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IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
___________________________________________________________________________________________________
Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 51
NOVEL METHOD OF IMPLEMENTING SPIROMETER USING
ANDROID
Karthikeyan.A1
, Khaleelu Rahman.M2
, Velmurugan.A3
1, 2
UG Scholar, 3
Assistant Professor, Department of Biomedical Engineering, Sri Ramakrishna Engineering College,
Vattamalaipalayam, Coimbatore, Tamilnadu, India
Abstract
This paper identifies a robust approach in the design and development of portable spirometer for modern healthcare. The nature
of lung disorders which can be tested physiologically consists of the conditions such as asthma, chronic bronchitis and
emphysema. These conditions may be related to COPD (Chronic obstructive Pulmonary Disease) which is then identified as the
third leading contributor related to cigarette smoking. The existing spirometer system is that they are very rigid, nonportable and
costly which is considered as a major drawback. The typical spirometer equipment used in the hospitals and laboratories consists
of a mouthpiece interfaced to a PC. The aim of this paper is to design a portable handheld spirometer unit which is used for the
measurement of lung parameters such as PEF (Peak Expiratory Flow), FVC (Forced Vital Capacity), and FEV1 (Forced
Expiratory Volume in first second).The spirometer designed here is a portable unit interfaced along with a wireless Bluetooth
module which communicates to an android enabled device. The graphical representations are transmitted wirelessly which
indicates the physiological conditions related to the lungs are displayed. The Android compatible spirometer is to provide a
portable access for the doctors and health experts to predict pulmonary disorders.
Keywords: Android, Spirometer, COPD, Bluetooth module.
-----------------------------------------------------------------------***-------------------------------------------------------------------
1. INTRODUCTION
The most common and chronic disorder in children,
affecting an estimate of about 6.2 million individuals of age
group 18 is asthma [1]. The diagnosis and improvements in
the field of asthma studies and its factors causing the
disorder has been increased gradually over a span of 15
years. The major role of asthma as a disease is that it causes
lung inflammation due to swelling of the airway duct which
narrows the air into the lung tissues. The symptoms of
asthma are coughing, wheezing, shortness of breath, and
chest tightness. The factor behind these symptoms may be
smoke or may be a genetic disorder. The prolonged
condition of asthma due to negligence, will lead to COPD
(Chronic Obstructive Pulmonary Disease).
COPD condition includes several lung diseases like
emphysema and chronic bronchitis. The impact of COPD is
the obstruction in the airway tract. The flow of air inhaled
and exhaled in the lungs is less than ideal which means that
the oxygen level should be maintained as per the
requirement of the individual. In diseases such as chronic
bronchitis, the lining of the breathing tube gets swollen,
which in turn produces mucus and later is coughed up.
Similarly, in emphysema the walls of alveolar sacs get
broken down. There might be a condition wherein an
individual might have both emphysema and chronic
bronchitis. In fact, there are around 12 million people who
have succumbed to COPD and roughly around 24 million
who may possess and may not be aware of this disease [2].
A typical spirometer consists of various parts like
mouthpiece, sensors, PC for study and display of the
physiology of the lungs. There are various types of
Spirometers available in the market and it majorly depends
on the type of sensors used. The relative and quick test for
the study of lung parameters is supported with the aid of
spirometer and its technique is often referred to as
spirometry. The results from this technique are easy to
access and readily available without much time delay. The
standards for the minimum performance of the spirometer
are based as per the guidelines of the American Thoracic
Society (ATS) and European Respiratory Society (ERS) [3].
The aim of this paper is to reduce the cost of the mouthpiece
here the mouthpiece is customized based on the requirement
of the individual. A typical graphical representation of the
lung capacity is given in the below figure [4].
Fig -1: Graphical representation of waveforms for inhalation
and exhalation in lungs for an individual
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
___________________________________________________________________________________________________
Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 52
2. SPIROMETER ARCHITECTURE
Fig -2: Block Diagram of Android device coupled
Spirometer
The spirometer design is used to measure and study the
physiology of the lungs. Here the patient is allowed to blow
air in and out through the help of a mouthpiece with
maximum effort. The spirometer design consists of a
differential pressure sensor which measures and converts the
pressure change into an electrical signal. These signals are
filtered and processed by the microcontroller. The output
from the microcontroller is then interfaced to an Android©
device for easy access. The data are then studied, diagnosed
and interpreted on the move by the pulmonologist for easier
access.
The components used in this paper are classified into three
sections: A) Design of mouthpiece along with the placement
of the pressure sensor. B) Sensor interface to the
microcontroller unit C) Wireless transmission of the
controller output along with the interpretation of results on
an Android device.
