Presentation - Funding for Innovation in Life & Health Sciences

Funding for Innovation
in Life & Health Sciences
Wifi: TitanicGuests
Twitter: @InvestNI
@innovateuk
@KTNUK

Innovation Landscape
Who’s who & What’s what?
Dr Vicky Kell
Director of Innovation, Research & Development

Companies who are innovating are twice as likely to be growing
(ITI Business Monitor)
Companies who invest in innovation demonstrate greater job
growth, employed better qualified people and are more likely to
export (NESTA)
Companies who collaborate on innovation are more productive
than those that do not (OECD)
Investments in innovation are responsible for 2/3 of UK
productivity growth (NESTA)
Importance of Innovation

What is Innovation?
The process that transforms your ideas into
commercial value.
It requires the execution of your ideas which address
specific challenges and achieve significant value
creation for both your business and your customers.

What is R&D?
• Research and Development plays a critical role
in the innovation process
• An investment in technology and future
capabilities which is transformed into new
products, processes, and services

SO INNOVATION AND R&D IS IMPORTANT
HOW IS NORTHERN IRELAND DOING?

Life & Health Sciences Sector in Northern Ireland
Employment 8,400
LHS average salary well above
the private sector median
2% of private sector employment in
NI
2014 Turnover
£950m
80% in Pharma
10% in Medical Devices
10% Health & Wellbeing
LHS Sector accounts for
13% of NI Exports
65% of all LHS revenue is exports
Exports growing at 10% per annum
NI companies exporting to over 140
countries
170 Companies
Research Infrastructure
1000+ researchers in Centres of Excellence
HERD LHS Funding - £175m
16,000 Students studying LHS subjects
4,000 LHS Graduate per annum
Academics
NI Health Services
66,000 employees
Budget - £4.8bn
R&D Spend - £15m
Health

Life & Health Sciences Sector in Northern Ireland
Growth over 3 years
Sector
Turnover
up 24%
Sector
Employment
up 21%
Industry
R&D Spend
up 90%
Sector
Exports
up 19%

Delivering Economic Benefits for Northern Ireland
Government Industry
Health Academia
Invest NI
Other
Government
Departments
HSC
5 Local Trusts
Acute Hospitals
Almac
Randox
Philips
Exploristics
Queen’s
University
Ulster
University
Life &
Health
Science

Innovation Support Ecosystem
EUROPE NATIONAL LOCAL
Horizon
2020/
Enterprise
Europe
Network
EU
Structural
Funds
UKRI
Research
Councils
+
Innovate UK;
KTP, SBRI,
CRD, Catalysts,
Catapults
Government Departments
(DEL / DETI / DHSSPS /
DARD / DCAL)
Invest NI
Local
Authorities
HE / FE
Other
Support
Orgs*
Public
Research
Institutes
BEIS
* Includes InterTradeIreland, NISP, MATRIX, Private Sector etc
Patent Box
R&D Tax
Credits

A bit more about the “players” & support
Innovation Vouchers
Technical Advisory Unit (TAU)
Design
Proof of Concept
KTP (in conjunction with KTN)
Grant for R&D
Competence Centres
Accelerator
NI Business Information
Access to Finance
Business Information Centre
QUB - Research and Enterprise
UU - Northern Ireland Centre for Stratified Medicine
UU - The Intelligent Systems Research Centre
UU - The Nanotechnology and Integrated Bio-Engineering
Centre
HSC Research and Development
North West Regional College
Catalyst Inc
Enterprise Europe Network
Innovate UK

Invest NI’s role
• Delivery body for economic development
• Offering financial, capability development
and advisory solutions.
• 22 international locations across Europe,
Asia-Pac, IMEA and Americas. 5 offices in
Northern Ireland
• Dedicated sector focused Client Teams
• Specialists in a wide range of business
disciplines

Delivering Success
Invest NI Commitment
• Strategic Priority
• Joined up approach
• Build on proven expertise
• Encourage collaboration
• Exploit International links

Innovation
Vouchers
• A voucher is worth up to £5000 and is used by SMEs to allow them to
work with a Knowledge Provider
• Businesses may have a maximum of 3 vouchers for different projects,
but only one voucher at a time
• 4 open calls for applications per year

