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Third Quarter 2007
     Earnings Teleconference




                           October 18, 2007


Valid as of October 18, 2007
Third Quarter 2007
                   Earnings Teleconference

Introduction



                                             Amal Naj
       Senior Vice President, WW Investor Development
                                            & Strategy


              Valid as of October 18, 2007
Forward-Looking Statement and
Non-GAAP Financial Information

  Our discussions during this conference call will include forward-
  looking statements. Actual results could differ materially from
  those projected in the forward-looking statements. The factors
  that could cause actual results to differ are discussed in Pfizer’s
  2006 Annual Report on Form 10-K and in our reports on Form
  10-Q and Form 8-K.

  Also, the discussions during this conference call will include
  certain financial measures that were not prepared in accordance
  with generally accepted accounting principles. Reconciliations of
  those non-GAAP financial measures to the most directly
  comparable GAAP financial measures can be found in Pfizer’s
  Current Report on Form 8-K dated October 18, 2007.

  These reports are available on our website at www.pfizer.com
  in the quot;Investors—SEC Filingsquot; section.
                       Valid as of October 18, 2007
                                                                        3
Third Quarter 2007
               Earnings Teleconference

Opening Remarks




                                         Jeffrey Kindler
                    Chairman & Chief Executive Officer


          Valid as of October 18, 2007
Third Quarter 2007
                 Earnings Teleconference

Financial Review




                                           Frank D’Amelio
        Senior Vice President & Chief Financial Officer


            Valid as of October 18, 2007
Third-Quarter 2007

Income Statement Highlights
 ($ millions, except per-share amounts)
                                                   Third Quarter                                        Year to Date
                                            2007         2006    Change                          2007       2006                     Change
                                          $ 11,990     $ 12,280    (2%)                        $ 35,548   $ 35,768                     (1%)
  Reported Revenues

                                                761             3,362           (77%)              5,420              9,888             (45%)
  Reported Net Income

                                                0.11              0.46          (76%)                0.78               1.35            (42%)
  Reported Diluted EPS

                             (1)
                                              3,963             3,922               1%           11,711             11,935               (2%)
  Adjusted Income

                                    (1)
                                                0.58              0.54              7%               1.68               1.63                  3%
  Adjusted Diluted EPS

  (1)   Adjusted Income and its components and Adjusted Diluted EPS are defined as Reported Net Income and its components and Reported
        Diluted EPS, excluding Purchase Accounting Adjustments, Acquisition-Related Costs, Discontinued Operations, and Certain Significant
        Items.




        Quarter Impacted by Loss of US Exclusivity for 2 Key Products
                      and Charges related to Exubera
                                                     Valid as of October 18, 2007
                                                                                                                                                   6
Third-Quarter 2007

Certain Significant Items
 ($ in millions on a pre-tax basis)

                                                    Third Quarter              Year to Date
                                                   2007      2006            2007       2006
  Cost-Reduction Initiatives                   $     810         $ 427      $ 3,131   $ 1,348
  - Restructuring Charges                            437             245      2,267       801
  - Implementation Costs                             373             182        864       547
  Sanofi-aventis R&D Milestone                        -              -          -        (118)
  Charges related to Exubera                        2,804            -        2,804       -
  Other                                                28            (86)        37      (160)

  Total Certain Significant Items              $ 3,642           $ 341      $ 5,972   $ 1,070



    Charges Related to Exubera and our Cost-Reduction Initiatives
                     Reduced Reported Results
                                      Valid as of October 18, 2007
                                                                                                 7
Third-Quarter 2007

Charges related to Exubera
 ($ in millions)



                   Intangible Assets               $1,105
                   Inventory                           661
                   Fixed Assets                        454
                   Other Exit Costs                    584
                                             $      2,804




        Represents the Charges Related to our Decision to Exit
      Exubera - - Approximately $2.2 Billion Represents Non-Cash
          Charges while $600 Million Represents Future Cash
                            Expenditures
                                  Valid as of October 18, 2007
                                                                   8
Third-Quarter 2007

Adjusted Income(1) Components
                                                              Third Quarter
      ($ millions, except per-share amounts)
                                                       2007        2006           Change
     Revenues(1)                                     $ 11,950    $ 12,280            (3%)
     Cost of Sales(1)                                     1,810           1,887      (4%)
     SI&A Expenses(1)                                     3,638           3,691      (1%)

     R&D Expenses(1)                                      1,730           1,825      (5%)

     Provision for Income Taxes(1)                        1,099           1,182      (7%)

     Adjusted Income(1)                              $ 3,963          $ 3,922         1%

     Adjusted Diluted EPS(1)                         $     0.58       $    0.54       7%
     (1) See Slide 6 for definition.