3. SPIROMETER PROTOTYPE AND ITS
FUNCTION
3.1 Design of Mouthpiece
Before understanding the design of mouthpiece, let us
consider the principle and working of a normal spirometer
used in a healthcare facility.Fig.1 provides the details of the
individual’s lung capacity and volumes. The types of
waveforms obtained are very useful in the design of the
mouthpiece. The mouthpiece designed here is used to
calculate Forced Vital Capacity (FVC), Forced Expiratory
Volume in first second (FEV1) and Peak Expiratory Flow
(PEF) rate. Fig.2 represents the model of the mouthpiece
used for the development of the spirometer prototype. The
mouthpiece connector is designed and is made up of a nylon
rod. Further, this nylon rod is inserted onto a PVC
(polyvinyl chloride) pipe. To obtain a maximum respiratory
potential, an individual is asked to inhale and exhale through
the mouthpiece. The total length of the mouthpiece
connector is about 130mm and its total diameter is of 46mm.
The inner concentric hollow tube structure is made with
different diameters. The pressure acting on the small
diameter of about 28mm is sensed by the sensor. The outer
diameter of nylon rod is designed with 32mm to facilitate
connection of disposable mouthpiece. The outer region of
the mouthpiece is connected to a pressure sensor to sense
the respiratory variation.
Fig -3: Design of mouthpiece connector
3.2 Pressure Sensor
A pressure sensor which is connected to the mouthpiece is a
device which measures the changes in the pressure of gases
and liquids. The working of the sensor is in such a way that
the pressure of the liquid or gases causes the device to
generate electrical signals. Previously, a differential pressure
sensor was used [5]. Later, it was noticed that pressure
sensor MPXV7002 satisfied the requirement. This sensor is
a series of piezoresistive transducer in the small outline
package (SOP), which is a state-of-the-art monolithic silicon
pressure sensor. These pressure sensors give a reading
relative to the normal pressure [9].
This sensor provides an accurate, high level analog output
signal that is proportional to the applied pressure. It is also
designed to measure positive and negative pressure. For
reducing the effects of the sensor noise, a low-pass RC filter
with a cut off frequency of 650 Hz is used.
3.3 Mouthpiece Testing
The mouthpiece is connected to a microcontroller along
with the pressure sensor. The output from the
microcontroller is given to the PC to obtain a plot for
various values related to FVC, FEV1 and PEF are indicated
in the Fig.3.The definitions of these parameters are given
below.
1. FVC-The volume of air that can be blown out by an
individual at a maximal speed and effort after a full
inspiration.
2. FEV1-The maximum volume of air that can be
exhaled in a forced way in the first second, after
taking a deep breath.
3. PEF-The maximum air flow that can be forced during
exhalation.
The pressure sensor is mounted at the center of the
mouthpiece connector. The placement of the sensor lies
between the connector and the inlet tube, which senses the
variation in the pressure levels calculated through
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
___________________________________________________________________________________________________
Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 53
kilopascals.The mouthpiece is tested and compared along
with the software provided by the Schiller spirometer unit,
wherein the graphs are plotted with respect to FVC, FEV1,
and PEF. Fig.4 represents the results of the plot obtained
between the prototype and the Schiller’s unit[5].
3.4 Microcontroller
PIC 16F8XX microcontrollers are RISC controllers with
very small instruction set only of 35 instructions. PIC
16F887 is a 40-pin 8-bit CMOS FLASH microcontroller. It
comes with three operating speeds with 4, 8 or 20 MHz
clock input. It has two types of internal memories; one is
program memory and another is data memory [11]. Program
memory is provided by 8K words of FLASH memory and a
data memory has two sources.
3.5 Bluetooth Module
The output from the microcontroller is given serially to a
Bluetooth module HC-05, which wirelessly transmits the
signal to android device. The HC-05 Bluetooth module
supports SPP (Serial Port Protocol)and is designed for
setting up a transparent wireless serial connection.
The serial port of the Bluetooth module is fully qualified
with the latest version(Bluetooth V2.0+EDR Enhanced Data
Rate) with the speed of 3Mbps. The modulation frequency
of a radio transceiver and baseband is around 2.4GHz. The
CSR Bluecore 04-External single chip Bluetooth system is
used along with CMOS technology [7].
4. TABULATION OF LUNG PARAMETERS
The table1 indicates the approximate values for obtaining a
normal set of data for the age group from 18 till 65 years
[8].
5. RESULTS AND ANALYSIS
The most important step in diagnosing abnormality of lung
function in individuals is to define whether they are within
or outside the healthy subjects range. For this purpose, the
observed value of a patient is usually compared to a
reference value obtained from prediction equations derived
from studies on healthy people [10]. There are a few
variables such as age, gender and body size which have an
impact on the lung function of one individual compared to
another. As a person ages, the natural elasticity of the lungs
decreases. This translates into smaller and smaller lung
volumes and capacities as we age. Body size has a
tremendous effect on PFT values. A small man will have a
smaller PFT result than a man of the same age who is much
larger [12].
