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Osnove metabolizma Robert Pal
povzetek metabolnih poti v celicah
Figure 25.14 Lipidi OH Proteini glukoza MK glicerol aminokisline piruvat acetil-CoA elektronska transportna veriga Mitohondriji ciklus TKK
Biološke oksidacije – vir energije a) aerobna celica b) kalorimeter
ATP in  NADPH + H +   Univerzalni energetski molekuli:   ATP    NADPH + H + 1.8
Živalska celica
Metaboli zem = presnova ,[object Object],[object Object],[object Object],[object Object],[object Object]
Značilnosti katabolizma in anabolizma Reducirane, energetsko bogate snovi: Proteini Ogljikovi hidr. Maščobe Oksidirane, energetsko revne snovi: CO 2 H 2 O NH 3 Prekurzorji (Predhodniki) Aminokisline Monosaharidi Maščobne  kisline Dušikove baze Biološke  makromolekule Proteini Polisaharidi  Nukleinske kisline Maščobe Katabolizem Oksidativen Eksergon Anabolizem Reduktiven Edergon ATP ATP ATP NADPH NADPH NADPH Kemijska energija Anabolizem Reduktiven Edergon E = h. 
Redo ks-reakcije v m etaboli z m u ,[object Object],[object Object],[object Object]
Shema katabolizma Stopnja I:   Hidroliza Stopnja II: Oksidacije, Druge reakc., Sinteza ATP v glikolizi Stopnja III: Oksidacije, Druge reakc., Oksidativna fosforilacija Makromolekule Proteini Polisaharidi Lipidi Gradniki Aminokisline Glukoza Mašč.kisline glicerol Skupni produkti Ac-S-CoA, Piruvat Majhni končni produkti Gliceraldehid-3-P Urea, NH 3 Piruvat H 2 O CO 2 Acetil-S-CoA Oksidativna fosforilacija C.C.K. ADP ATP ADP ATP NAD + NADH NAD + NADH FAD FADH 2
Zgradba ATP Fosfoanhidridne vezi ATP (Adenozin-5’-trifosfat) 5’ 1’
Fosfogvanidini ,[object Object],[object Object]
Viri ATP
Sklopitev ET in sinteze ATP
Obdobje prilagoditve telesa na stradanje Običajno se telo  prilagodi na stradanje po 3 tednih! Proteini  so (poleg glicerola)  edini dolgoročni vir glukoze! Substrati GLUKONEOGEZE

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Robert Pal Osnove Metabolizma

  • 3. Figure 25.14 Lipidi OH Proteini glukoza MK glicerol aminokisline piruvat acetil-CoA elektronska transportna veriga Mitohondriji ciklus TKK
  • 4. Biološke oksidacije – vir energije a) aerobna celica b) kalorimeter
  • 5. ATP in NADPH + H + Univerzalni energetski molekuli: ATP NADPH + H + 1.8
  • 7.
  • 8. Značilnosti katabolizma in anabolizma Reducirane, energetsko bogate snovi: Proteini Ogljikovi hidr. Maščobe Oksidirane, energetsko revne snovi: CO 2 H 2 O NH 3 Prekurzorji (Predhodniki) Aminokisline Monosaharidi Maščobne kisline Dušikove baze Biološke makromolekule Proteini Polisaharidi Nukleinske kisline Maščobe Katabolizem Oksidativen Eksergon Anabolizem Reduktiven Edergon ATP ATP ATP NADPH NADPH NADPH Kemijska energija Anabolizem Reduktiven Edergon E = h. 
  • 9.
  • 10. Shema katabolizma Stopnja I: Hidroliza Stopnja II: Oksidacije, Druge reakc., Sinteza ATP v glikolizi Stopnja III: Oksidacije, Druge reakc., Oksidativna fosforilacija Makromolekule Proteini Polisaharidi Lipidi Gradniki Aminokisline Glukoza Mašč.kisline glicerol Skupni produkti Ac-S-CoA, Piruvat Majhni končni produkti Gliceraldehid-3-P Urea, NH 3 Piruvat H 2 O CO 2 Acetil-S-CoA Oksidativna fosforilacija C.C.K. ADP ATP ADP ATP NAD + NADH NAD + NADH FAD FADH 2
  • 11. Zgradba ATP Fosfoanhidridne vezi ATP (Adenozin-5’-trifosfat) 5’ 1’
  • 12.
  • 14. Sklopitev ET in sinteze ATP
  • 15. Obdobje prilagoditve telesa na stradanje Običajno se telo prilagodi na stradanje po 3 tednih! Proteini so (poleg glicerola) edini dolgoročni vir glukoze! Substrati GLUKONEOGEZE