TAU & TDI support – advice & financial
• Investigating new technologies or processes
• Product & process problem resolution
• Product approvals e.g. VCA; TuV; UL; CE Marking
• Product/process improvement
• Management systems e.g. ISO9001; ISO27001; BRC;
• Intellectual Property e.g. Patents; Trademarks; licensing
agreements

Current Sector R&D Focus
Medical DevicesOncology
Imaging/Pathology
Diagnostics
Diabetes
Clinical Trials
Neurodegenerative
Diseases
Infectious Diseases

Innovation Advisors (New to R&D)
 3 advisors for Grant for R&D;
 Ciaran Mc Cartan
(Health, Life Sciences & Food)
 Richard Pelan
(Engineering/ICT)
 Robin Humphreys
(ICT/General enquiries)

Project Definition
 Help plan and define the project. This can include:
 A scientific and/or technical literature review
 Defining the market opportunity
 Defining the technical objectives and risks
 Defining the costs of the R&D and understanding the financial implications
 Determining the potential benefits
 Funding capped at £30k (£15k for applying to IUK/H2020) of grant and a guidance of 5-10% of main
R&D project costs
 £24 hour labour rates
 First region to get EU Commission approval
 The actual employee(s) labour rate is vouched

Grant for R&D
 Funding for Invest NI clients and potential clients
 Support for technically risky projects
 Ideas must be exploitable
 Support for future work - not retrospective
 Needs match funding
 Support is discretionary - subject to Invest NI decision

Aspects of Successful Applications
Project
 Level of Innovation
 Technical Risk and R&D Challenge
 Potential to create IP
 Exploitation Potential
 Company & Economic Benefit
Company / Applicant
 Management Ability & Staff Expertise
 Additionality
 Viability
 Track Record

Competence Centres
Collaborative, strategic research, led by industry and resourced by qualified
researchers
 Higher-risk, longer-term research with funding typically 5 years
 Stimulate CRD and contribute to the “market focussed technology innovation
communities”
CASE, Connected Health, NIACE (Advanced composites) and Agri-Food

Targeting External Funding
Enterprises that participate in National & EU projects:
 Increase their R&D and innovation capability by tapping into a broader knowledge base
 Gain access to national/international networks
 Faster access to new markets and customers
 Have access to qualified staff
 Increase their reputation and visibility on a national/EU level
 Receive attractive rates of funding - Horizon 2020 – up to 100% direct costs/25% overheads

Innovate UK
Direct UK Government Funding
 Usually Collaborative
 Mix of theme driven and open call opportunities
 Knowledge Transfer Networks
 Generous support rates
 Competitive

Horizon 2020
Biggest EU Research and Innovation programme ever with nearly €80 billion of
funding available over seven years (2014-2020).
Horizon 2020 is the financial instrument implementing the Innovation Union, a
Europe 2020 flagship initiative aimed at securing Europe's global competitiveness
Invest NI is a UK NCP for SMEs and can provide support for applications to the
SME instrument and Fast Track to Innovation

Queen’s University Belfast
Ulster University
Ulster University
Ulster University
Ulster University
Queen’s University Belfast & Ulster University & NISRA
Ulster University

• Aimed at proving the product and/or market.
• Concept Grants: Quarterly call for up to £10k grants to accelerate
product/solution validation and early prototype developments.
• Concept Plus Grants: Bi-annual call for up to £25k grants for
prototype/product refinement and further customer development.
• https://www.techstartni.com/grants
Proof of Concept – Techstart NI

NIBUSINESSINFO.CO.UK - R&D Diagnostic

Northern Ireland Research Success

Today you will
understand your support
options
Use the experts here to
help you continue your
journey!

Aiden Flynn
Exploristics
Grainne McVeigh
Invest NI
How R&D support helped my business

Joel Ferguson
Knowledge Transfer Network

Knowledge Transfer
Partnerships
KTP
Joel Ferguson
Senior KT Adviser (NI)

What are Knowledge Transfer Partnerships?
1. Partner with an academic team
2. Employ a recent graduate
3. Deliver an innovative, strategically important product/process
4. KTP Programme running more than 40 years
5. More than 60 active Partnerships in NI (800+ across UK)
6. NI consistently the UK’s top performing region

