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Therapeutic systems lecture 5

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Therapeutic systems and novel drug delivery devices can manipulate drug formulation to control drug release characteristics. This allows drugs to be released at predetermined rates and durations to maintain therapeutic drug concentrations and reduce side effects. Some examples of controlled release oral formulations include prolonged release, sustained release, extended release, and membrane-controlled, matrix-controlled, ion-exchange, and spansule systems. These systems aim to provide advantages like reduced dosing frequency and improved patient compliance compared to immediate release formulations.

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THERAPEUTIC SYSTEMS AND NOVEL DRUG DELIVERY DEVICES Prepared by: S. Campbell-Elliott B Pharm., M Pharm Sc
What are these systems/devices? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rationale ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of Modified release oral formulations ,[object Object],[object Object],[object Object],[object Object]
Criteria for selection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Advantages/Disadvantages of Extended/Sustained release Oral preps ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of Oral Delivery Devices (extended/sustained-release) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
OROS Push-Pull System cont’d ,[object Object],[object Object],[object Object]
Types of Oral Delivery Devices cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Membrane-Controlled (Reservoir) ,[object Object],[object Object],[object Object]
Types of Oral Delivery Devices cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Matrix-controlled Device cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Matrix-controlled Device cont’d ,[object Object],[object Object],[object Object]
Types of Oral Delivery Devices cont’d ,[object Object],[object Object],[object Object],[object Object]
Ion-exchange System cont’d ,[object Object],[object Object],[object Object]
Types of Oral Delivery Devices cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Therapeutic systems lecture 5

  • 1. THERAPEUTIC SYSTEMS AND NOVEL DRUG DELIVERY DEVICES Prepared by: S. Campbell-Elliott B Pharm., M Pharm Sc
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