needs on
irrigated acres.
                                  YIELD DIFFERENCE PERCENT




                                                                        Percent yield difference vs. control – Across multiple locations
PROJECT UPDATE:                                                     4.0% 19%       6.7%     8.5%       10.1% 4.7%          4.6% 4.9%
                                                              20
                                     (lbs seed cotton/ACRE)




• Building a portfolio of genes                               18
  that confer drought tolerance                                                                                                 Event 1
                                                              16
  in cotton
                                                              14                                                                Event 2
• Initial field results show                                  12
  positive phenotypes for                                                                                              2006 – 4 locations
                                                              10
  multiple genes in water-                                                                                             2007 – 7-9 locations
                                                              8
  stressed conditions
                                                              6
                                                              4
                                                              2
                                                              0
                                                                          2006         2007                 2006              2007
                                                                           Water Stressed                     Non-Stressed
                                                                                                                                              25
BIOTECH PIPELINE


   Strong Pipeline Reflects Growing Innovation, Opportunity in
   Latter-Stage Projects and Emerging Value in Yield and Stress
                                                                            2020          COUNTRY     ADDITIONAL
                                                             PHASE       COMMERCIAL          OF      GEOGRAPHIC          SOURCES OF VALUE
                                                                           VALUE           LAUNCH    OPPORTUNITY

                                                                                                                   • Improved yield
                                                                                                         BRAZIL
                                                                             HIGH
                                                             3 LEAD
                            Drought-Tolerant Corn Family                                   U.S.        ARGENTINA
YEILD & STRESS




                                                                                                                   • Water replacement
                                                                                                          EU 27

                                                                                                                   • Improved yield
                                                                                                         BRAZIL
                                                                             HIGH
                                                             1 LEAD
                          Nitrogen-Utilization Corn Family                                 U.S.        ARGENTINA
                                                                                                                   • Nitrogen replacement
                                                                                                          EU 27

                                                                                                         BRAZIL
                                                                             MEGA
                                                             2 LEAD
                  Broad-Acre, Higher-Yielding Corn Family                                  U.S.                    • Improved yield
                                                                                                       ARGENTINA
                                                                                                          EU 27

                     Broad-Acre, Higher-Yielding Soybean                     HIGH                        BRAZIL
                                                             2 LEAD                        U.S.                    • Improved yield
                                                                                                       ARGENTINA
                                                   Family
                                                                             HIGH                        BRAZIL
                                                                4
                        Roundup RReady2Yield Soybeans                                      U.S.                    • Improved yield
                                                                                                       ARGENTINA

                                                                                                                   • Improved yield
                                                                                                         BRAZIL
                                                                             HIGH
                                                                4                          U.S.        ARGENTINA
                                       YieldGard VT PRO
                                                                                                                   • Improved insect protection
                                                                                                          EU 27


                                                                             LOW
                                                                4
                              Improved-Protein Soybeans                                    U.S.                    • Food industry functionality
                                                                                                          N/A


                                                                             LOW                         BRAZIL
                                                                3
                                       High-Oil Soybeans                                   U.S.                    • Food industry functionality
                                                                                                       ARGENTINA

                                                                             HIGH
                                                                3
                                      Omega-3 Soybeans                                     U.S.                    • Food industry functionality
                                                                                                          N/A


                                                                                                                   • Improved yield
                              Insect Protected + Roundup
                                                                             MID
                                                                3                          Brazil      ARGENTINA
                                 RReady2Yield Soybeans                                                             • Improved insect protection
                                                                             LOW                         BRAZIL
                                                                3
                              Dicamba-Tolerant Soybeans                                    U.S.                    • Durable weed control
                                                                                                       ARGENTINA

                                                                             LOW
                                                                3
                                      Vistive III Soybeans                                 U.S.                    • Food industry functionality
                                                                                                          N/A

                                                                                                         INDIA
                                                                             MID
                                                                2
                                       Bollgard III Cotton                                 U.S.                    • Improved insect protection
                                                                                                       AUSTRALIA
                                                                                                        BRAZIL

                                                                             LOW                          U.S.
                                                                2
                           Roundup RReady2Yield Canola                                    Canada                   • Improved yield
                                                                                                         EU 27



                 COMMERCIAL VALUE RANGES AT 2020:
                  LOW    <$150M            MID     $150-$300M         HIGH   $300-$500M       MEGA    >$1B



                                                                                                                                                   26
SUMMARY

 Our Biotech and Breeding Pipeline Is Accelerating, With
 Progress in Projects and Widening Yield Advantages

                                                                  MILESTONES:
                                                       Biotech pipeline is accelerating
                                                        10 projects either advanced phases or
                                                        were added to the pipeline – among the
                                                        most in any annual update
                       Q1     Q4                        First time transitioned 4 projects from
                                                        Phase 2 to Phase 3
                       Q2     Q3                        First multi-generational advancement as 2
                                                        generations of corn drought family
                                                        advance
                                                        SmartStax enters the pipeline as the
                                                        platform for corn, complementing
                                                        Roundup RReady2Yield as the soybean
                                                        platform
     ANNUAL R&D CYCLE: SEEDS & TRAITS
                                                       Breeding programs yields impressive
 WHAT CHANGED 2007-2008?
                                                        DEKALB germplasm maintains impressive
 • 5 projects advanced phases                           8.4 bu/ac advantage; gap widens to 14.6
 • 5 products were added                                bu/ac when protected with YieldGard VT
 • Vistive II was removed in favor of Vistive III       Triple stack
 • “Water-use efficiency” soybeans reclassified as
                                                        Asgrow germplasm yield advantage
   “2nd-Gen Higher-yielding soybeans”
                                                        improves to average 1.27 bu/ac; Roundup
 • Two former Renessen projects were rolled into the
                                                        RReady2Yield to provide 7-11% boost
   Monsanto pipeline

