This study evaluated the environmental and health impacts of heavy metal accumulation from mineral fertilizer use in Egyptian agricultural soils over time. Samples of fertilizers, soils, and plants from fields under different cultivation periods were analyzed for heavy metals like lead, cadmium, cobalt, and nickel. The results showed higher heavy metal concentrations in soils and plants from fields cultivated for longer periods, with human health risk increasing as indicated by hazard index values over 1. The study concludes that reduced use of fertilizers containing heavy metals is needed to lower pollution levels and health risks from long-term fertilizer applications.