Anti cancer therapy

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Santé & Médecine Technologie

ANTI-CANCER THERAPY MONOCLONAL ANTIBODIES BY: FIROUZEH KAMALI

Conventional Anti-Cancer Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]

HISTORY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Rationale ,[object Object],[object Object],[object Object],[object Object],[object Object]

Patho-physiology of Tumor Tissue ,[object Object],[object Object],[object Object],[object Object]

Genetic Engineering ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Structure of Antibody ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

3 MECHANISMS RESULTING IN APOPTOSIS ,[object Object],[object Object],[object Object]

1. Antigen Cross-Linking ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

2. Activation of death receptors ,[object Object],[object Object],[object Object]

3. Delivery of Cytotoxic Agents ,[object Object],[object Object],[object Object],[object Object]

General Drug Delivery System ,[object Object],[object Object],[object Object]

TOXIN IMMUNOCONJUGATES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Direct attachment of mAb to drug by S-S bonding

Immunoconjugate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other examples of toxin-immunoconjugates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Why are these toxin-immunoconjugates unsuccessful? ,[object Object],[object Object],[object Object],[object Object]

ADEPT ENZYMES (Antibody-directed enzyme pro-drug therapy) ,[object Object],[object Object],[object Object]

Anti-growth factor mAb Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RITUXIMAB (Rituxan) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Toxic effects of Rituximab ,[object Object]

Factors affecting pharmacokinetic parameters ,[object Object],[object Object],[object Object],[object Object]

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