3. TBX5 mutant mouse on bottom. Photo: Malcolm Logan

5. TBX dimers bound to DNA.. Muller and Herrmann, Nature (1997) 389:884

9. Moody, Principles of Developmental Genetics, AP Press, 2007.

29. (Upper) Three-dimensional structure of the X. laevis Xbra T-box bound to a 24-nt DNA duplex indicating the location of residues Gly-80 (red) and Arg-237 (yellow) mutated in the missense mutations Gly80Arg, Arg237Gln, and Arg237Trp Basson C. T. et.al. PNAS 1999;96:2919-2924 ©1999 by The National Academy of Sciences

31. Fan, C. et al. J. Biol. Chem. 2003;278:8780-8785 Immunostaining of NIH-3T3 cells expressing human TBX5

32. Kulisz and Simon, Mol Cell Bio (2008) 28:1553

33. Camarata etal. J Cell Bio (2006) 174:339

36. Horton etal. Dev Genes Evol (2008) 218:613

39. Horton etal. Dev Genes Evol (2008) 218:613

43. Published by AAAS E. N. Olson Science 313, 1922 -1927 (2006) Fig. 3. The heart of Drosophila

44. Published by AAAS E. N. Olson Science 313, 1922 -1927 (2006) Fig. 4. Schematic of transcriptional networks involved in mammalian heart development

45. Plageman, T. F. et al. J. Biol. Chem. 2004;279:19026-19034 The T-box binding consensus sequences of the ANF promoter are required for regulation by Tbx5 and Tbx20

46. Moskowitz etal. Cell (2007) 129:1365

47. Chick embryos 4 Day Gestation, in situ hybridization. The cells expressing Tbx5 will form a wing; those expressing Tbx4 will form a leg. Tbx4 and Tbx5 code for related gene regulatory proteins, which are thought to dictate which type of limb develops. H. Ohuchi et al., Development (1998)125:51–60

48. Logan, M. Development 2003;130:6401-6410 (A) Representation of the prospective limb territories in a stage 15 chick embryo

49. Logan, M. Development 2003;130:6401-6410 Representation of the signals required for forelimb initiation and subsequent limb outgrowth in the mouse

50. Rodriguez-Esteban etal, Nature (1999) 398:814

56. Horton etal., Dev Genes Evol (2008) 218:613.

57. Horton etal., Dev Genes Evol (2008) 218:613.

61. Published by AAAS E. N. Olson Science 313, 1922 -1927 (2006) Fig. 2. Simplified structures of different types of hearts, showing schematic diagrams of hearts and directions of blood flow

95. Hasson, P. et al. Development 2007;134:85-92 Model depicting two phases of limb development

96. Published by AAAS E. N. Olson Science 313, 1922 -1927 (2006) Fig. 2. Simplified structures of different types of hearts, showing schematic diagrams of hearts and directions of blood flow

97. Published by AAAS E. N. Olson Science 313, 1922 -1927 (2006) Fig. 2. Simplified structures of different types of hearts, showing schematic diagrams of hearts and directions of blood flow

98. GRN subcircuits used in both Drosophila and sea urchin development Davidson E. H., Levine M. S. PNAS 2008;105:20063-20066 ©2008 by National Academy of Sciences

103. Bruneau, Nature (2008) 451:943

104. Bruneau, Nature (2008) 451:943

105. Bruneau, Nature (2008) 451:943

106. Bruneau, Nature (2008) 451:943