                                                                                                    27
monsanto 01-08-08
monsanto 01-08-08

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monsanto 01-08-08

  • 1. R&D PIPELINE REVIEW TERRY CREWS CFO STEVE PADGETTE, PH.D. VICE PRESIDENT, BIOTECHNOLOGY January 8-9, 2008 1
  • 2. Forward-Looking Statements Certain statements contained in this presentation are quot;forward-looking statements,quot; such as statements concerning the company's anticipated financial results, current and future product performance, regulatory approvals, business and financial plans and other non-historical facts. These statements are based on current expectations and currently available information. However, since these statements are based on factors that involve risks and uncertainties, the company's actual performance and results may differ materially from those described or implied by such forward-looking statements. Factors that could cause or contribute to such differences include, among others: continued competition in seeds, traits and agricultural chemicals; the company's exposure to various contingencies, including those related to intellectual property protection, regulatory compliance and the speed with which approvals are received, and public acceptance of biotechnology products; the success of the company's research and development activities; the outcomes of major lawsuits, including proceedings related to Solutia Inc.; developments related to foreign currencies and economies; successful operation of recent acquisitions; fluctuations in commodity prices; compliance with regulations affecting our manufacturing; the accuracy of the company's estimates related to distribution inventory levels; the company's ability to fund its short- term financing needs and to obtain payment for the products that it sells; the effect of weather conditions, natural disasters and accidents on the agriculture business or the company's facilities; and other risks and factors detailed in the company's most recent periodic report to the SEC. Undue reliance should not be placed on these forward-looking statements, which are current only as of the date of this presentation. The company disclaims any current intention or obligation to update any forward-looking statements or any of the factors that may affect actual results. Trademarks Trademarks owned by Monsanto Company and its wholly-owned subsidiaries are italicized in this presentation. All other trademarks are the property of their respective owners. © 2008 Monsanto Company 2
  • 3. Non-GAAP Financial Information This presentation may use the non-GAAP financial measures of “free cash flow,” earnings per share (EPS) on an ongoing basis and Return on Capital (ROC). We define free cash flow as the total of cash flows from operating activities and investing activities. A non-GAAP EPS financial measure, which we refer to as ongoing EPS, excludes certain after-tax items that we do not consider part of ongoing operations, which are identified in the reconciliation. ROC means net income (without the effect of certain items) exclusive of after-tax interest expenses, divided by the average of the beginning year and ending year net capital employed, as defined in the reconciliation. Our presentation of non-GAAP financial measures is intended to supplement investors’ understanding of our operating performance, not replace net income (loss), cash flows, financial position, or comprehensive income (loss), as determined in accordance with GAAP. Furthermore, these non-GAAP financial measures may not be comparable to similar measures used by other companies. The non-GAAP financial measures used in this presentation are reconciled to the most directly comparable financial measures calculated and presented in accordance with GAAP. Monsanto is unable to provide a reconciliation of the 2008 ROC goal to projected net income and financial position for 2008 without unreasonable effort. As shown in the ROC reconciliation for the previous year, the calculation of ROC is complex, and Monsanto does not have sufficient information at this point in the fiscal year to reasonably estimate its operating profit after-tax and average capital for 2008 due to market and other conditions that are outside of Monsanto’s control. With respect to the time period prior to Sept. 1, 2000, references to Monsanto in this presentation also refer to the agricultural business of Pharmacia. FISCAL YEAR: References to year, or to fiscal year, are on a fiscal year basis and refer to the 12-month period ending August 31. 3
