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https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
ALCOHOL MISUSE IN SPECIAL POPULATIONS;
People with Intellectual Disabilities and people
with Traumatic Brain Injury
Christos Kouimtsidis, FRCPsych, MSc, PhD
Consultant Psychiatrist in Addictions, Surrey & Borders Partnership NHS Foundation Trust
Chair of Mental Health Clinical Academic Group, Surrey Health Partners
Honorary Clinical Senior Lecturer Imperial College London
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Conflict
 Executive Director of
 Private Practice at
The London Psychiatry Centre
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Why special populations
 Magnitude of the problem
 Special risks
 Special barriers to access treatment
 People
 Services
 Treatment might require modifications
 Treatment content
 Staff skills
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
People with Intellectual Disabilities
IQ<70
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Why People with Intellectual Disabilities?
 Now live in the community
 Are more likely to be exposed to substances and to consume them
 Are more vulnerable to adverse effect
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Special barriers to access treatment
 History of Paternalism & Restricted Choice
 Extent of problem drinking among people with ID poorly understood and not
addressed
Before when I was in supported care,
the carer said “no, that’s not allowed,
we’re not allowed to come with you, if
you’re having an alcoholic drink”. And
that stopped me, stopped my freedom
of going out.
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Magnitude of the problem
 Any substance misuse: 0.5% to 2.5% (McGillicuddy & Blane, 1999).
 Alcohol misuse by 50% of adults with ID who are
drinkers (Westermeyer et al, 1996)
 Alcohol 17.8% (men), 15.2% (women) (Adult Psychiatric Morbidity
Survey: England, 2014)
 Alcohol in ID NHS service: 22.5% (Pezzoni, Kouimtsidis, 2015).
 Approximately 5% of youths in D&A services have a
degree of ID (Barrett & Paschos, 2006)
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Why such diversity?
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Special risks
 Screening tools used
 People with ID
may have reduced verbal communication skills (Burnip, 2002),
may be more suggestible (Everington & Fuller, 1999).
may try to mask their difficulties in understanding and
communication (Hassiotis at al, 2012).
 Barriers associated with care providers
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Screening tools need to be modified
Need to be administered by trained personnel
Carers support is crucial
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Treatment modifications
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Clinical trials
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
ID psychosocial interventions
People with LD have cognitive deficits that impair
their ability to learn or generalise new learning and
therefore may require interventions to last longer,
to include maintenance sessions and to be
supported to seek help and attend appointments.
A feasibility study of a psychological intervention to address alcohol misuse for people
with mild to moderate learning disabilities living in the community (EBI-LD)
This presentation presents independent research funded by the National Institute for Health Research (NIHR)
under its Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-1111-26022).
The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the
Department of Health.
Team:
Chief Investigator: Dr Christos Kouimtsidis
Prof Angela Hassiotis, University College London
Dr Katrina Scior, Reader in Psychology, UCL
Dr Gianluca Baio, Reader in Medical Statistics, UCL
Ms Rachael Hunter, Senior Research Associate, Health Economics, UCL
Dr Vittoria Pezzoni, Consultant Psychiatrist HPFT
Dr Eileen McNamara, Consultant Psychiatrist HPFT
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
EBI-LD
 A feasibility study (RCT, economic evaluation & qualitative
study)
 Funded by NIHR (RfPB)
 30 months
 Collaboration between 2 NHS trusts & UCL
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Participants
Adults
Mild to moderate ID
Known to ID professionals as possibly having an alcohol problem
Screening
 Full Scale IQ <70 (based on WASI or previous results)
 Alcohol Use Disorder Identification Test (AUDIT) 8-20
 Participant and carer recruited in pairs
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Feasibility study in England
RCT: EBI versus TAU
30 participants (15 each arm)
5 weekly, 40 mins sessions
+ 60 mins at week 8
Assessments: Baseline, 2/12 and 3/12
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Intervention
 Delivered by trained therapist within ID services
 Combination of Motivational Enhancement Therapy (MET-UKATT) & coping
skills training (UK-CBT)
Motivational assessment
Link amount & problems
Coping skills
Healthy life style
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Qualitative study
 7 participants from intervention arm (6 M), aged 39-70 years; 5 completed all
sessions, 1 declined treatment and 1 attended four sessions.
