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THE COVEXIN 10 STORY WHAT’S SO SPECIAL ABOUT COVEXIN 10?
WHAT’S SO SPECIAL ABOUT COVEXIN 10 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Aluminium Adjuvants ,[object Object],[object Object],[object Object]
How Does PZC Affect an Aluminum Adjuvant PZC pH +
How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended + +
How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended Protein of Interest PZC 5.5 0 + + +
How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended Protein of Interest PZC 7.8 + + +
Aluminum Hydroxide Clostridial Toxoids Clostridial Toxoids Alum Blending Blending Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+
Alum vs. Aluminum Hydroxide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10 ,[object Object],[object Object]
CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos Required potency
CLOSTRIDIAL VACCINE POTENCY
CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos Required potency
CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos New Potency Level
RESULTING RELEASE LEVELS ≥  2.5 U/ml ≥  4.6 U/ml C. septicum ≥  1.0 U/ml ≥  6.6 U/ml C. sordelli ≥  2.5 U/ml ≥  4.9 U/ml C. tetani ≥  3.5 U/ml ≥  6.0 U/ml C. novyi B ≥  10.0 U/ml ≥  11.7 U/ml C. haemolyticum Ph Eur pass Ph Eur pass C. chauvoei ≥  5.0 IU/ml ≥  5.3 IU/ml C. perfringens  D ≥  10.0 IU/ml ≥ 18.2 IU/ml C. perfringens  B & C ≥  0.5 U/ml ≥  0.5 U/ml C. perfringens  A Potency: EU Pharm Release Specification Covexin 10  Release specification Component
HOW DOES THIS HELP?
EU MARKET COMPARISON TRIALS ,[object Object],[object Object]
HOW THE TNT TEST WORKS Serum + Serum Toxin (10 Units) = All toxin neutralized ≥  10 Antitoxin Units Mouse dead ≤  10 Antitoxin Units
How Do We Stack Up Against the Leading Competitor?
How Do We Stack Up Against the Leading Competitor?
How Do We Stack Up Against the Leading Competitor?
How Do We Stack Up Against the Leading Competitor?
How Do We Stack Up Against the Leading Competitor?
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object],[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object],[object Object],[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object],[object Object],[object Object],[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object],[object Object],[object Object],[object Object],[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object]
WHAT’S SO SPECIAL ABOUT COVEXIN 10? ,[object Object],[object Object]
WHY IS COVEXIN 10 BETTER THAN ULTRAVAC, ETC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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2005 4-k o'connell whats special about c10 MSD Finca Productiva Salud Del Hato

  • 1. THE COVEXIN 10 STORY WHAT’S SO SPECIAL ABOUT COVEXIN 10?
  • 2.
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  • 4. How Does PZC Affect an Aluminum Adjuvant PZC pH +
  • 5. How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended + +
  • 6. How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended Protein of Interest PZC 5.5 0 + + +
  • 7. How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended Protein of Interest PZC 7.8 + + +
  • 8. Aluminum Hydroxide Clostridial Toxoids Clostridial Toxoids Alum Blending Blending Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+
  • 9.
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  • 11. CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos Required potency
  • 13. CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos Required potency
  • 14. CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos New Potency Level
  • 15. RESULTING RELEASE LEVELS ≥ 2.5 U/ml ≥ 4.6 U/ml C. septicum ≥ 1.0 U/ml ≥ 6.6 U/ml C. sordelli ≥ 2.5 U/ml ≥ 4.9 U/ml C. tetani ≥ 3.5 U/ml ≥ 6.0 U/ml C. novyi B ≥ 10.0 U/ml ≥ 11.7 U/ml C. haemolyticum Ph Eur pass Ph Eur pass C. chauvoei ≥ 5.0 IU/ml ≥ 5.3 IU/ml C. perfringens D ≥ 10.0 IU/ml ≥ 18.2 IU/ml C. perfringens B & C ≥ 0.5 U/ml ≥ 0.5 U/ml C. perfringens A Potency: EU Pharm Release Specification Covexin 10 Release specification Component
  • 16. HOW DOES THIS HELP?
  • 17.
  • 18. HOW THE TNT TEST WORKS Serum + Serum Toxin (10 Units) = All toxin neutralized ≥ 10 Antitoxin Units Mouse dead ≤ 10 Antitoxin Units
  • 19. How Do We Stack Up Against the Leading Competitor?
  • 20. How Do We Stack Up Against the Leading Competitor?
  • 21. How Do We Stack Up Against the Leading Competitor?
  • 22. How Do We Stack Up Against the Leading Competitor?
  • 23. How Do We Stack Up Against the Leading Competitor?
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