The graphical representation of the above table is plotted
with respect to volume (Litres) in X axis and flow (Litres
per second) in Y axis. Fig.4 indicates the normal set of
values for the expected spirometer. The plot is obtained by
inputting standard values from the terminal. Similarly, the
plot for the prototype designed is also obtained and is
represented in Fig.5.
1. Expected waveform of spirometer
Fig -4: Normal spirometer values
2. Obtained waveform of the prototype designed
Fig -5: Obtained value in exhalation alone
AGE
( Yrs)
FEV1 FVC FEV1/FVC
18-28
M: 5 to 4.9ltr
F: 3.7-3.4ltr
M: 6.0 to 5.7ltr
F: 4.5 to 4.2ltr
M: 0.8 to 0.85
F: 0.82 to 0.8
29-35
M: 4.8 to 4.3ltr
F: 3.2 to 2.9ltr
M: 5.6 to 5.0ltr
F: 4.2 to 4ltr
M: 0.85 to
0.86
F: 0.76 to 0.73
29-40
M: 4 to 4.4ltr
F: 2.9 to 2.7ltr
M: 4.5 to 4.9ltr
F: 3.9 to 3.5ltr
M: 0.8 to 0.89
F: 0.75 to 0.77
41-45
M: 5.5 to 5.0ltr
F: 2.8 to 2.5ltr
M: 4.3 to 3.7ltr
F: 3.6 to 3.2ltr
M: 1.2 to 1.36
F: 0.77 to 0.78
45-50
M: 4.8 to 4.3ltr
F: 2.6 to 2.3ltr
M: 3.8 to 3.4ltr
F: 3.1 to 2.5ltr
M: 1.2 to 1.26
F: 0.83 to 0.9
50-55
M: 4.3 to 3.6ltr
F: 2.5 to 2ltr
M: 4.4 to 3.8 ltr
F: 3.3 to 3ltr
M: 0.97 to
0.94
F: 0.75 to 0.67
55-60
M: 3.2 to 2.4 ltr
F: 2 to 1.8ltr
M: 3.6 to 2.6ltr
F: 2.6 to 2.3ltr
M: 0.88 to 0.9
F: 0.76 to 0,78
60-65
M:2.1 to 1.8ltr
F: 1.7 to 1.3ltr
M: 2.4 to 2.5ltr
F: 2 to 1.7ltr
M: 0.85 to
0.72
F: 0.85 to 0.76
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
___________________________________________________________________________________________________
Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 54
3. Android plot
Fig -6: The Graphical plot used as a thumbnail in the of
android user interface.
Table -2: Collected data comparison with standard spirometer
6. FUTURE SCOPE
The prototype of spirometer design can further be enhanced
by including more parameters such as Maximal voluntary
ventilation (MVV), Slow Vital Capacity (SVC), Tidal
Volume (TV) related to the lung function. Further, this
prototype can be designed as a portable handheld device
wherein a mouthpiece is connected to a mobile phone, tablet
to interpret the result. This facility in future may help
pulmonologists, nurses and medical practitioners in assisting
and studying various pulmonary disorders. The clinical
history related to various disorders can be developed as a
database, which can be used as an add-on feature of the
android application. The Global Positioning System (GPS)
tracker is integrated onto the android application to provide
the details related to nearest pulmonologist/hospitals/
laboratories for treatment.
Patient details Predicted value MIRspirobank output Our designed spirometer output
Age(y
r)
Ht(c
m)
Wt(k
g)
FV
C
FEV
1
PEF
FEV1/F
VC
FV
C
FEV
1
PEF
FEV1/
FVC
FVC
FEV
1
PEF
FEV1/F
VC
10 34 25 1.83 1.61 4.05 90.3 1.18 0.91 1.42 77.1 1.15 0.83 1.4 72.17
68 167 66 2.86 2.27 7.33 80.2 1.85 1.37 3.51 74.1 1.80 1.29 3.45 71.66
22 173 76 4.30 3.71 9.09 85.7 4.35 3.53 8.42 81.1 4.31 3.40 8.40 78.8
29 173 68 4.31 3.60 9.35 84.4 3.07 1.69 3.70 55 2.8 1.61 3.62 57.5
42 161 39 3.09 2.58 7.67 84.2 0.85 0.63 1.76 74.1 0.78 0.60 1.65 76.9
44 159 61 2.72 2.28 5.96 84.1 2.68 2.21 6.16 82.5 2.53 2.13 5.89 84.18
46 162 70 2.80 2.33 6.05 82.9 2.89 2.21 6.36 76.5 2.82 2.12 6.23 74.9
33 151 52 2.57 2.23 5.84 88.2 2.80 2.40 6.68 85.7 2.72 2.36 6.59 86.76
48 143 52 2.04 1.75 5.07 87.1 2.10 1.60 3.78 76.2 1.95 1.57 3.70 80.51
26 155 67 3.07 2.64 7.67 86.9 2.28 1.95 3.91 85.5 2.23 1.98 3.97 88.78
flow(l/s)
Volume(L)
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
___________________________________________________________________________________________________
Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 55
A separate database which includes age, height, and other
medical information is added. The data for disease
conditions of different pulmonary disorders are created and
maintained for future reference [12]. The transmission
medium used for communication is further enhanced by
using wireless technologies such as Zigbee, WiFi, WiMax.