More competitive, wealth
creating business
Well developed
‘manager of future’Impact Research,
Teaching, Papers,
Placements etc Transfer &
‘embedding’
of knowledge
Vital Knowledge
Support partnership fully
University/College
Significant Academic Benefit
Support Company, Project and Graduate
Transfer Knowledge and Capability
Business
Deliver Innovative Product/Process
Embed New Capability
Support and Develop Graduate
Associate (Graduate)
Stretch and Develop
Deliver project
Embed New Capability
Company Based Project
Innovative
Strategically Important
Company Missing Vital Knowledge
Knowledge Not Widely Available
Challenge and Reward for All 3 Partners
KTP Essential Features
More competitive, wealth
creating business
Support partnerships fully
Impact research teaching,
papers, placements etc
Vital knowledge
Transfer and
‘embedding’ of knowledge
Well developed manager of the
future

KTP Features
1. Projects can be 12 to 36-months in duration, typically 24 to 36-months
2. Academic team provide knowledge, expertise and facilities
3. Academic input, typically 0.5 days per week
4. Graduate and project based in company
5. More than 60% of graduates are retained by companies

James Leckey Design Limited: Design and manufacture a range
of support devices for disabled children.
Project One: To embed the skills and knowledge necessary to
successfully integrate existing and emerging technologies into new
Leckey products and understand how data gathered can be used to
provide evidence for clinical practice within paediatrics.
Project Two: To develop an application of motivational learning
design methodologies to enhance and support customers in using
products for home therapy.
Case Study

iHelpr
The Knowledge Transfer Partnership between Inspire Workplaces and Ulster University has lead to
the development of iHelpr.
The iHelpr chatbot is embedded into a web based support hub. The user is guided through validated self-
assessments on topics such as stress, sleep and anxiety. Depending on the users score, they are directed
to the most appropriate self help resource within the support hub or towards face to face services, such as
counselling services or seeing their GP.
Case Study
Inspire Workplaces: A social enterprise that supports mental health in the workplace.

Total Cost
1. Graduate Salary (Pay £18-36k pa) £27 - £45k
2. Graduate Development, Travel, Equipment £6k
3. Access to university expertise and facilities £33k
Total Package worth £66 - £84k
SME 67% Grant Support, Cost to Company £22 - £28k
Large Company 50% Grant Support, Cost to Company £33 - £42k
Jointly funded by Invest NI & Innovate UK
Typical Costs Per Year

Eligibility Summary
1. Ideally 4 employees or more
2. An innovative new product, service or process
3. A strong case for impact on net profit
4. A need to embed a new capability from an academic team
5. Challenging and rewarding project for the company, the associate and the academic
6. Local Advisers to help guide you through the process

Joel Ferguson
Senior KT Adviser (NI), KTN
joel.ferguson@ktn-uk.org
07739 338 681
Nicola Doherty
KTP Programme Manager, Invest NI,
Nicola.Doherty@investni.com
07771 387 607
Ken Frame
KT Adviser (NI), KTN
Ken.frame@ktn-uk.org
07860 863 639
Stephen McComb
KT Adviser (NI), KTN
Stephen.mccomb@ktn-uk.org
07548 128 426
https://ktn-uk.co.uk/programmes/knowledge-transfer-partnerships

Lorraine Acheson & Gordon Ford
Innovate UK

Innovate UK: Funding and connecting
business innovation across the UK
Lorraine Acheson and Gordon Ford
23 October 2018

Innovate UK
Is the UK’s innovation agency.
Our mission is to accelerate UK economic growth
through funding and connecting
business-led innovation
throughout the UK
KNOWLEDGE ECONOMY SOCIETY

£6bn
£0.5bn
UK Research & Innovation - From April 2018

Innovate UK regional presence
across the UK, working to:
 strengthen relationships
 connect Innovate UK family with
regional stakeholders
 ensure a coherent strategy across
the UK
 https://datavis.innovateuk.gov.uk/app/
N. Ireland
Scotland
East Midlands
East of England
South East
North West
West Midlands
Wales
South West
North East,
Yorkshire &
Humber

Variety of health and life science
funding
Biomedical Catalyst
UK-China AMR
£10M
Innovation Loans
Precision Medicine
Investment Accelerator
Genomics Manufacturing
Readiness
£5M
Shaping the Future of
Precision Medicine (CR&D)
£5M
Digital Health
Technologies Catalyst
ISCF challenges
OPEN Grant funding
Asthma UK/Innovate UK
Early Diagnosis

