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How the
Zebrafish May
Cure Hearing
    Loss
“I’m sorry, your hearing
    loss is permanent.”

     For thousands of
   Americans each year,
 hearing loss that requires
      help for better
communication becomes a
          reality.
The most common hearing loss is
   damage to the inner ear hair
  cells, or cilia, that reside in the
   cochlea. The damage, called
sensorineural hearing loss, can be
caused by many things, including
excessive noise exposure, disease
      processes, exposure to
    medications and due to the
   “accumulation of birthdays.”
Why is sensorineural hearing
       loss permanent?

 Once hair cells die, they cannot
be replaced. They do not regrow
or regenerate. These cells are the
single most important part of the
 mechanical working part of the
               ear.
If the hair cells are
      damaged, the
 information cannot be
    passed on to the
  hearing nerve. When
someone has damaged
or missing hair cells, the
       result will be
permanent hearing loss.
What’s being done about it?

In recent years, a research team
at the University of Washington’s
 Merrill Bloedel Research Center
 has been working on finding a
 way to resolve the problem of
     permanent hearing loss
The most recent research
    involves the zebrafish.
  The zebrafish has hair cells
 running along the sides of its
body that help sense vibrations
         in the water.
The vibrations are converted to
electrical information that is then
sent to the brain. Sound familiar?
 Unlike human hair cells, though,
the hair cells of the zebrafish are
     able to regenerate when
             damaged.
Researchers hope to find out
  how the zebrafish regenerates
    their hair cells and use this
information to develop a way for
 humans to regenerate damaged
       or missing hair cells.
How the Zebrafish May Cure Hearing Loss

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How the Zebrafish May Cure Hearing Loss

  • 1.
  • 3. “I’m sorry, your hearing loss is permanent.” For thousands of Americans each year, hearing loss that requires help for better communication becomes a reality.
  • 4. The most common hearing loss is damage to the inner ear hair cells, or cilia, that reside in the cochlea. The damage, called sensorineural hearing loss, can be caused by many things, including excessive noise exposure, disease processes, exposure to medications and due to the “accumulation of birthdays.”
  • 5. Why is sensorineural hearing loss permanent? Once hair cells die, they cannot be replaced. They do not regrow or regenerate. These cells are the single most important part of the mechanical working part of the ear.
  • 6. If the hair cells are damaged, the information cannot be passed on to the hearing nerve. When someone has damaged or missing hair cells, the result will be permanent hearing loss.
  • 7. What’s being done about it? In recent years, a research team at the University of Washington’s Merrill Bloedel Research Center has been working on finding a way to resolve the problem of permanent hearing loss
  • 8. The most recent research involves the zebrafish. The zebrafish has hair cells running along the sides of its body that help sense vibrations in the water.
  • 9. The vibrations are converted to electrical information that is then sent to the brain. Sound familiar? Unlike human hair cells, though, the hair cells of the zebrafish are able to regenerate when damaged.
  • 10. Researchers hope to find out how the zebrafish regenerates their hair cells and use this information to develop a way for humans to regenerate damaged or missing hair cells.