50. Clinical presentation Symptoms include Pyrexia low grade and Chills. Unexpected Falling HCT, slight increase in indirect bili, spherocytes on blood smear Diagnosis New +DAT and new Ab screening test when new blood is ordered Treatment None in the absence of rapid hemolysis Avoid offending Ag in future tranx Delayed Hemolytic Txn Rxn
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56. Pathophysiology Infusion of Immuno-competent Cells (Lymphocyte) ↓ Patient at risk ↓ proliferation of donor T lymphocytes ↓ attack against patient tissue Patho-physiology Transfusion associated Graft Versus-Host Disease(Ta-GVHD)
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68. Transfusion transmitted diseases SEROLOGICAL TESTING HIV - Ag HIV - Ab HBsAg Anti-HCV Malaria Ag Antibodies to Treponema Pallidum(Syphilis)
69. Transfusion transmitted diseases Estimated risk of transfusion transmitted infection Virus and testing standard Window Period (Days) Point estimate of residual risk 'per unit' HIV 1 and 2 antibody only 22 1 in 2,404,000 1 in 7,299,000 HIV antibody + NAT 9 HCV antibody only 66 1 in 330,000 1 in 3,663,000 HCV antibody + NAT 7 HBV 45 1 in 1,339,000