With more than 400,000 patients in the United States suffering from ESRD, and 100,000 more developing permanent kidney failure every year, the disease is exacting a significant toll on patients, their families, and on our health care system.

1. The Kidney Project
NEW HOPE FOR A PERMANENT SOLUTION

2. End Stage Renal Disease (ESRD)
With more than 400,000 patients in the United States suffering from ESRD, and
100,000 more developing permanent kidney failure every year, the disease is
exacting a significant toll on patients, their families, and on our health care
system.
 ESRD is always fatal without treatment
 A kidney transplant from a live or deceased donor is still the best option for
treatment, but donor organs are in extremely short supply
 Dialysis is only a short-term answer; it is costly, hard on the patient physically,
and very restricting
 Patients and their families have long dreamed of a permanent and patient-
friendly solution for the treatment of ESRD that could provide the functional
benefits of a live kidney without the need for a lifetime of expensive
immunosuppressant drug therapy

3. A Solution is in Sight
The Kidney Project
Advances in science and technology over the
decades since the first kidney transplant in 1962
have made it possible to understand the
functioning of the kidney sufficiently to drive
development of an artificial transplant solution.
 The Kidney Project has developed a
compact, implantable, bio-artificial kidney
that is the size of a small coffee cup
 Powered by the patient’s own blood pressure
 No need for external devices or
immunosuppressant drugs

4. Multicenter, Interdisciplinary Team
The Kidney Project is spearheaded by doctors, scientists veterinarians, and
engineers at universities, hospitals and companies throughout the
country.
 William H. Fissell, MD, Vanderbilt Center for Kidney Disease, is the
medical lead
 Shuvo Roy, PhD, University of California, San Francisco, is the technical
lead
 Efforts are being coordinated with the NIH and the U.S. Food and Drug
Administration, with participation in the FDA’s new expedited
regulatory approval process, EAP
 The primary challenge at present is the funding needed to take the
device through clinical trials

5. Timeline
 Clinical Trials to begin in 2017
 First Human Trials anticipated in 2017
 Clinical trials are anticipated to be completed by 2020, at which time the
device would be available to patients for implant
The greatest obstacle will be funding. The Kidney Project has received
almost $7 million from federal agencies in the United States for basic
research and early groundwork. More donations are needed in order to
commercialize the artificial kidney.
Donate NOW
https://makeagift.ucsf.edu/site/SPageServer?pagename=A1_API_AppealGivingFor
m&Primary=Pharmacy&Allocation=Artificial%20Kidney%20Project&AppealCode=
PKW11&AllocationCode=B2915&SchoolCode=PHA

6. Join the “buzz” about artificial
kidney research at
www.kidneybuzz.com
HTTP://WWW.KIDNEYBUZZ.COM/ARTIFICIAL-KIDNEY-HOLDS-PROMISE-FOR-
THOSE-AFFLICTED-WITH-ESRD/2013/4/2/ARTIFICIAL-KIDNEY-HOLDS-PROMISE-
FOR-THOSE-AFFLICTED-WITH-ESRD