Parkinson\'s Disease

Parkinson’s Disease Nature, Nurture, & Neurodegeneration December 9 th , 2008 8am

Parkinson’s disease: Learning Objectives ,[object Object],[object Object],[object Object],[object Object]

Arch Neurol. 2008 Jun;65(6):705-8 . “ The final straw that will break the nosologic back of Parkinson disease is the accumulating genetic evidence.”

Clinical definitions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other “Parkinsonian” Diseases

Pathologic definitions (20 th Century) ,[object Object],[object Object]

The genetic revolution: 12 linked loci, 6 genes cloned ATP13A2 1p AR PARK9 DJ-1 1p AR PARK7 PINK1 1p AR PARK6 Parkin 6q AR PARK2 LRRK2 12q AD PARK8 α synuclein 4q AD PARK1 Protein Locus Inheritance Acronym

The synuclein age ,[object Object],[object Object],[object Object]

Leucine-rich repeat kinase 2 (LRRK2) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Parkin & PINK1-associated PD ,[object Object],[object Object],[object Object],[object Object]

Epidemiology of PD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

When only the DMN-V contains Lewy bodies, synuclein pathology is also found in the anterior olfactory system and the enteric nervous system (including the medulla spinalis )

Mitochondrial dysfunction (Parkin, PINK-1) Environmental oxidative stress with free radical generation Proteosomal dysfunction Cell Death Parkinson’s Disease Inclusion formation

Chapter I. Definition-History-Cases ,[object Object],[object Object],[object Object],[object Object]

Chapter I. Definition-History-Cases ,[object Object],[object Object],[object Object],[object Object],[object Object]

PATHOGNOMONIC SYMPTOMS EXAMINED ,[object Object],[object Object]

Wilhelm von Humboldt (1767-1835) ,[object Object],[object Object]

SUPPOSED PROXIMATE CAUSE ,[object Object]

..but how few can estimate the benefits bestowed on mankind, by the labours of a Morgagni, Hunter, or Baillie. FINIS.

Parkinson\'s Disease

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