The document summarizes the Morita-Baylis-Hillman reaction, which forms carbon-carbon bonds between activated alkenes and electrophiles catalyzed by tertiary amines. It discusses introducing asymmetry, chiral catalysts used, and mechanisms. Examples are given of drugs synthesized using this reaction, including pregabalin and compounds with antiproliferative or antimalarial properties. In conclusion, the reaction enables easy carbon-carbon bond formation and synthesis of biologically active molecules.
2. Pregabalin (Neuropathic pain) Sampatrilat (Vasopeptidase inhibitor) Anti-malarial agents Antiproliferative agent Drugs & biological active molecules synthesized by using Baylis Hillman strategy
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4. “ A carbon-carbon bond is formed between the α -position of activated alkenes such as α,β-unsaturated esters, amides, nitriles, ketones and electron-deficient sp 2 carbon atom of various aldehyde under the catalytic influence of a tertiary bicyclic amine such as DABCO, pyrrocoline (indozoline) or quinuclidine, producing highly functionalized product” Baylis, A.B.; Hillman, M.E.D.; German Patent 2155113, 1972 Chem. Abstr . , 1972 , 77 , 34174q Original patent information 4
5. A plausible mechanistic pathway Basavaiah, D., Rao, A. J., Satyanarayana,T., Chem.Rev ., 2003 , 103 ,811 Michael addition of the nucleophilic catalyst to the activated olefin. Quenching the zwitterionic adduct with an electrophile. Proton transfer and elimination of the catalyst 5
14. Brzeinski, L.J.; Rafel, S.; Leahy, J.W.; J.Am.Chem.Soc. 1997 , 119 , 4317 Chiral Michael acceptors in Asymmetric MBH More stable 14
15. Chiral glyoxylates as electrophiles Bauer, T.; Tarasiuk J.; Tett. Asymm .; 2001 , 12 , 1741 s-cis s-cis s-trans In all case bottom side of reacting formyl group is blocked by phenyl ring. 15
16. Hatakeyama, et al.; Org. Lett., 2003 , 17 , 3103 β -Isocupreidine-catalized reaction of Imines More stable 16
18. N-methylprolinol as chiral base catalyst Krishna, P. R.; Kannan, V.; Reddy P. V. N. Adv. Synth. Catal . 2004 , 346 , 603 More stable 18 (R)
19. Free hydroxy group in the chiral amine plays a major role in chirality induction Tang, H.; Zhao, G.; Zhao, Z.; Geo, P.; He, L.; Tang, C.; Eur. J. Org. Chem. 2008 , 126 Chiral Tertiary Amine/L-Proline as Cocatalyst
20. Shi, Y. L.; Shi, M.; Adv. Synth. Catal .; 2007 , 349 , 2129 Chiral Thiourea-Phosphine Organocatalyst 20
21. Conformational lock in a Brønsted acid–Lewis base organocatalyst The acid–base functionalities help in substrate activation and fixing of the organocatalyst conformation to promote the reaction with high enantioselectivity . Mataui, K., Tanaka, K., Horii, A., Takizawa, S., Sasai, H.; Tett. Asym., 2006 , 17 , 578 1a : (S)-3-[4-(dimethylamino)pyridin-2-yl]BINOL 1b : (S )-3-[4-(dimethylamino)pyridin-3-yl]BINOL 1c : (S)-3-[3-(dimethylamino)pyridin-5-yl]BINOL 2a : (S)-3-(N-methyl-N-3-pyridinylaminomethyl)BINOL 2b : (S )-3-(N-methyl-N-2-pyridinylaminomethyl)BINOL 2c : (S)-3-(N-methyl-N-4-pyridinylaminomethyl)BINOL 21 β Proposed catalytic cycle for the bifunctional organocatalyst- mediated aza-MBH reaction Br Ø nsted acid unit Concept of chiral bifunctional organocatalyst 1a-b, 1c, 2a-c Novel chiral organocatalyst
22. Novel chiral sterically congested phosphane-amide bifunctional Lewis base Guan, X. Y., Jiang, Y.Q., Shi, M.; Eur. J. Org. Chem .; 2008 , 2150 DCM, 0 o C, y: 90%, ee : 80%, S DCM, 20 o C, y: 88% , ee : 73%, S 22
23. Why bi-functional organocatalyst so important ? Amines covalently attached to a protic function several carbon away. Suitable positioning of H-bond donors for selective intramolecular proton transfer of one of the alkoxide diastereomers , not the others. The alkoxide diasteremers that undergoes the fast selective proton-transfer reaction may also be the diastereomers that is preferentially formed, but this is not a prerequisite. Bi-functional catalysts give good selectivites only if no other protic additives. 23
24. Yang, K. S.; Lee, W.D.; Pan, J. F.; Chen, K.; J. Org. Chem. 2003 , 68 , 915 Chiral Lewis Acid-Catalyzed The stereocontrol elements for achieving enantioselective carbon-carbon bond formation depends on the proper choice of metal and chiral ligands. Structures of camphor derived chiral ligand Lewis acid Yb(OTf) 3 La(OTf) 3 Yield(%) 72 75 % ee 17 84 confign S S 24
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26. Polyether dendrimer supported chiral Lewis bases (R)-DPLBs After reaction Liua, Y. H.; Shia, M.; Adv. Synth. Catal . 2008 , 350 , 122 93% ee ( S ) The dendrimer supported chiral phosphine Lewis bases can be easily and Reused. Lewis base (R)-DPLB3
27. Chiral ionic liquids as reaction media Presence of the hydroxyl group on chiral ILs is propitious for the transfer of chirality Pe´got, B.; Vo-Thanh G.; Gori, D.; Loupy, A.; Tett. Lett .; 2004 , 45, 6425 (R)
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29. Robiette, R.; Aggarwal, V. K.; Harvey, J. N.; J. Am. Chem. Soc ., 2007 , 129 , 15513 Mechanism of MBH reaction – based on computational method 29 PhCHO PhCHO Int.1
30. Hindered bases with high p K a Higher the p K a of the conjugate acid of the amine higher the rate of reaction. (leading to increased concentrations of the intermediate ammonium enolate) e.g.; Quinuclidine (highest p K a), DBU. Improvement of reaction rate Important landmarks Hydrogen-bonding additives or solvents help the proton-transfer step. e.g.; MeOH/ t -BuOH/H 2 O Lewis acids with alcohol-based ligands The Lewis acid-alcohol complex results in increased acidity of the OH groups, which promotes proton-transfer events. 30
31. Three functional groups Via the functional group manipulation develop opportunities in organic synthesis Chiral center For asymmetric version offers challenge to develop efficient catalyst Intra-molecular version Offers challenges to design and synthesize novel class of substrates with several combinations of activated olefinic and electrophilic groups thereby leading to develop various cyclic frameworks of synthetic importance X= O, NR Y= Electron withdrawing group Offers challenge to develop novel activated alkenes , electrophiles and catalyst