      Adjusted Diluted EPS(1) Increased 7% as Cost-Reduction
                     Efforts Further Materialize
                                                                                            9
                                       Valid as of October 18, 2007
Third-Quarter 2007

Adjusted Income(1) Components
                                                                      Year to Date
     ($ millions, except per-share amounts)
                                                       2007               2006       Change
     Revenues(1)                                     $ 35,414           $ 35,768        (1%)

     Cost of Sales(1)                                     5,427              5,119       6%

     SI&A Expenses(1)                                    10,688             10,876      (2%)

     R&D Expenses(1)                                      5,384              5,152       5%

     Provision for Income Taxes(1)                        3,271              3,381      (3%)

     Adjusted Income(1)                              $ 11,711           $ 11,935        (2%)


     Adjusted Diluted EPS(1)                         $      1.68        $     1.63       3%
     (1) See Slide 6 for definition.



       Adjusted Diluted EPS(1) Increased 3% as Cost-Reduction
                      Efforts Further Materialize
                                                                                               10
                                       Valid as of October 18, 2007
Third-Quarter 2007

Quarterly Select Product Highlights
                                          WORLDWIDE                         U.S.                     INTERNATIONAL
          ($ in millions)
                                         2007  Change                   2007 Change                   2007  Change
       In-Line Products(1)
                                       $ 3,170               (5%) $ 1,810                (13%) $ 1,360                 9%
       Lipitor
                                           450                 6%     208                   4%     242                 9%
       Viagra
                                           577                 8%     433                   3%     144                23%
       Celebrex
                                           428                 8%     428                   8%     -                  -
       Zyrtec/Zyrtec D
                                           402                 7%     131                   2%     271                10%
       Xalatan/Xalacom
       New Products(2)
                                             241           630%             186          465%              55           *
       Chantix/Champix
                                             465            37%             269           24%             196          59%
       Lyrica
                                             151           140%              60           22%              91         550%
       Sutent
                             (3)
       LOE Products
                                             640           (47%)              48         (92%)            592          2%
       Norvasc
                                             124           (73%)              31         (92%)             93          8%
       Zoloft
       * Calculation not meaningful.
       (1) Represents worldwide revenues for all pharmaceutical products not included in (2) and (3).
       (2) Represents worldwide revenues for all pharmaceutical products launched in the US since 2005.
       (3) Represents worldwide revenues for all pharmaceutical products that lost US exclusivity in 2006 and 2007.

    New and In-Line Products Continue to Perform Well; Lipitor
             Continues to Face Intense Competition
                                                                                                                             11
                                               Valid as of October 18, 2007
Third-Quarter 2007

2007 Financial Guidance
                                                        Previous Guidance                Revised Guidance
   Revenues                                             $47.0 to $48.0 Billion          $47.5 to $48.0 Billion
   Adjusted Cost of Sales (1) (2)                            Approx. 15.0%                 Approx. 15.5%
                                                                                      Decrease of approx. $600
                                                    Decrease of greater than $500
                                                                                      Million versus 2006 on a
                                                  Million versus 2006 on a constant
   Adjusted SI&A Expenses(1)                                                                                 (3)
                                                                       (3)
                                                                                      constant currency basis to
                                                  currency basis to approx. $15.2
                                                                                         approx. $15.1 Billion
                                                               Billion