Industrial Strategy and the
Industrial Strategy Challenge Fund (ISCF)

Industrial Strategy Grand Challenges
AI and Data
Economy
Ageing
Society
Clean
Growth
Future of
Mobility

Leading-Edge Healthcare / Medicines
manufacturing technologies
Batteries for clean and flexible energy storage
Robots for a safer world
Self-driving vehicles
Manufacturing and materials of the future
Satellites and space technology
ISCF Challenges – Wave 1 (£683M)

Leading-Edge Healthcare / Medicines
manufacturing technologies
ISCF Challenges – Wave 1 (£683M)
Medicines Manufacturing
Collaborative R&D
£25m
Advanced Therapies
Treatment Centres
£30m
Cell & Gene Therapy
Manufacturing Centre
£12m
Medicines Manufacturing
Innovation Centre
£13m
Vaccines Development
& Manufacturing Centre
£66m
£181m to develop first-of-a-kind technologies for the manufacture of
medicines to accelerate patient access to new drugs and treatments
Digital Health
Technology Catalyst
£35m
Viral vector production
for cell and gene
therapies
£5.6m

£35m
over 4 years
Digital Health
Technology Catalyst
Funded through the Industrial Strategy Challenge Fund
National Information Board.
- address specific market failures so that the digital health sector can grow
- deliver transformative, cost-effective technologies to patients more quickly
Digital Health Technology Catalyst
Round 3 closes 31st October 2018

Digital Health Technology Catalyst, Round 3
Closes 31st October 2018
The aim of this competition is to speed up the development of new
digital solutions to healthcare challenges and grow the industry.
Projects must focus on the feasibility or development of digital health or
digitally-enabled medical technologies. These MUST have the potential
to achieve one or more of the following:
• improve patient outcomes
• transform healthcare delivery
• enable more efficient delivery of healthcare
These technologies may be designed to be used in both clinical or non-
clinical everyday settings.
Projects must be innovative and clearly demonstrate how they will
address needs of the healthcare system.

Overview of the DHTC Round 3 Competition
All DHTC projects must begin by April 1st
2019
Programme
Competitions
Total Funding available
DHTC 3
Feasibility:
Market and/or technical
feasibility
Collaborative R&D:
Industrial research and
experimental development
Up to £1 million Up to £8 million
Total Project Costs £50k - £75k Up to £1 million
Project Duration Up to 12 months
SME led, Collaborative*Project Type
SME led, Single or
collaborative
12 to 24 months
*2 grant claiming organisations
Digital Health Technology Catalyst, Round 3
Closes 31st October 2018

Data to early diagnosis &
precision medicine
Healthy ageing
Next generation services
Audience of the future Quantum technology
Transforming
construction
Transforming food
production
Energy revolution
Second Wave of Challenges

CHALLENGE:
Combine the wealth of
data available with real
world evidence
• Genomics: WGS of
500,000 UK Biobank
Samples
• Digital innovation
Hubs: Link NHS to R&D
data and provide new
analytic tools for business
• Digital Pathology:
Radiology & AI Centres of
Excellence
Data to Early Diagnosis and Precision Medicine
(£210m)
Create new products and services that will
diagnose diseases earlier and help clinicians
choose the best treatment for individual patients.

Healthy Ageing
The challenge is to develop new
products and services that offer
choice, meet their aspirations
and through better, more
effective care, support an
independent lifestyle as they
age. By working together, the
government and industry can
address the challenges of ageing
whilst capturing a growing global
market.

NEW: Innovate UK Biomedical Catalyst GOV.UK webpage:
www.gov.uk/guidance/biomedical-catalyst-what-it-is-and-how-to-apply-for-funding

OPEN Programme
Open grant funding competition Round 3
Scope: “Game changing or disruptive innovation”
Must have the potential for their idea or concept leading to significant return on investment
(ROI), positive economic impact, growth and scale-up of the business
Opens 24th September
Closes 14th November
£20 Million is available
Projects lasting 6-18 months with total costs of £25,000 - £500,000
Projects lasting 19-36 months £25,000 - £2M

Open Competition Innovation Loans
Current round closes 21st November
Affordable, flexible and patient

Terry O’Neill

The Future
Terry O’Neill
Head of Health, KTN

Agenda
1. KTN
2. Example of High Impact Intervention in Health
3. Future Developments
4. Collaboration is complicated
5. Questions
Ktn-uk.org @KTNUK