 Identified themes: being part of the research project, having therapy
sessions, impact of therapy on drinking, reasons of dropping out from therapy.
 6 carers (4 paid carers, and 2 family carers) and 1 health professional.
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Lessons learned for future RCT
 Involvement of service users, family and paid carers in the design, and
execution of the research may increase understanding of the problem.
 Induction of researchers to aid recall in the participants
 A carer rated primary/secondary measure of the outcome of interest could
provide an additional perspective.
 Health and social care professionals’ buy-in of the study could augment their
support in identifying potential participants.
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
EBI-LD publications
 Kouimtsidis C, Hassiotis A, Scior K, Hunter R, Baio G, Pezzoni V. 2015. A feasibility study of a
psychological intervention to address alcohol misuse for people with mild to moderate learning
disabilities living in the community (EBI-LD); study protocol for a randomized controlled trial.
Trials DOI: 10.1186/s13063-015-0629-x
 Kouimtsidis C, Bosco A, Scior K, Baio G, Hunter R, Pezzoni V, Mcnamara E, Hassiotis A. 2017. A
feasibility randomised controlled trial of extended brief intervention for alcohol misuse in
adults with mild to moderate intellectual disabilities living in the community. TRIALS,
12;18(1):216. DOI: 10.1186/s13063-017-1953-0
 Kouimtsidis C, Scior K, Baio G, Hunter R, Pezzoni V, Hassiotis A. 2017. Development of a manual
for Extended Brief Intervention for alcohol misuse for adults with mild to moderate intellectual
disabilities living in the community. Journal of Applied Research in Intellectual Disabilities. (DOI:
10.1111/jar.12409
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Kouimtsidis C, Scior K, Hassiotis A. A Manual for Extended Brief Intervention for Alcohol Misuse by People
with Learning Disabilities; http://www.sabp.nhs.uk/research/news-and-events/alcohol-misuse-pld
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
People with Traumatic Brain Injury
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Magnitude of the problem
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Special risks for people with TBI
 43-68% of mild TBI have normal MRI
 Primary BI not adequate to explain subsequent deterioration
 Frontal lobe damage is the most common problem
1/3 of people with post-concussion syndrome (headaches, dizziness,
concentration difficulties, low mood) difficulties persist:
memory loss occurs in up to 80%
impaired attention, judgment, reduced processing speed
depression, anxiety disorders; 2-3x ↑ suicide rate
‘organic personality disorder’; disinhibition, aggression, impulsiveness, lack of
initiative, inappropriateness, poor social judgment
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Special barriers to access treatment
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Link between AUD and TBI
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
AUD pre TBI
43-66% of TBI have prior alcohol abuse/dependence
38-53% of alcohol dependents have TBI history
Consequences
People with AUD ↑ risk of TBI 60% in any year & ↑risk multiple TBIs
TBI compromises the AUD treatment; ↑ risk of disengagement
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Intoxication at the time of TBI
35-50% TBI incidents involve alcohol intoxication
From those
75% intoxicated when TBI have preinjury AUD
Consequences
more severe TBI, medical complications, ↑ neuronal damage
•3x ↑ ITU days
•2.5x ↑ benzodiazepines
•2x ↑ opioids
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
AUD post TBI
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Treatment challenges
 No evidence-based algorithm for treatment
 Cognitive barriers
↓ Attention, judgment, insight, language
↓ Sort term memory, behavioural control
 Interpersonal barriers
 System barriers
 Inpatient AUD programs may exclude TBI
 Physical disabilities, antidepressants, analgesics
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
Summary
 Magnitude of the problem
 Special risks
 Special barriers to access treatment
 Treatment might require modifications
https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine

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DR CHRISTOS KOUIMTSIDIS - ALCOHOL MISUSE IN SPECIAL POPULATIONS: INTELLECTUAL DISABILITIES AND PEOPLE WITH TRAUMATIC BRAIN INJURY.