7. CONCLUSIONS
The presentation of this paper deals with design and
development of a low cost, highly feasible spirometer.The
implementation of this prototype is executed through the
design of a customized mouthpiece. With the help of this
unit, the above mentioned conditions like asthma, COPD
and other respiratory disorders may be diagnosed. This unit
might be used to predict and control the progression of the
above disorders. Finally the comparison between the actual
spirometer and the obtained waveform of the prototype is
plotted. The result of the prototype obtained slightly varies
with the existing spirometer. The data obtained from this
unit helps the pulmonologist and other health experts to
study and analyze the reason behindthe cause for the
obstructive/restrictive disorders.
ACKNOWLEDGEMENTS
The authors would like to acknowledge these individuals Dr.
JaymohanUnnithan, Kovai Respiratory Care and Research
Center for supporting this project. Assistant Professors
S.Sandesh, M.Tech., Department of Bio-medical
Engineering and A.Bharanidharan, M.E., Department of
Computer Science Engineering at Sri Ramakrishna
Engineering College who contributed equally as a team to
this work in partial fulfillment of the requirements.
REFERENCES
[1]. Asthma and its environmental triggers - The National
Allergen Survey,” NIEHS (National Institute of
Environmental Health Sciences), Research Triangle Park,
NC 27709, US Department of Health and Human Services
[2]. Renee Klein“Research article on COPD and asthma,”
300 Hour Yoga Therapy Program, July 2010.
[3]. Debbie Burton, David P.Johns, Maureen
P.Swanney“Spirometer’s users and buyers’ guide ,”
National Asthma Council Australia, Revised 2011, in press.
[4]. R.S.Khandpur, “Handbook of Biomedical
Instrumentation,”2nd ed., Tata McGraw-Hill, 2007.
[5]. Antoinette Bumatay , Remy Chan, Keith Lauher et al,
“Coupled mobile phone platform with peak flow meter
enables real-time lung function assessment,”IEEE sensors
journal, vol. 12, pp.685-691, March 2012
[6]. Schiller website. [Online].
Available:http://www.schiller.ch/Upload/
Spirometry_EN.pdf.
[7]. “HC-05 Datasheet” ITead Studio, Xili Town,
NanshanDist, Shenzhen, China
[8]. Tomasz Gólczewski et al.: A mathematical reason for
FEV1/FVC dependence on age, Respiratory Research 2012,
13:57
[9]. EngineersGarage, Pressure Sensors [Online] 2002.
Available:http://www.engineersgarage.com/articles/pressure
-sensors-types-working (Accessed: 15 February 2014)
[10]. A.N.Aggarwal, Dheeraj Gupta, Digamber Behera and
S.K.Jindal “Applicability of commonly used Caucasian
prediction equations for spirometry interpretation in India,”
Indian J Med Res 122, August 2005, pp 153-164.
[11]. MikroElektronika, PIC Microcontrollers [Online].
Available: http://www.mikroe.com/chapters/view/2/chapter-
1-pic16f887-microcontroller-device-overview/ (Accessed:
20 December 2013)
[12]. Pulmonary Function Testing [Online]. Available:
http://jan.ucc.nau.edu/daa/lecture/pft.htm (Accessed: 18
February 2014)
BIOGRAPHIES
Karthikeyan.A, was born in Tamilnadu,
India. Completed Diploma in Electronics
and Communication Engineering from
Government Polytechnic College,
Coimbatore in 2007 and currently pursuing
under graduate course, B.E. Biomedical Engineering in Sri
Ramakrishna Engineering College, Coimbatore. His area of
interest includes Endoscopy and Ultrasound.
Khaleelu Rahman.M, originally from
Kerala, India. Completed Diploma in
Electronics and Communication
Engineering from Sree Narayanaguru
Polytechnic College, Coimbatore in 2011
and currently pursuing under graduate course, B.E.
Biomedical Engineering in Sri Ramakrishna Engineering
College, Coimbatore. His area of interest includes Medical
instrumentation and Industrial Automation.