  • 4. FINANCIAL REVIEW 2008 Again Projects Double-Digit Earnings Growth, Strong Cash Generation and Improved Margins 2007 2008F EARNINGS $2.00 $2.50-$2.60 ONGOING EARNINGS PER SHARE 54% GROWTH 25-30% GROWTH FROM 2006 FROM 2007 Further progress on Gross Profit as a Percent of Sales 50% trajectory toward 52-54% 2010 target Seeds & Traits Gross Profit $3.0B ~$3.5B Roundup And All Other Glyphosate-based $854M Greater than $1B Herbicides Gross Profit All Other Ag Productivity Gross Profit $418M ~$350M CASH MANAGEMENT AND SPENDING FREE CASH FLOW $(57)M $900M-$1B Return on Capital 14.8% Consistent with 2007 levels Capital Expenditures $509M Greater than $800M SG&A as a Percent of Sales 22% 20-21% Range R&D as a Percent of Sales 9% 10% Range Receivables as a Percent of Sales 18% Consistent with 2007 levels Inventories as a Percent of Sales 20% Consistent with 2007 levels 4
  • 5. OVERVIEW Given Growth Opportunities, Monsanto Has Potential to More Than Double Gross Profit Over Next Five Years 2012 GROWTH RANGE MONSANTO GROSS PROFIT GROWTH TARGET Gross profit targeted to double from 2007 through 2012 $9,000 STRATEGIC PLAYBOOK $8,000 All growth is organic, from $7,000 base business and pipeline GROSS PROFIT (IN MILLIONS) $6,000 U.S. Corn International Corn $5,000 Soybeans Cotton $4,000 Seminis $3,000 R&D Pipeline Acquisitions to be pursued, $2,000 but are not included in this $1,000 growth projection Earnings continue to translate $0 into operating cash, and value MILESTONES 2004 2007 2012 created for shareowners 2010 2007 through combination of Gross margin Base Gross Profit: acquisitions, share target: 52-54% $4,286M repurchases and dividends ONGOING EPS GROWTH: MID-TO-HIGH TEENS 5
  • 6. OVERVIEW Our Biotech and Breeding Pipeline Is Accelerating, With Progress in Projects and Widening Yield Advantages MILESTONES: Biotech pipeline is accelerating 10 projects either advanced phases or were added to the pipeline – among the most in any annual update Q1 Q4 First time transitioned 4 projects from Phase 2 to Phase 3 Q2 Q3 First multi-generational advancement as 2 generations of corn drought family advance SmartStax enters the pipeline as the platform for corn, complementing Roundup RReady2Yield as the soybean platform ANNUAL R&D CYCLE: SEEDS & TRAITS Breeding programs yields impressive WHAT CHANGED 2007-2008? DEKALB germplasm maintains impressive • 5 projects advanced phases 8.4 bu/ac advantage; gap widens to 14.6 • 5 products added bu/ac when protected with YieldGard VT • Vistive II removed in favor of Vistive III Triple stack • “Water-use efficiency” soybeans reclassified as Asgrow germplasm yield advantage “2nd-Gen Higher-Yielding soybeans” improves to average 1.27 bu/ac; Roundup • Two former Renessen projects rolled into the Monsanto RReady2Yield to provide 7-11% boost pipeline 6
  • 7. OVERVIEW Pipeline Leverages Power of Breeding and Biotech for Current Commercial Growth and New Platforms in Next Decade MONSANTO’S R&D PIPELINE DISCOVERY PHASE I PHASE II R&D PHASE: PHASE III PHASE IV LAUNCH BREEDING G COMMERCIAL IT PLATFORM GERMPLASM INTEGRATION ANALYTICS COMMERCIAL MARKERS GENOMICS SEED ELITE Germplasm TRAIT SOLD TO R FARMERS BIOTECHNOLOGY Pipeline Priorities Through 2012 Pipeline Priorities Through 2012 BIOTECHNOLOGY BREEDING Deliver the Value in Monsanto’s Established Continue to Drive Breeding Gains Across Crop Trait Pipeline Platforms Unlock the Opportunity in Yield and Stress ► Ensure momentum in corn breeding continues Through the BASF Collaboration ► Accelerate ramp up of soybean breeding ► Continue application of proven tools to cotton and ► Deliver the industry’s first traits in the emerging yield- vegetables and-stress arena ► Change the trait-value opportunity with “product families” 7
  • 8. CORN BREEDING Final Yield Trial Results Reinforce Yield Advantage of DEKALB Seed in U.S. 2007 FINAL U.S. COMPETITIVE CORN YIELD FINAL: COMPARISON: DEKALB DEKALB U.S. GEOGRAPHY: 210 (APPROXIMATE DIFFERENCES) COMPETITORS Grow footprint 205 OBJECTIVE: 205 2007 PERFORMANCE UPDATE 200 BUSHELS/ACRE • In > 14,000 comparisons, 195 197 Monsanto out-yields 195 190 193 competitive best by 191 190 189 185 188 8.4 bu/ac 186 180 • In 110-day RM, Monsanto’s lead remains 179 175 a strong 12 bu/ac 170 advantage 165 Source: 2007 Monsanto 160 and third party trials 163 through November 15, 155 2007. Weighted 155 average, calculated to 150 15% moisture. DEKALB products are compared 95 RM 100 RM 105 RM 110 RM 115 RM Overall with national competitive RELATIVE MATURITIES (DAYS)► products that contain >480 >1,220 >1,820 >5,220 >5,270 >14,000 COMPARISONS: similar crop protection traits. APPROXIMATE BU/AC 7.8 10.4 5.1 12.0 5.5 8.4 ADVANTAGE: 8