   Adjusted R&D Expenses(1)                              Approx. $7.5 Billion            Approx. $7.5 Billion
   Reported Diluted EPS                                      $1.30 to $1.41                $1.01 to $1.10
   Adjusted Diluted EPS(1)                                   $2.08 to $2.15                $2.10 to $2.15
   Effective Tax Rate(4)                                          22.0%                        22.0%
   Cash Flows from Operations                           $12.0 to $13.0 Billion          $12.0 to $13.0 Billion
   Lipitor Revenues                                       Flat to 5% Decline              3% to 5% Decline
   (1) See Slide 6 for definition.   (2) As a Percentage of Revenues
                                     (4) On Adjusted Income(1)
   (3) At 2006 Exchange Rates


       Improved the Range on Select Guidance; Improved SI&A;
         Reported Diluted EPS Impacted by Exubera Charges
                                                                                                                   12
                                                   Valid as of October 18, 2007
Third-Quarter 2007

2008 Financial Guidance
                                                     Previous Guidance                         Revised Guidance

   Revenues                                          $46.5 to $48.5 Billion                   $46.5 to $48.5 Billion
                                                    Reduction of at least                    Reduction of at least
                                                   $1.5 to $2.0 Billion from                $1.5 to $2.0 Billion from
   Adjusted Total Costs(4)                                  2006                              2006 on a constant
                                                                                               currency basis(2)

   Reported Diluted EPS                                   $1.75 to $1.93                           $1.75 to $1.93
   Adjusted Diluted EPS(1)                                $2.31 to $2.45                           $2.31 to $2.45
   Effective Tax Rate(3)                                 22.0% to 22.5%                           22.0% to 22.5%
   Cash Flows from Operations                        $18.0 to $19.0 Billion                   $18.0 to $19.0 Billion

                                                                                 (3) On Adjusted Income(1)
   (1) See Slide 6 for definition.          (2) At 2006 Exchange Rates
   (4) Represents primarily the total of Adjusted Cost of Sales (1), Adjusted SI&A expenses (1), and Adjusted R&D expenses (1).


              Total Costs Savings at Constant Exchange Rates(2);
                          Remainder of 2008 Guidance Unchanged
                                                  Valid as of October 18, 2007
                                                                                                                                  13
Third-Quarter 2007

Key Takeaways
         On-Track to Achieve 2007 Revenue & Adjusted Diluted EPS(1)
         Guidance
                Raised Lower End of Range on Revenues and Adjusted
                Diluted EPS(1)
         Reaffirm 2008 Guidance
                Total Cost Reduction Compared to 2006 At Constant
                Exchange Rates(2)
         $2.8 Billion Pre-tax Charges Recorded Related to Exubera ($2.2
         Billion Non-Cash, $600 Million Cash)
         New Products(3) are Performing Well - - Particularly Chantix,
         Lyrica and Sutent
         Executing on our Plan to Reduce Cost Base; More Work to Do
   (1)   See Slide 6 for definition.   (2) See Slide 13 for definition. (3) See Slide 11 for definition.
                                               Valid as of October 18, 2007                                14
Third Quarter 2007
               Earnings Teleconference

Q&A Session




          Valid as of October 18, 2007

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Pfizer Quarterly Corporate Performance - Third Quarter 2007