Velmurugan.A was born in Tamilnadu,
India. He completed B.E. Electronics and
Communication Engineering from
Maharaja Engineering College, Avinashi
and M.E VLSI from Karpagam University,
Coimbatore in 1999 and 2013 respectively. Presently he is
working as Assistant Professor at Sri Ramakrishna
Engineering College, Coimbatore. His area of specialization
includes VLSI Design, Biomedical Engineering- Radiology,
and Endoscopy.

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Novel method of implementing spirometer using android

  • 1. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 ___________________________________________________________________________________________________ Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 51 NOVEL METHOD OF IMPLEMENTING SPIROMETER USING ANDROID Karthikeyan.A1 , Khaleelu Rahman.M2 , Velmurugan.A3 1, 2 UG Scholar, 3 Assistant Professor, Department of Biomedical Engineering, Sri Ramakrishna Engineering College, Vattamalaipalayam, Coimbatore, Tamilnadu, India Abstract This paper identifies a robust approach in the design and development of portable spirometer for modern healthcare. The nature of lung disorders which can be tested physiologically consists of the conditions such as asthma, chronic bronchitis and emphysema. These conditions may be related to COPD (Chronic obstructive Pulmonary Disease) which is then identified as the third leading contributor related to cigarette smoking. The existing spirometer system is that they are very rigid, nonportable and costly which is considered as a major drawback. The typical spirometer equipment used in the hospitals and laboratories consists of a mouthpiece interfaced to a PC. The aim of this paper is to design a portable handheld spirometer unit which is used for the measurement of lung parameters such as PEF (Peak Expiratory Flow), FVC (Forced Vital Capacity), and FEV1 (Forced Expiratory Volume in first second).The spirometer designed here is a portable unit interfaced along with a wireless Bluetooth module which communicates to an android enabled device. The graphical representations are transmitted wirelessly which indicates the physiological conditions related to the lungs are displayed. The Android compatible spirometer is to provide a portable access for the doctors and health experts to predict pulmonary disorders. Keywords: Android, Spirometer, COPD, Bluetooth module. -----------------------------------------------------------------------***------------------------------------------------------------------- 1. INTRODUCTION The most common and chronic disorder in children, affecting an estimate of about 6.2 million individuals of age group 18 is asthma [1]. The diagnosis and improvements in the field of asthma studies and its factors causing the disorder has been increased gradually over a span of 15 years. The major role of asthma as a disease is that it causes lung inflammation due to swelling of the airway duct which narrows the air into the lung tissues. The symptoms of asthma are coughing, wheezing, shortness of breath, and chest tightness. The factor behind these symptoms may be smoke or may be a genetic disorder. The prolonged condition of asthma due to negligence, will lead to COPD (Chronic Obstructive Pulmonary Disease). COPD condition includes several lung diseases like emphysema and chronic bronchitis. The impact of COPD is the obstruction in the airway tract. The flow of air inhaled and exhaled in the lungs is less than ideal which means that the oxygen level should be maintained as per the requirement of the individual. In diseases such as chronic bronchitis, the lining of the breathing tube gets swollen, which in turn produces mucus and later is coughed up. Similarly, in emphysema the walls of alveolar sacs get broken down. There might be a condition wherein an individual might have both emphysema and chronic bronchitis. In fact, there are around 12 million people who have succumbed to COPD and roughly around 24 million who may possess and may not be aware of this disease [2]. A typical spirometer consists of various parts like mouthpiece, sensors, PC for study and display of the physiology of the lungs. There are various types of Spirometers available in the market and it majorly depends on the type of sensors used. The relative and quick test for the study of lung parameters is supported with the aid of spirometer and its technique is often referred to as spirometry. The results from this technique are easy to access and readily available without much time delay. The standards for the minimum performance of the spirometer are based as per the guidelines of the American Thoracic Society (ATS) and European Respiratory Society (ERS) [3]. The aim of this paper is to reduce the cost of the mouthpiece here the mouthpiece is customized based on the requirement of the individual. A typical graphical representation of the lung capacity is given in the below figure [4]. Fig -1: Graphical representation of waveforms for inhalation and exhalation in lungs for an individual