  • 9. CORN BREEDING Again in 2007, Best in Class Germplasm and Trait Integration Delivers Best Yield TOTAL DEKALB SEED & TRAIT YIELD PERFORMANCE IN 2007 FINAL Seed & Trait: Head-to-Head AVE. BUSHELS PER ACRE 210 14.6 211.6 206 BU/AC 202 ADVANTAGE 198 197.0 194 190 MONSANTO Pioneer ® Competitive Hybrids DEKALB Hybrids Performance in Key Corn Belt States with Herculex® with YieldGard VT XTRA and Roundup Triple NE IA IL Ready Corn 2 >70 >400 800 Nearly 1,700 comparisons in 17 states: DEKALB Comparisons: seed, protected by YieldGard VT Triple, 210 214 219 Monsanto outperformed the best competitive seed-and- Brands: bu/ac bu/ac bu/ac trait package by >14.6 bu/ac on average 193 200 202 Competitive Brand: bu/ac bu/ac bu/ac 9
  • 10. SOYBEAN BREEDING Roundup RReady2Yield and Molecular Breeding Rewrite Historic Soybean Yield Trends SOYBEAN YIELD PROGRESSION: 2000-2012 52 MAB gains set new USDA AVERAGE YIELD/AC1 trajectory on top of TREND LINE OF USDA YIELD 50 Roundup RReady2Yield step change SOYBEAN YIELD AT HISTORIC 48 RATE GAIN Roundup AVERAGE YIELD RReady2Yield creates EXPECTED TREND WITH APPLIED step change of 7-11% (BU/ACRE) 46 MOLECULAR BREEDING (MAB) across portfolio 44 42 All breeding going 40 forward is built on Roundup RReady2Yield MAB-ROUNDUP HISTORIC GAIN: 0.50 BU/AC 38 foundation and uses RREADY2YIELD applied MAB PLATFORM technology 36 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2007 2009-2010 Asgrow germplasm shows yield Roundup RReady2Yield advantage in all zones based on controlled commercial greater than 16,000 comparisons, release + commercial with an average advantage of 1.27 launch bu/acre for groups 1 thru 5 10 1. USDA NASS: http://www.nass.usda.gov/QuickStats/
  • 11. BIOTECH PIPELINE Phase Advancements For Key Projects Reflect Progress and Strength Throughout Monsanto’s Industry-Leading Pipeline BIOTECH TRAIT PIPELINE: JANUARY 2008 UPDATE PHASE PHASE PHASE PHASE PHASE PHASE PHASE PHASE D D 1 2 3 4 1 2 3 4 AGRONOMIC TRAITS YIELD AND STRESS PIPELINE ROUNDUP RREADY2YIELD SOYBEANS DROUGHT-TOLERANT CORN FAMILY YIELDGARD VT PRO 2ND-GEN YIELDGARD CORN BORER DROUGHT-TOLERANT CORN SMARTSTAX CORN 2ND-GEN DROUGHT-TOLERANT CORN DICAMBA-TOLERANT SOYBEANS NITROGEN-UTILIZATION CORN FAMILY INSECT-PROTECTED + ROUNDUP RREADY2YIELD SOYBEANS NITROGEN-UTILIZATION CORN BOLLGARD III BROAD-ACRE HIGHER-YIELDING CORN FAMILY SOYBEAN NEMATODE-RESISTANCE HIGHER-YIELDING CORN SOYBEAN DISEASE BROAD-ACRE HIGHER-YIELDING DICAMBA-TOLERANT COTTON SOYBEAN FAMILY COTTON LYGUS CONTROL HIGHER-YIELDING SOYBEANS YIELDGARD ROOTWORM III 2ND-GEN HIGHER-YIELDING SOYBEANS VALUE-ADDED TRAITS DROUGHT-TOLERANT COTTON FAMILY DROUGHT-TOLERANT COTTON EXTRAX™ CORN PROCESSING SYSTEM + MAVERA™ HIGH-VALUE CORN WITH LYSINE2 BROAD-ACRE HIGHER-YIELDING CANOLA FAMILY HIGH-OIL SOYBEANS HIGHER-YIELDING + ROUNDUP RREADY2YIELD CANOLA1 2ND-GEN HIGH-OIL SOYBEANS OMEGA-3 ENRICHED SOYBEANS VISTIVE III SOYBEANS High Impact Technologies (HIT) project HIGH-STEARATE SOYBEANS Jan. 3, 2008 Advancements/Additions (VIA BIOTECH) The colored bar associated with each project indicates which phase that project is in. It is HIGH-OIL CORN not intended to represent the relative status of the project within a particular stage. 1. For higher-yielding + Roundup RReady2Yield canola, only the value of the higher-yielding trait is incorporated into the Yield and Stress collaboration with BASF 2. Value of licensing the EXTRAX™ technology is shared with Cargill as a part of Renessen joint venture 11
  • 12. BIOTECH PIPELINE Lead Drought-Tolerant Corn Project Advances to Phase 3 With Fourth Year of Strong Field Results FOURTH SEASON OF YIELD R&D Pipeline NEW: IMPROVEMENT UNDER DROUGHT STRESS Drought-Tolerant Corn Family: Average Yield Improvement of Lead Event Lead Project ADVANCED: HIT Project 16 Phase 3 Percentage yield difference vs. control 13.4% 6.7% 10.6% 11.3% 14 PROJECT CONCEPT: Yield Difference (bu/acre) 12 Drought-tolerance family aimed at providing consistent yield and 10 buffering against effects of water PRODUCT limitations CONCEPT 8 TARGET VALUE: RANGE 6 LAUNCH-COUNTRY 55M ACRES1: 4 $300-$500M 2020 VALUE2: 2 SOURCES OF VALUE: 0 Improved yield a b b b 2004 2005 2006 2007 Targeting 8-10% yield 8 TOTAL 15 TOTAL 9 TOTAL 11 TOTAL 1 improvement in water-stress LOCATIONS LOCATIONS LOCATIONS LOCATIONS environments a: data from two hybrids 1. Acre opportunity reflects acres where technology fits at b: data from three hybrids Monsanto's current 2007 market share in respective crops 2. 2020 value reflects gross sales opportunity in launch country Drought-tolerant corn lead consistently delivering yield in year 2020 improvements under drought conditions in U.S. for fourth year in a row 12