  • 1. Third Quarter 2007 Earnings Teleconference October 18, 2007 Valid as of October 18, 2007
  • 2. Third Quarter 2007 Earnings Teleconference Introduction Amal Naj Senior Vice President, WW Investor Development & Strategy Valid as of October 18, 2007
  • 3. Forward-Looking Statement and Non-GAAP Financial Information Our discussions during this conference call will include forward- looking statements. Actual results could differ materially from those projected in the forward-looking statements. The factors that could cause actual results to differ are discussed in Pfizer’s 2006 Annual Report on Form 10-K and in our reports on Form 10-Q and Form 8-K. Also, the discussions during this conference call will include certain financial measures that were not prepared in accordance with generally accepted accounting principles. Reconciliations of those non-GAAP financial measures to the most directly comparable GAAP financial measures can be found in Pfizer’s Current Report on Form 8-K dated October 18, 2007. These reports are available on our website at www.pfizer.com in the quot;Investors—SEC Filingsquot; section. Valid as of October 18, 2007 3
  • 4. Third Quarter 2007 Earnings Teleconference Opening Remarks Jeffrey Kindler Chairman & Chief Executive Officer Valid as of October 18, 2007
  • 5. Third Quarter 2007 Earnings Teleconference Financial Review Frank D’Amelio Senior Vice President & Chief Financial Officer Valid as of October 18, 2007
  • 6. Third-Quarter 2007 Income Statement Highlights ($ millions, except per-share amounts) Third Quarter Year to Date 2007 2006 Change 2007 2006 Change $ 11,990 $ 12,280 (2%) $ 35,548 $ 35,768 (1%) Reported Revenues 761 3,362 (77%) 5,420 9,888 (45%) Reported Net Income 0.11 0.46 (76%) 0.78 1.35 (42%) Reported Diluted EPS (1) 3,963 3,922 1% 11,711 11,935 (2%) Adjusted Income (1) 0.58 0.54 7% 1.68 1.63 3% Adjusted Diluted EPS (1) Adjusted Income and its components and Adjusted Diluted EPS are defined as Reported Net Income and its components and Reported Diluted EPS, excluding Purchase Accounting Adjustments, Acquisition-Related Costs, Discontinued Operations, and Certain Significant Items. Quarter Impacted by Loss of US Exclusivity for 2 Key Products and Charges related to Exubera Valid as of October 18, 2007 6
  • 7. Third-Quarter 2007 Certain Significant Items ($ in millions on a pre-tax basis) Third Quarter Year to Date 2007 2006 2007 2006 Cost-Reduction Initiatives $ 810 $ 427 $ 3,131 $ 1,348 - Restructuring Charges 437 245 2,267 801 - Implementation Costs 373 182 864 547 Sanofi-aventis R&D Milestone - - - (118) Charges related to Exubera 2,804 - 2,804 - Other 28 (86) 37 (160) Total Certain Significant Items $ 3,642 $ 341 $ 5,972 $ 1,070 Charges Related to Exubera and our Cost-Reduction Initiatives Reduced Reported Results Valid as of October 18, 2007 7
  • 8. Third-Quarter 2007 Charges related to Exubera ($ in millions) Intangible Assets $1,105 Inventory 661 Fixed Assets 454 Other Exit Costs 584 $ 2,804 Represents the Charges Related to our Decision to Exit Exubera - - Approximately $2.2 Billion Represents Non-Cash Charges while $600 Million Represents Future Cash Expenditures Valid as of October 18, 2007 8
  • 9. Third-Quarter 2007 Adjusted Income(1) Components Third Quarter ($ millions, except per-share amounts) 2007 2006 Change Revenues(1) $ 11,950 $ 12,280 (3%) Cost of Sales(1) 1,810 1,887 (4%) SI&A Expenses(1) 3,638 3,691 (1%) R&D Expenses(1) 1,730 1,825 (5%) Provision for Income Taxes(1) 1,099 1,182 (7%) Adjusted Income(1) $ 3,963 $ 3,922 1% Adjusted Diluted EPS(1) $ 0.58 $ 0.54 7% (1) See Slide 6 for definition. Adjusted Diluted EPS(1) Increased 7% as Cost-Reduction Efforts Further Materialize 9 Valid as of October 18, 2007