  • 2. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 ___________________________________________________________________________________________________ Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 52 2. SPIROMETER ARCHITECTURE Fig -2: Block Diagram of Android device coupled Spirometer The spirometer design is used to measure and study the physiology of the lungs. Here the patient is allowed to blow air in and out through the help of a mouthpiece with maximum effort. The spirometer design consists of a differential pressure sensor which measures and converts the pressure change into an electrical signal. These signals are filtered and processed by the microcontroller. The output from the microcontroller is then interfaced to an Android© device for easy access. The data are then studied, diagnosed and interpreted on the move by the pulmonologist for easier access. The components used in this paper are classified into three sections: A) Design of mouthpiece along with the placement of the pressure sensor. B) Sensor interface to the microcontroller unit C) Wireless transmission of the controller output along with the interpretation of results on an Android device. 3. SPIROMETER PROTOTYPE AND ITS FUNCTION 3.1 Design of Mouthpiece Before understanding the design of mouthpiece, let us consider the principle and working of a normal spirometer used in a healthcare facility.Fig.1 provides the details of the individual’s lung capacity and volumes. The types of waveforms obtained are very useful in the design of the mouthpiece. The mouthpiece designed here is used to calculate Forced Vital Capacity (FVC), Forced Expiratory Volume in first second (FEV1) and Peak Expiratory Flow (PEF) rate. Fig.2 represents the model of the mouthpiece used for the development of the spirometer prototype. The mouthpiece connector is designed and is made up of a nylon rod. Further, this nylon rod is inserted onto a PVC (polyvinyl chloride) pipe. To obtain a maximum respiratory potential, an individual is asked to inhale and exhale through the mouthpiece. The total length of the mouthpiece connector is about 130mm and its total diameter is of 46mm. The inner concentric hollow tube structure is made with different diameters. The pressure acting on the small diameter of about 28mm is sensed by the sensor. The outer diameter of nylon rod is designed with 32mm to facilitate connection of disposable mouthpiece. The outer region of the mouthpiece is connected to a pressure sensor to sense the respiratory variation. Fig -3: Design of mouthpiece connector 3.2 Pressure Sensor A pressure sensor which is connected to the mouthpiece is a device which measures the changes in the pressure of gases and liquids. The working of the sensor is in such a way that the pressure of the liquid or gases causes the device to generate electrical signals. Previously, a differential pressure sensor was used [5]. Later, it was noticed that pressure sensor MPXV7002 satisfied the requirement. This sensor is a series of piezoresistive transducer in the small outline package (SOP), which is a state-of-the-art monolithic silicon pressure sensor. These pressure sensors give a reading relative to the normal pressure [9]. This sensor provides an accurate, high level analog output signal that is proportional to the applied pressure. It is also designed to measure positive and negative pressure. For reducing the effects of the sensor noise, a low-pass RC filter with a cut off frequency of 650 Hz is used. 3.3 Mouthpiece Testing The mouthpiece is connected to a microcontroller along with the pressure sensor. The output from the microcontroller is given to the PC to obtain a plot for various values related to FVC, FEV1 and PEF are indicated in the Fig.3.The definitions of these parameters are given below. 1. FVC-The volume of air that can be blown out by an individual at a maximal speed and effort after a full inspiration. 2. FEV1-The maximum volume of air that can be exhaled in a forced way in the first second, after taking a deep breath. 3. PEF-The maximum air flow that can be forced during exhalation. The pressure sensor is mounted at the center of the mouthpiece connector. The placement of the sensor lies between the connector and the inlet tube, which senses the variation in the pressure levels calculated through