  • 1. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine ALCOHOL MISUSE IN SPECIAL POPULATIONS; People with Intellectual Disabilities and people with Traumatic Brain Injury Christos Kouimtsidis, FRCPsych, MSc, PhD Consultant Psychiatrist in Addictions, Surrey & Borders Partnership NHS Foundation Trust Chair of Mental Health Clinical Academic Group, Surrey Health Partners Honorary Clinical Senior Lecturer Imperial College London
  • 2. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Conflict  Executive Director of  Private Practice at The London Psychiatry Centre
  • 3. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Why special populations  Magnitude of the problem  Special risks  Special barriers to access treatment  People  Services  Treatment might require modifications  Treatment content  Staff skills
  • 4. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine People with Intellectual Disabilities IQ<70
  • 5. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Why People with Intellectual Disabilities?  Now live in the community  Are more likely to be exposed to substances and to consume them  Are more vulnerable to adverse effect
  • 6. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Special barriers to access treatment  History of Paternalism & Restricted Choice  Extent of problem drinking among people with ID poorly understood and not addressed Before when I was in supported care, the carer said “no, that’s not allowed, we’re not allowed to come with you, if you’re having an alcoholic drink”. And that stopped me, stopped my freedom of going out.
  • 7. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Magnitude of the problem  Any substance misuse: 0.5% to 2.5% (McGillicuddy & Blane, 1999).  Alcohol misuse by 50% of adults with ID who are drinkers (Westermeyer et al, 1996)  Alcohol 17.8% (men), 15.2% (women) (Adult Psychiatric Morbidity Survey: England, 2014)  Alcohol in ID NHS service: 22.5% (Pezzoni, Kouimtsidis, 2015).  Approximately 5% of youths in D&A services have a degree of ID (Barrett & Paschos, 2006)
  • 8. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Why such diversity?
  • 9. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Special risks  Screening tools used  People with ID may have reduced verbal communication skills (Burnip, 2002), may be more suggestible (Everington & Fuller, 1999). may try to mask their difficulties in understanding and communication (Hassiotis at al, 2012).  Barriers associated with care providers
  • 10. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Screening tools need to be modified Need to be administered by trained personnel Carers support is crucial
  • 11. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Treatment modifications
  • 12. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Clinical trials
  • 13. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine ID psychosocial interventions People with LD have cognitive deficits that impair their ability to learn or generalise new learning and therefore may require interventions to last longer, to include maintenance sessions and to be supported to seek help and attend appointments.
  • 14. A feasibility study of a psychological intervention to address alcohol misuse for people with mild to moderate learning disabilities living in the community (EBI-LD) This presentation presents independent research funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-1111-26022). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Team: Chief Investigator: Dr Christos Kouimtsidis Prof Angela Hassiotis, University College London Dr Katrina Scior, Reader in Psychology, UCL Dr Gianluca Baio, Reader in Medical Statistics, UCL Ms Rachael Hunter, Senior Research Associate, Health Economics, UCL Dr Vittoria Pezzoni, Consultant Psychiatrist HPFT Dr Eileen McNamara, Consultant Psychiatrist HPFT
  • 15. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine EBI-LD  A feasibility study (RCT, economic evaluation & qualitative study)  Funded by NIHR (RfPB)  30 months  Collaboration between 2 NHS trusts & UCL
  • 16. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Participants Adults Mild to moderate ID Known to ID professionals as possibly having an alcohol problem Screening  Full Scale IQ <70 (based on WASI or previous results)  Alcohol Use Disorder Identification Test (AUDIT) 8-20  Participant and carer recruited in pairs
  • 17. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Feasibility study in England RCT: EBI versus TAU 30 participants (15 each arm) 5 weekly, 40 mins sessions + 60 mins at week 8 Assessments: Baseline, 2/12 and 3/12
  • 18. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Intervention  Delivered by trained therapist within ID services  Combination of Motivational Enhancement Therapy (MET-UKATT) & coping skills training (UK-CBT) Motivational assessment Link amount & problems Coping skills Healthy life style
  • 19. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Qualitative study  7 participants from intervention arm (6 M), aged 39-70 years; 5 completed all sessions, 1 declined treatment and 1 attended four sessions.  Identified themes: being part of the research project, having therapy sessions, impact of therapy on drinking, reasons of dropping out from therapy.  6 carers (4 paid carers, and 2 family carers) and 1 health professional.