  • 13. BIOTECH PIPELINE 2007 Dryland Field Tests of Lead Drought Event Offers Visual Evidence of Increased Yield In Stressed Conditions 2007 FIELD TESTING SHOWS VISUAL R&D Pipeline NEW: PROOF OF YIELD IMPROVEMENT Drought-Tolerant Corn Family: SUPERIOR, NE - FIELD TRIALS – 2007 Lead Project ADVANCED: HIT Project Phase 3 PROJECT CONCEPT: Drought-tolerance family aimed at providing consistent yield and buffering against effects of water limitations VALUE: LAUNCH-COUNTRY 55M ACRES1: $300-$500M 2020 VALUE2: SOURCES OF VALUE: Improved yield Targeting 8-10% yield CONTROL HYBRID WITH GENE 1 improvement in water-stress (76 BU/AC) (94 BU/AC) environments 1. Acre opportunity reflects acres where technology fits at Water stress exposure during different stages of Monsanto's current 2007 market share in respective crops development can have significant effect on corn yield; 2. 2020 value reflects gross sales opportunity in launch country Monsanto’s lead drought-tolerance trait shows a significant in year 2020 yield advantage compared with controls under drought stress 13
  • 14. BIOTECH PIPELINE Second-Generation Drought-Tolerant Corn Advances to Phase 2 With Multi-Year Performance in Field Testing SECOND-GEN DROUGHT CORN EVENTS NEW: R&D Pipeline PROVIDE CONSISTENT YIELD ADVANTAGE Drought-Tolerant Corn Family: Drought Efficacy for Second-Gen Events Yield Difference Over Controls (%) Second-Generation Project 16 ADVANCED: 14 STATUS: Phase 2 12 PROJECT CONCEPT: 10 Drought-tolerance family aimed at PRODUCT providing consistent yield and CONCEPT 8 buffering against effects of water TARGET RANGE limitations 6 VALUE: 4 LAUNCH-COUNTRY 55M 2 ACRES1: 0 $300-$500M 2020 VALUE2: EVENT 1 EVENT 2 EVENT 3 EVENT 1 EVENT 2 EVENT 3 LOWER-YIELDING HIGHER-YIELDING SOURCES OF VALUE: ENVIRONMENT ENVIRONMENT AVERAGE YIELD: 53 BU/AC AVERAGE YIELD: 166 BU/AC Improved yield 2007 2006 Targeting 8-10% yield 1 improvement in water-stress (All three events significant @ p≤0.10); Statistical significance determined by ANOVA (2006) or nonparametric test (2007) environments Consistent drought yield performance of top 3 events over 2 Water substitution years (5 locations/year) 2 Variable costs in pumped irrigation of >$100/ acre • Performance demonstrated in 2 different test hybrids and over 1. Acre opportunity reflects acres where technology fits at a broad range of drought-stress conditions in both lower- Monsanto's current 2007 market share in respective crops yielding and higher-yielding environments (52-188 bu/ac) 2. 2020 value reflects gross sales opportunity in launch country in year 2020 14
  • 15. BIOTECH PIPELINE In Continued Field Testing, Nitrogen Utilization Leads Show Yield Improvement Under Normal Nitrogen LEAD PERFORMANCE UNDER NORMAL NEW: R&D Pipeline NITROGEN CONDITIONS Nitrogen-Utilization Corn Family: Yield Increase (bu/Ac) Lead Project 12 * ** Phase 1 10 STATUS: *** * 8 PROJECT CONCEPT: 6 4 Targets ways to use nitrogen more 2 efficiently, exploring potential to 0 boost yield under normal nitrogen -2 conditions or stabilize it in low TRIALS IN MULTIPLE TRIALS IN MULTIPLE nitrogen environments HYBRID BACKGROUNDS HYBRID BACKGROUNDS VALUE: (15 LOC) (16 LOC) LAUNCH-COUNTRY 2005 55M 2006 YIELD TRIALS: ACRES1: 2007 YIELD TRIALS: YIELD SUFFICIENT N LEVELS SUFFICIENT N LEVELS TRIALS: $300-$500M 2020 VALUE2: (37 LOC TOTAL) (20 LOC TOTAL) (23 LOC TOTAL) SOURCES OF VALUE: 2005 2006 2007 Improved yield * Yield improvement in normal 1 Statistically significant @ p≤0.10 nitrogen environments Bar color correlates with the specific hybrid background tested. Same bar color in different tests and different years indicates same hybrid was used. Nitrogen reduction 2 All trials conducted under sufficient nitrogen application levels. Improving yield in low nitrogen environments Under normal nitrogen conditions, lead Nitrogen-Utilization 1. Acre opportunity reflects acres where technology fits at trait has demonstrated yield advantages in multiple Monsanto's current 2007 market share in respective crops backgrounds over multiple years 2. 2020 value reflects gross sales opportunity in launch country in year 2020 15
  • 16. BIOTECH PIPELINE YieldGard VT PRO Will Provide Dual Mode of Action for Increased Product Durability and Broader Spectrum Control YIELDGARD VT PRO IN FINAL NEW: R&D Pipeline REGULATORY PHASE YieldGard VT PRO 2007 YieldGard VT PRO Field Trials 12 YieldGard VT PRO Phase 4 # of Damaged Kernels per Ear STATUS: Corn Earworm Damage Ratings contains two 10 PROJECT CONCEPT: proteins for effective 8 control of target 2007; N=9 YieldGard VT PRO is the second- insect pests: 6 generation of YieldGard Corn Borer European and broadens the spectrum of 4 cornborer and insect control and increases the southwestern 2 durability of the trait with the use of cornborer two proteins for dual modes of 0 Corn earworm action for resistance management Roundup YieldGard Herculex® YieldGard VT and fall with Ready Corn Borer Pro with VALUE: Corn 2 with Roundup Roundup armyworm Roundup Ready Corn 2 Ready Ready Corn 2 LAUNCH-COUNTRY Provides broader 60-65M Corn 2 ACRES: spectrum and greater consistency 2007 & 2006 YieldGard VT Pro Field Trials SMARTSTAX 0-9 Damage Rating Scale 2020 VALUE: 10 COMPONENT Awaiting final Fall Armyworm Damage Ratings 9 regulatory import 8 SOURCES OF VALUE: approvals in key 2006; N=3 7 countries, EPA Higher per-acre yield from 6 2007; N=5 registration and improved spectrum and 1 5 USDA deregulation consistency of control 4 3 Higher on-farm yield from 2 potential for reduced 2 1 refuge acre requirements 0 Control Herculex® YieldGard VT PRO 16