  • 3. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 ___________________________________________________________________________________________________ Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 53 kilopascals.The mouthpiece is tested and compared along with the software provided by the Schiller spirometer unit, wherein the graphs are plotted with respect to FVC, FEV1, and PEF. Fig.4 represents the results of the plot obtained between the prototype and the Schiller’s unit[5]. 3.4 Microcontroller PIC 16F8XX microcontrollers are RISC controllers with very small instruction set only of 35 instructions. PIC 16F887 is a 40-pin 8-bit CMOS FLASH microcontroller. It comes with three operating speeds with 4, 8 or 20 MHz clock input. It has two types of internal memories; one is program memory and another is data memory [11]. Program memory is provided by 8K words of FLASH memory and a data memory has two sources. 3.5 Bluetooth Module The output from the microcontroller is given serially to a Bluetooth module HC-05, which wirelessly transmits the signal to android device. The HC-05 Bluetooth module supports SPP (Serial Port Protocol)and is designed for setting up a transparent wireless serial connection. The serial port of the Bluetooth module is fully qualified with the latest version(Bluetooth V2.0+EDR Enhanced Data Rate) with the speed of 3Mbps. The modulation frequency of a radio transceiver and baseband is around 2.4GHz. The CSR Bluecore 04-External single chip Bluetooth system is used along with CMOS technology [7]. 4. TABULATION OF LUNG PARAMETERS The table1 indicates the approximate values for obtaining a normal set of data for the age group from 18 till 65 years [8]. 5. RESULTS AND ANALYSIS The most important step in diagnosing abnormality of lung function in individuals is to define whether they are within or outside the healthy subjects range. For this purpose, the observed value of a patient is usually compared to a reference value obtained from prediction equations derived from studies on healthy people [10]. There are a few variables such as age, gender and body size which have an impact on the lung function of one individual compared to another. As a person ages, the natural elasticity of the lungs decreases. This translates into smaller and smaller lung volumes and capacities as we age. Body size has a tremendous effect on PFT values. A small man will have a smaller PFT result than a man of the same age who is much larger [12]. The graphical representation of the above table is plotted with respect to volume (Litres) in X axis and flow (Litres per second) in Y axis. Fig.4 indicates the normal set of values for the expected spirometer. The plot is obtained by inputting standard values from the terminal. Similarly, the plot for the prototype designed is also obtained and is represented in Fig.5. 1. Expected waveform of spirometer Fig -4: Normal spirometer values 2. Obtained waveform of the prototype designed Fig -5: Obtained value in exhalation alone AGE ( Yrs) FEV1 FVC FEV1/FVC 18-28 M: 5 to 4.9ltr F: 3.7-3.4ltr M: 6.0 to 5.7ltr F: 4.5 to 4.2ltr M: 0.8 to 0.85 F: 0.82 to 0.8 29-35 M: 4.8 to 4.3ltr F: 3.2 to 2.9ltr M: 5.6 to 5.0ltr F: 4.2 to 4ltr M: 0.85 to 0.86 F: 0.76 to 0.73 29-40 M: 4 to 4.4ltr F: 2.9 to 2.7ltr M: 4.5 to 4.9ltr F: 3.9 to 3.5ltr M: 0.8 to 0.89 F: 0.75 to 0.77 41-45 M: 5.5 to 5.0ltr F: 2.8 to 2.5ltr M: 4.3 to 3.7ltr F: 3.6 to 3.2ltr M: 1.2 to 1.36 F: 0.77 to 0.78 45-50 M: 4.8 to 4.3ltr F: 2.6 to 2.3ltr M: 3.8 to 3.4ltr F: 3.1 to 2.5ltr M: 1.2 to 1.26 F: 0.83 to 0.9 50-55 M: 4.3 to 3.6ltr F: 2.5 to 2ltr M: 4.4 to 3.8 ltr F: 3.3 to 3ltr M: 0.97 to 0.94 F: 0.75 to 0.67 55-60 M: 3.2 to 2.4 ltr F: 2 to 1.8ltr M: 3.6 to 2.6ltr F: 2.6 to 2.3ltr M: 0.88 to 0.9 F: 0.76 to 0,78 60-65 M:2.1 to 1.8ltr F: 1.7 to 1.3ltr M: 2.4 to 2.5ltr F: 2 to 1.7ltr M: 0.85 to 0.72 F: 0.85 to 0.76
  • 4. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 ___________________________________________________________________________________________________ Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 54 3. Android plot Fig -6: The Graphical plot used as a thumbnail in the of android user interface. Table -2: Collected data comparison with standard spirometer 6. FUTURE SCOPE The prototype of spirometer design can further be enhanced by including more parameters such as Maximal voluntary ventilation (MVV), Slow Vital Capacity (SVC), Tidal Volume (TV) related to the lung function. Further, this prototype can be designed as a portable handheld device wherein a mouthpiece is connected to a mobile phone, tablet to interpret the result. This facility in future may help pulmonologists, nurses and medical practitioners in assisting and studying various pulmonary disorders. The clinical history related to various disorders can be developed as a database, which can be used as an add-on feature of the android application. The Global Positioning System (GPS) tracker is integrated onto the android application to provide the details related to nearest pulmonologist/hospitals/ laboratories for treatment. Patient details Predicted value MIRspirobank output Our designed spirometer output Age(y r) Ht(c m) Wt(k g) FV C FEV 1 PEF FEV1/F VC FV C FEV 1 PEF FEV1/ FVC FVC FEV 1 PEF FEV1/F VC 10 34 25 1.83 1.61 4.05 90.3 1.18 0.91 1.42 77.1 1.15 0.83 1.4 72.17 68 167 66 2.86 2.27 7.33 80.2 1.85 1.37 3.51 74.1 1.80 1.29 3.45 71.66 22 173 76 4.30 3.71 9.09 85.7 4.35 3.53 8.42 81.1 4.31 3.40 8.40 78.8 29 173 68 4.31 3.60 9.35 84.4 3.07 1.69 3.70 55 2.8 1.61 3.62 57.5 42 161 39 3.09 2.58 7.67 84.2 0.85 0.63 1.76 74.1 0.78 0.60 1.65 76.9 44 159 61 2.72 2.28 5.96 84.1 2.68 2.21 6.16 82.5 2.53 2.13 5.89 84.18 46 162 70 2.80 2.33 6.05 82.9 2.89 2.21 6.36 76.5 2.82 2.12 6.23 74.9 33 151 52 2.57 2.23 5.84 88.2 2.80 2.40 6.68 85.7 2.72 2.36 6.59 86.76 48 143 52 2.04 1.75 5.07 87.1 2.10 1.60 3.78 76.2 1.95 1.57 3.70 80.51 26 155 67 3.07 2.64 7.67 86.9 2.28 1.95 3.91 85.5 2.23 1.98 3.97 88.78 flow(l/s) Volume(L)