  • 10. Third-Quarter 2007 Adjusted Income(1) Components Year to Date ($ millions, except per-share amounts) 2007 2006 Change Revenues(1) $ 35,414 $ 35,768 (1%) Cost of Sales(1) 5,427 5,119 6% SI&A Expenses(1) 10,688 10,876 (2%) R&D Expenses(1) 5,384 5,152 5% Provision for Income Taxes(1) 3,271 3,381 (3%) Adjusted Income(1) $ 11,711 $ 11,935 (2%) Adjusted Diluted EPS(1) $ 1.68 $ 1.63 3% (1) See Slide 6 for definition. Adjusted Diluted EPS(1) Increased 3% as Cost-Reduction Efforts Further Materialize 10 Valid as of October 18, 2007
  • 11. Third-Quarter 2007 Quarterly Select Product Highlights WORLDWIDE U.S. INTERNATIONAL ($ in millions) 2007 Change 2007 Change 2007 Change In-Line Products(1) $ 3,170 (5%) $ 1,810 (13%) $ 1,360 9% Lipitor 450 6% 208 4% 242 9% Viagra 577 8% 433 3% 144 23% Celebrex 428 8% 428 8% - - Zyrtec/Zyrtec D 402 7% 131 2% 271 10% Xalatan/Xalacom New Products(2) 241 630% 186 465% 55 * Chantix/Champix 465 37% 269 24% 196 59% Lyrica 151 140% 60 22% 91 550% Sutent (3) LOE Products 640 (47%) 48 (92%) 592 2% Norvasc 124 (73%) 31 (92%) 93 8% Zoloft * Calculation not meaningful. (1) Represents worldwide revenues for all pharmaceutical products not included in (2) and (3). (2) Represents worldwide revenues for all pharmaceutical products launched in the US since 2005. (3) Represents worldwide revenues for all pharmaceutical products that lost US exclusivity in 2006 and 2007. New and In-Line Products Continue to Perform Well; Lipitor Continues to Face Intense Competition 11 Valid as of October 18, 2007
  • 12. Third-Quarter 2007 2007 Financial Guidance Previous Guidance Revised Guidance Revenues $47.0 to $48.0 Billion $47.5 to $48.0 Billion Adjusted Cost of Sales (1) (2) Approx. 15.0% Approx. 15.5% Decrease of approx. $600 Decrease of greater than $500 Million versus 2006 on a Million versus 2006 on a constant Adjusted SI&A Expenses(1) (3) (3) constant currency basis to currency basis to approx. $15.2 approx. $15.1 Billion Billion Adjusted R&D Expenses(1) Approx. $7.5 Billion Approx. $7.5 Billion Reported Diluted EPS $1.30 to $1.41 $1.01 to $1.10 Adjusted Diluted EPS(1) $2.08 to $2.15 $2.10 to $2.15 Effective Tax Rate(4) 22.0% 22.0% Cash Flows from Operations $12.0 to $13.0 Billion $12.0 to $13.0 Billion Lipitor Revenues Flat to 5% Decline 3% to 5% Decline (1) See Slide 6 for definition. (2) As a Percentage of Revenues (4) On Adjusted Income(1) (3) At 2006 Exchange Rates Improved the Range on Select Guidance; Improved SI&A; Reported Diluted EPS Impacted by Exubera Charges 12 Valid as of October 18, 2007
  • 13. Third-Quarter 2007 2008 Financial Guidance Previous Guidance Revised Guidance Revenues $46.5 to $48.5 Billion $46.5 to $48.5 Billion Reduction of at least Reduction of at least $1.5 to $2.0 Billion from $1.5 to $2.0 Billion from Adjusted Total Costs(4) 2006 2006 on a constant currency basis(2) Reported Diluted EPS $1.75 to $1.93 $1.75 to $1.93 Adjusted Diluted EPS(1) $2.31 to $2.45 $2.31 to $2.45 Effective Tax Rate(3) 22.0% to 22.5% 22.0% to 22.5% Cash Flows from Operations $18.0 to $19.0 Billion $18.0 to $19.0 Billion (3) On Adjusted Income(1) (1) See Slide 6 for definition. (2) At 2006 Exchange Rates (4) Represents primarily the total of Adjusted Cost of Sales (1), Adjusted SI&A expenses (1), and Adjusted R&D expenses (1). Total Costs Savings at Constant Exchange Rates(2); Remainder of 2008 Guidance Unchanged Valid as of October 18, 2007 13
  • 14. Third-Quarter 2007 Key Takeaways On-Track to Achieve 2007 Revenue & Adjusted Diluted EPS(1) Guidance Raised Lower End of Range on Revenues and Adjusted Diluted EPS(1) Reaffirm 2008 Guidance Total Cost Reduction Compared to 2006 At Constant Exchange Rates(2) $2.8 Billion Pre-tax Charges Recorded Related to Exubera ($2.2 Billion Non-Cash, $600 Million Cash) New Products(3) are Performing Well - - Particularly Chantix, Lyrica and Sutent Executing on our Plan to Reduce Cost Base; More Work to Do (1) See Slide 6 for definition. (2) See Slide 13 for definition. (3) See Slide 11 for definition. Valid as of October 18, 2007 14
  • 15. Third Quarter 2007 Earnings Teleconference Q&A Session Valid as of October 18, 2007