  • 17. BIOTECH PIPELINE Third-Generation Corn Rootworm Technology Shows Early Promise and Highlights Innovation in the Pipeline RNAi AND NOVEL PROTEIN APPROACHES R&D Pipeline DEMONSTRATE EXCELLENT PROTECTION NEW: AGAINST CORN ROOTWORM FEEDING YieldGard Rootworm III Phase 1 STATUS: 1.40 2007 Field Efficacy Tests Root Damage (0-3) Scale PROJECT CONCEPT: 1.20 5 locations YieldGard Rootworm delivers effective and consistent in-plant 1.00 protection against western, northern and Mexican corn 0.80 rootworm. Third generation technology, namely RNAi 0.60 technology, is targeted to provide an additional mode of action for 0.40 improved spectrum and durability. 0.20 0.00 High Pressure Greenhouse Test YieldGard RNAi 1 RNAi 2 New Insect Negative Control VT Rootworm/ RNAi Negative Protein Technology Check Roundup Ready 2 YieldGard Rootworm x RNAi technology is an innovative approach that uses targeted YieldGard RNAi Rootworm Technology regulation of gene expression for rootworm control (Baum JA, et al. Nature Biotechnology; 2007,25, 1322-1325) ► Early yield trials demonstrate yield equivalency for both RNAi and novel protein constructs 17
  • 18. BIOTECH PIPELINE Roundup RReady2Yield Soybean Approaching Commercialization; Will Serve As Platform for Soybean Trait Pipeline FOUR YEARS OF DATA CONTINUE TO NEW: R&D Pipeline VALIDATE 7-11% YIELD ADVANTAGE Roundup RReady2Yield Soybeans Near-Isoline Comparisons: HIT Project Phase 4 Roundup RReady2Yield vs. Roundup Ready % Yield Increase over Roundup Ready 12% PROJECT CONCEPT: Roundup RReady2Yield provides 11% 10% enhanced yield, with a target of 7- 9% 11% yield increase compared with Roundup Ready soybeans 9% 8% VALUE: 7% 7% LAUNCH-COUNTRY 6% 45M ACRES1: $300-$500M 2020 VALUE2: 4% SOURCES OF VALUE: 2% Improved yield 1 Targeting 7-11% yield increase 0% 4 YEAR 1. Acre opportunity reflects acres where technology fits at 2004 2005 2006 2007 Monsanto's current 2007 market share in respective AVERAGE crops 2. 2020 value reflects gross sales opportunity in launch Roundup RReady2Yield soybeans yield 7 to 11 percent higher country in year 2020 than Roundup Ready soybeans based on 73 Monsanto field trials from 2004-2007 18
  • 19. BIOTECH PIPELINE Insect-Protected Soybeans Are First-Ever Monsanto Trait Developed Exclusively for Non-U.S. Opportunity FIELD PERFORMANCE OF BT SOYBEANS NEW: R&D Pipeline Insect-Protected Soybeans with 2007 Insect Efficacy Trials - 4 Locations Roundup RReady2Yield 50 (season cumulative) ± standard error ADVANCED: 45 STATUS: Phase 3 Mean Larvae per Meter Row 40 PROJECT CONCEPT: 35 Insect-protected soybeans use Bt 30 technology widely adopted in corn 25 and cotton to control insect pests, 20 especially economically important 15 pests for Brazilian farmers. The Bt trait is combined with Roundup 10 RReady2Yield 5 VALUE: 0 UNSPRAYED SPRAYED UNSPRAYED SPRAYED LAUNCH-COUNTRY: Brazil Bt Non-Bt LAUNCH-COUNTRY non-Bt 50M ACRE OPPORTUNITY1: Maturity Group V 2020 COMMERCIAL $150-$300M VALUE2: Tifton, GA Loxley, AL St. Gabriel, LA Alexandria, LA SOURCES OF VALUE: Insect-protected soybeans with Roundup RReady2Yield technology provides effective protection against key Insecticide substitution lepidopteran pests, better than chemical insecticides 1 Based on 2 current sprays costing almost $6/acre total • Also exhibits the glyphosate tolerance of Roundup Improved yield RReady2Yield soybean varieties Early indications of 4+% 2 1. Acre opportunity reflects acres where trait could have technological fit. Opportunity does not reflect acres that may be increase over chemical planted to a competitive trait or acres required for insect-resistance management (IRM) set-aside refuges insecticides 2. 2020 value reflects gross sales opportunity in launch country in year 2020 19
  • 20. BIOTECH PIPELINE Insect-Protected Soybeans Are First-Ever Monsanto Trait Developed Exclusively for Non-U.S. Opportunity 2007 FIELD TESTING SHOWS VISUAL R&D Pipeline NEW: PROOF OF CONTROL Insect-Protected Soybeans with TIPTON, GA - FIELD EFFICACY TRIAL – 2007 Roundup RReady2Yield ADVANCED: STATUS: Phase 3 PROJECT CONCEPT: Insect-protected soybeans use Bt technology widely adopted in corn and cotton to control insect pests, especially economically important pests for Brazilian farmers. The Bt trait is combined with Roundup RReady2Yield VALUE: LAUNCH-COUNTRY: Brazil LAUNCH-COUNTRY 50M ACRE OPPORTUNITY1: CONTROL WITH GENE 2020 COMMERCIAL $150-$300M VALUE2: (NO INSECTICIDE) (NO INSECTICIDE) SOURCES OF VALUE: Insecticide substitution Insect-protected soybeans with Roundup RReady2Yield 1 Based on 2 current sprays technology demonstrated significant protection from key costing almost $6/acre total lepidopteran pests, including soybean looper, in 2007 tests Improved yield 2 4+% increase over chemical 1. Acre opportunity reflects acres where trait could have technological fit. Opportunity does not reflect acres that may be planted to a competitive trait or acres required for insect-resistance management (IRM) set-aside refuges insecticides 2. 2020 value reflects gross sales opportunity in launch country in year 2020 20