  • 5. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 ___________________________________________________________________________________________________ Volume: 03 Issue: 03 | Mar-2014, Available @ http://www.ijret.org 55 A separate database which includes age, height, and other medical information is added. The data for disease conditions of different pulmonary disorders are created and maintained for future reference [12]. The transmission medium used for communication is further enhanced by using wireless technologies such as Zigbee, WiFi, WiMax. 7. CONCLUSIONS The presentation of this paper deals with design and development of a low cost, highly feasible spirometer.The implementation of this prototype is executed through the design of a customized mouthpiece. With the help of this unit, the above mentioned conditions like asthma, COPD and other respiratory disorders may be diagnosed. This unit might be used to predict and control the progression of the above disorders. Finally the comparison between the actual spirometer and the obtained waveform of the prototype is plotted. The result of the prototype obtained slightly varies with the existing spirometer. The data obtained from this unit helps the pulmonologist and other health experts to study and analyze the reason behindthe cause for the obstructive/restrictive disorders. ACKNOWLEDGEMENTS The authors would like to acknowledge these individuals Dr. JaymohanUnnithan, Kovai Respiratory Care and Research Center for supporting this project. Assistant Professors S.Sandesh, M.Tech., Department of Bio-medical Engineering and A.Bharanidharan, M.E., Department of Computer Science Engineering at Sri Ramakrishna Engineering College who contributed equally as a team to this work in partial fulfillment of the requirements. REFERENCES [1]. Asthma and its environmental triggers - The National Allergen Survey,” NIEHS (National Institute of Environmental Health Sciences), Research Triangle Park, NC 27709, US Department of Health and Human Services [2]. Renee Klein“Research article on COPD and asthma,” 300 Hour Yoga Therapy Program, July 2010. [3]. Debbie Burton, David P.Johns, Maureen P.Swanney“Spirometer’s users and buyers’ guide ,” National Asthma Council Australia, Revised 2011, in press. [4]. R.S.Khandpur, “Handbook of Biomedical Instrumentation,”2nd ed., Tata McGraw-Hill, 2007. [5]. Antoinette Bumatay , Remy Chan, Keith Lauher et al, “Coupled mobile phone platform with peak flow meter enables real-time lung function assessment,”IEEE sensors journal, vol. 12, pp.685-691, March 2012 [6]. Schiller website. [Online]. Available:http://www.schiller.ch/Upload/ Spirometry_EN.pdf. [7]. “HC-05 Datasheet” ITead Studio, Xili Town, NanshanDist, Shenzhen, China [8]. Tomasz Gólczewski et al.: A mathematical reason for FEV1/FVC dependence on age, Respiratory Research 2012, 13:57 [9]. EngineersGarage, Pressure Sensors [Online] 2002. Available:http://www.engineersgarage.com/articles/pressure -sensors-types-working (Accessed: 15 February 2014) [10]. A.N.Aggarwal, Dheeraj Gupta, Digamber Behera and S.K.Jindal “Applicability of commonly used Caucasian prediction equations for spirometry interpretation in India,” Indian J Med Res 122, August 2005, pp 153-164. [11]. MikroElektronika, PIC Microcontrollers [Online]. Available: http://www.mikroe.com/chapters/view/2/chapter- 1-pic16f887-microcontroller-device-overview/ (Accessed: 20 December 2013) [12]. Pulmonary Function Testing [Online]. Available: http://jan.ucc.nau.edu/daa/lecture/pft.htm (Accessed: 18 February 2014) BIOGRAPHIES Karthikeyan.A, was born in Tamilnadu, India. Completed Diploma in Electronics and Communication Engineering from Government Polytechnic College, Coimbatore in 2007 and currently pursuing under graduate course, B.E. Biomedical Engineering in Sri Ramakrishna Engineering College, Coimbatore. His area of interest includes Endoscopy and Ultrasound. Khaleelu Rahman.M, originally from Kerala, India. Completed Diploma in Electronics and Communication Engineering from Sree Narayanaguru Polytechnic College, Coimbatore in 2011 and currently pursuing under graduate course, B.E. Biomedical Engineering in Sri Ramakrishna Engineering College, Coimbatore. His area of interest includes Medical instrumentation and Industrial Automation. Velmurugan.A was born in Tamilnadu, India. He completed B.E. Electronics and Communication Engineering from Maharaja Engineering College, Avinashi and M.E VLSI from Karpagam University, Coimbatore in 1999 and 2013 respectively. Presently he is working as Assistant Professor at Sri Ramakrishna Engineering College, Coimbatore. His area of specialization includes VLSI Design, Biomedical Engineering- Radiology, and Endoscopy.