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To find anti-cancer drugs, different cellular modifications can be looked at: cell death effect on proliferating cells either in 2D culture or on spheroids (3D culture), anti-mitotic, anti-migration/invasion, anti-angiogenesis effects… Different assays can be performed to follow these different effects. High content screening is a multi-parametric technology allowing searching for poly-effects drugs.
In this poster, several well known compounds were tested in 3 different assays: cytotoxicity in 2D culture, cytotoxicity in spheroids (3D culture) and scratch assay (also named wound healing). These 3 models were automated in 96-well plates.