  • 21. BIOTECH PIPELINE Dicamba-Tolerant Soybeans Advance to Phase 3 With Excellent Tolerance and Yield Data From 2007 Field Trials FIELD PERFORMANCE DEMONSTRATES NEW: R&D Pipeline EXCELLENT DICAMBA TOLERANCE Dicamba-Tolerant Soybeans 2007 Efficacy Yield ADVANCED: 80 STATUS: Phase 3 PROJECT CONCEPT: 60 Provide new, unique mode of Yield (bu/ac) action, designed to provide Untreated soybean growers with most 40 effective weed management system 1x1 lb/ac, 2x available when stacked with 2x2 lb/ac, 4x Roundup RReady2Yield 1x1x1 lb/ac, 3x 20 VALUE: LAUNCH-COUNTRY 45M ACRE OPPORTUNITY1: 0 2020 COMMERCIAL <$150M VALUE2: EVENT 1 EVENT 2 EVENT 3 SOURCES OF VALUE: ▼ DMO Enzyme Structure Increased Flexibility Agronomic trials in 28 locations 1 showed comparable yields Improved weed control options with two modes of action between dicamba treated plots and untreated controls, even at 1. Acre opportunity reflects acres where technology application 3X approved rates – fits at Monsanto's current 2007 market share in respective crops indicating commercial tolerance 2. 2020 value reflects gross sales opportunity in and yield performance launch country in year 2020 21
  • 22. BIOTECH PIPELINE Vistive III Advanced to Phase 3 After Meeting Compositional and Yield Targets VISTIVE III COMPOSITION TARGETS NEW: R&D Pipeline Vistive III Soybeans 77% Mid Oleic – Low Sat Trait 84% Alone 77% ADVANCED: Fatty Acid (%) HIT Project Vistive III Low Lin – Mid Phase 3 70% Oleic – Low Sat 63% Vistive Low Lin Alone PROJECT CONCEPT: 56% Vistive III trait is designed, by 49% combining breeding and 42% biotechnology, to lower linolenic 35% 14% and saturate content while boosting 28% 6% oleic content to produce an oil with 3% 21% the same preferable mono- 14% unsaturated fat content as olive oil 7% and the low saturated fat content found in canola oil 18:0 + 16:0 18:1 18:2 18:3 CATEGORY► VALUE: SATURATES OLEIC LINOLEIC LINOLENIC COMMODITY 15% 20% 56% 8% LAUNCH-COUNTRY SOYBEANS 15 - 20M ACRES1: VISTIVE III <7% 55-80% 12-25% ≤ 3% TARGETS <$150M 2020 VALUE2: SOURCES OF VALUE: When breeding (green bar) and biotech (yellow bar) are combined, Vistive III (red bar) meets all product concept Oil replacement value compositional targets For frying applications and oil 1 blends for baking, roughly 15 - • Additionally, 3 years of biotech trait field data in the U.S. and 20M acres planted for oil used Argentina indicate that yield is not statistically different from for food control 1. Acre opportunity reflects acres where technology fits at Monsanto's current 2007 market share in respective crops 2. 2020 value reflects gross sales opportunity in launch country in year 2020 22
  • 23. BIOTECH PIPELINE Food Prototypes Containing SDA Soybean Oil from Omega-3 SDA Enhanced Soybeans Meets Consumer Acceptability SDA SOYBEAN OIL METS FOOD NEW: R&D Pipeline APPLICATION TARGETS Omega-3 SDA Enhanced Soybeans 9= Like Extremely Phase 3 STATUS: Consumer Acceptability – Overall Liking PROJECT CONCEPT: 9 8 7.14a 7.14a Omega-3 SDA enhanced soybeans 6.6a 6.47 a 6.59 a 6.53 a represent a land-based source of Liking Rating 7 essential Omega-3 fatty acids. 6 Targeting 20 percent stearidonic 5 acid (SDA) with taste, shelf life and oil stability of soybean oil. 1= Dislike extremely 4 VALUE: 3 LAUNCH-COUNTRY 2 <1M ACRES1: 1 $300-$500M 2020 VALUE2: Margarine Yogurt Drink Granola Bar SOURCES OF VALUE: Control (Soy Oil ) SDA Soy Oil High Value Oil a Not Statistically Different Product similar to soybean oil 1 in taste, shelf-life and oil Recent results show comparable consumer acceptability stability, but with the superior between SDA soy oil and conventional soy oil in margarine nutritional profile of fish oil spreads, yogurt, yogurt drinks and granola bars ► No significant yield differences between Omega-3 SDA 1. Acre opportunity reflects acres where technology fits at enhanced lead event and the control over 5 growing seasons Monsanto's current 2007 market share in respective crops and 65 locations 2. 2020 value reflects gross sales opportunity in launch country in year 2020 23