  • 20. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Lessons learned for future RCT  Involvement of service users, family and paid carers in the design, and execution of the research may increase understanding of the problem.  Induction of researchers to aid recall in the participants  A carer rated primary/secondary measure of the outcome of interest could provide an additional perspective.  Health and social care professionals’ buy-in of the study could augment their support in identifying potential participants.
  • 21. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine EBI-LD publications  Kouimtsidis C, Hassiotis A, Scior K, Hunter R, Baio G, Pezzoni V. 2015. A feasibility study of a psychological intervention to address alcohol misuse for people with mild to moderate learning disabilities living in the community (EBI-LD); study protocol for a randomized controlled trial. Trials DOI: 10.1186/s13063-015-0629-x  Kouimtsidis C, Bosco A, Scior K, Baio G, Hunter R, Pezzoni V, Mcnamara E, Hassiotis A. 2017. A feasibility randomised controlled trial of extended brief intervention for alcohol misuse in adults with mild to moderate intellectual disabilities living in the community. TRIALS, 12;18(1):216. DOI: 10.1186/s13063-017-1953-0  Kouimtsidis C, Scior K, Baio G, Hunter R, Pezzoni V, Hassiotis A. 2017. Development of a manual for Extended Brief Intervention for alcohol misuse for adults with mild to moderate intellectual disabilities living in the community. Journal of Applied Research in Intellectual Disabilities. (DOI: 10.1111/jar.12409
  • 22. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Kouimtsidis C, Scior K, Hassiotis A. A Manual for Extended Brief Intervention for Alcohol Misuse by People with Learning Disabilities; http://www.sabp.nhs.uk/research/news-and-events/alcohol-misuse-pld
  • 23. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine People with Traumatic Brain Injury
  • 24. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Magnitude of the problem
  • 25. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Special risks for people with TBI  43-68% of mild TBI have normal MRI  Primary BI not adequate to explain subsequent deterioration  Frontal lobe damage is the most common problem 1/3 of people with post-concussion syndrome (headaches, dizziness, concentration difficulties, low mood) difficulties persist: memory loss occurs in up to 80% impaired attention, judgment, reduced processing speed depression, anxiety disorders; 2-3x ↑ suicide rate ‘organic personality disorder’; disinhibition, aggression, impulsiveness, lack of initiative, inappropriateness, poor social judgment
  • 26. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Special barriers to access treatment
  • 27. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Link between AUD and TBI
  • 28. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine AUD pre TBI 43-66% of TBI have prior alcohol abuse/dependence 38-53% of alcohol dependents have TBI history Consequences People with AUD ↑ risk of TBI 60% in any year & ↑risk multiple TBIs TBI compromises the AUD treatment; ↑ risk of disengagement
  • 29. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Intoxication at the time of TBI 35-50% TBI incidents involve alcohol intoxication From those 75% intoxicated when TBI have preinjury AUD Consequences more severe TBI, medical complications, ↑ neuronal damage •3x ↑ ITU days •2.5x ↑ benzodiazepines •2x ↑ opioids
  • 30. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine AUD post TBI
  • 31. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Treatment challenges  No evidence-based algorithm for treatment  Cognitive barriers ↓ Attention, judgment, insight, language ↓ Sort term memory, behavioural control  Interpersonal barriers  System barriers  Inpatient AUD programs may exclude TBI  Physical disabilities, antidepressants, analgesics
  • 32. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine
  • 33. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine Summary  Magnitude of the problem  Special risks  Special barriers to access treatment  Treatment might require modifications
  • 34. https://gaiahealthcare.co/Trainers, Researchers and Interventionists in Addiction and Mental Health Medicine