  • 24. BIOTECH PIPELINE Higher-Yielding Soybeans Continue to Demonstrate Improved Yield Over Conventional Controls 2007 HIGHER-YIELDING SOYBEAN NEW: R&D Pipeline AGRONOMIC TESTING VERSUS CONTROLS Higher-Yielding Soybeans Family: Percent yield difference vs. control Lead Project 6.0 (Bu/Ac Increase Over Control) 7.1% Phase 2 6.2% 6.2% 6.2% 6.1% STATUS: Average Yield Advantage 5.0 PROJECT CONCEPT: PRODUCT CONCEPT 4.0 Higher-yielding soybeans aimed at TARGET RANGE boosting intrinsic yield potential of 3.0 soybeans through insertion of key genes 2.0 VALUE: LAUNCH-COUNTRY 1.0 45M ACRES1: 0.0 $300-$500M 2020 VALUE2: EVENT 1 EVENT 2 EVENT 3 EVENT 4 EVENT 5 SOURCES OF VALUE: 18 Locations Improved yield More than 60 events were tested at 18 locations, with lead 1 Targeting additive yield to U.S. events showing strong yield advantages over conventional average of 42 bu/ac controls • Higher-yielding trait will be stacked on top of Roundup RReady2Yield and other soybean-pipeline traits with an 1. Acre opportunity reflects acres where technology additive yield boost fits at Monsanto's current 2007 market share in respective crops 2. 2020 value reflects gross sales opportunity in launch country in year 2020 24
  • 25. BIOTECH PIPELINE U.S. Field Testing Identifies Drought-Tolerance Leads in Cotton EARLY RESULTS ON DROUGHT-TOLERANT COTTON NEW: R&D Pipeline TESTING IN THE U.S. Drought-Tolerant Cotton Mid-Season Late Season Halfway, TX – September 2007 Halfway, TX – October 2007 Phase 1 STATUS: PROJECT CONCEPT: Drought-tolerant cotton is designed to minimize risk in cotton farming by providing yield stability in environments experiencing sporadic or CONTROL WITH GENE CONTROL WITH GENE consistent water stress and by reducing water needs on irrigated acres. YIELD DIFFERENCE PERCENT Percent yield difference vs. control – Across multiple locations PROJECT UPDATE: 4.0% 19% 6.7% 8.5% 10.1% 4.7% 4.6% 4.9% 20 (lbs seed cotton/ACRE) • Building a portfolio of genes 18 that confer drought tolerance Event 1 16 in cotton 14 Event 2 • Initial field results show 12 positive phenotypes for 2006 – 4 locations 10 multiple genes in water- 2007 – 7-9 locations 8 stressed conditions 6 4 2 0 2006 2007 2006 2007 Water Stressed Non-Stressed 25
  • 26. BIOTECH PIPELINE Strong Pipeline Reflects Growing Innovation, Opportunity in Latter-Stage Projects and Emerging Value in Yield and Stress 2020 COUNTRY ADDITIONAL PHASE COMMERCIAL OF GEOGRAPHIC SOURCES OF VALUE VALUE LAUNCH OPPORTUNITY • Improved yield BRAZIL HIGH 3 LEAD Drought-Tolerant Corn Family U.S. ARGENTINA YEILD & STRESS • Water replacement EU 27 • Improved yield BRAZIL HIGH 1 LEAD Nitrogen-Utilization Corn Family U.S. ARGENTINA • Nitrogen replacement EU 27 BRAZIL MEGA 2 LEAD Broad-Acre, Higher-Yielding Corn Family U.S. • Improved yield ARGENTINA EU 27 Broad-Acre, Higher-Yielding Soybean HIGH BRAZIL 2 LEAD U.S. • Improved yield ARGENTINA Family HIGH BRAZIL 4 Roundup RReady2Yield Soybeans U.S. • Improved yield ARGENTINA • Improved yield BRAZIL HIGH 4 U.S. ARGENTINA YieldGard VT PRO • Improved insect protection EU 27 LOW 4 Improved-Protein Soybeans U.S. • Food industry functionality N/A LOW BRAZIL 3 High-Oil Soybeans U.S. • Food industry functionality ARGENTINA HIGH 3 Omega-3 Soybeans U.S. • Food industry functionality N/A • Improved yield Insect Protected + Roundup MID 3 Brazil ARGENTINA RReady2Yield Soybeans • Improved insect protection LOW BRAZIL 3 Dicamba-Tolerant Soybeans U.S. • Durable weed control ARGENTINA LOW 3 Vistive III Soybeans U.S. • Food industry functionality N/A INDIA MID 2 Bollgard III Cotton U.S. • Improved insect protection AUSTRALIA BRAZIL LOW U.S. 2 Roundup RReady2Yield Canola Canada • Improved yield EU 27 COMMERCIAL VALUE RANGES AT 2020: LOW <$150M MID $150-$300M HIGH $300-$500M MEGA >$1B 26
  • 27. SUMMARY Our Biotech and Breeding Pipeline Is Accelerating, With Progress in Projects and Widening Yield Advantages MILESTONES: Biotech pipeline is accelerating 10 projects either advanced phases or were added to the pipeline – among the most in any annual update Q1 Q4 First time transitioned 4 projects from Phase 2 to Phase 3 Q2 Q3 First multi-generational advancement as 2 generations of corn drought family advance SmartStax enters the pipeline as the platform for corn, complementing Roundup RReady2Yield as the soybean platform ANNUAL R&D CYCLE: SEEDS & TRAITS Breeding programs yields impressive WHAT CHANGED 2007-2008? DEKALB germplasm maintains impressive • 5 projects advanced phases 8.4 bu/ac advantage; gap widens to 14.6 • 5 products were added bu/ac when protected with YieldGard VT • Vistive II was removed in favor of Vistive III Triple stack • “Water-use efficiency” soybeans reclassified as Asgrow germplasm yield advantage “2nd-Gen Higher-yielding soybeans” improves to average 1.27 bu/ac; Roundup • Two former Renessen projects were rolled into the RReady2Yield to provide 7-11% boost Monsanto pipeline 27