Knowledge Transfer Network (KTN)
Ktn-uk.org @KTNUK

UK Research and Innovation Ecosystem
(one part of the ecosystem)
Academic Health Science Networks
Dept for Business, Energy and Industrial Strategy
Dept of Health
MedTech and In Vitro Diagnostics Co-operatives
National Institute for Health Research
NHS England
Office for Life Sciences
BEIS OLS DoH
UK Research
& Innovation
KTNInnovate UK
Research Councils
NHS (E, S, W, NI) NIHR
AHSNs MICs
NHS E
Ktn-uk.org @KTNUK

Innovate UK ‘Connect’
Thematic Focus
Knowledge Transfer Advisors
Local Presence
Global Connections
Ktn-uk.org @KTNUK

KTN’s Mission
(Who we are & why we exist)
KTN is the UK’s innovation
network.
Our mission is to deliver economic
growth. We connect people to
speed up innovation, solve
problems and find markets for
new ideas.
We bring together businesses,
entrepreneurs, academics and
funders to develop new products,
processes and services.
UK Economic
Growth
Businesses,
Entrepreneurs
and Investors
KTN The UK’s
Innovation
Network
Technologies,
Inventions and
Creativity
Ktn-uk.org @KTNUK

KTN Objectives
• Increase business led R&D
• Facilitate exploitation of R&D to capture more UK value from
innovation
• Increase collaboration between businesses (B2B) & between
businesses and the research base (B2R) for UK benefit
• Be the strategic partner of choice for innovation networking
• Provide breadth and depth of expertise for businesses
looking to innovate
Ktn-uk.org @KTNUK

Breadth of expertise
Chemistry & IB
Materials
Agri-Food
Health
Manufacturing
European &
International
Diversity
Design & Innovation
Access to Funding &
Finance
KT Advisers
Communications
Events
Finance and Ops
Emerging Tech
Enabling Tech
Creative & Digital
Infrastructure
Transport
Complex Systems

• Discovery and development
• Scale-up and manufactureMedicines
• In vitro technologies (including wearables)
• Implantable technologiesMed Tech
• Systems for diagnosis/remediation of disease
• Electronic records in health & careDigital
KTN Health Priorities
Ktn-uk.org @KTNUK

KTN Fit: Enabling “the World’s most
innovative economy”*
“…do more to address some of the frictions in the
system to support collaboration and the flow of
knowledge between research base and industry,
accelerating the path to market.”
*Industrial Strategy White Paper 2017

Example of High Impact
Interventions in Health
Ktn-uk.org @KTNUK

Prevention
of Disease
Identification
of Disease
Treatment of
Disease
Public
Health
Vaccination
Health
Monitoring
Non-
specific
Chronic Disease
Acute
Disease
Medical
Technology
Lifestyle
change/Wellness –
often Digital
Medicines
What is Health
Ktn-uk.org @KTNUK

Cervical Screening and Vaccination
0
http://www.ncin.org.uk/publications/data_briefings/cervical_incidence_and_screening
CIN I CIN II CIN III Cervical CancerNormal
Biomarker
PAP smear test Diagnostic test
Treatments Intervention
Ktn-uk.org @KTNUK

0
http://www.ncin.org.uk/publications/data_briefings/cervical_incidence_and_screening
16.24,132
16.2
2,620
9.3
2,369
8.3
1988 20081998
Vaccination
• 187m doses worldwide
• 130 countries
• 90% reduction in HPV infections
• 45% reduction on low grade
cytology
• 85% reduction in high grade
cytology
Eradication of HPV associated
cancers by between 2040
and 2050
Ktn-uk.org @KTNUK

Prevention
of Disease
Identification
of Disease
Treatment of
Disease
Developments
Changes to screening process
Changes to vaccine formulation
HPV typing
Focus on high risk age-groups
Novel ablative
Advanced Therapeutics
Ktn-uk.org @KTNUK

Prevention
of Disease
Identification
of Disease
Treatment of
Disease
Future of Health
Driven by ISCF
Whole Genome Sequencing
Longitudinal Cohort Studies
Multi ‘omics
New Diagnostic Tests
Cancer Immunotherapy
Advanced Therapeutics
Ktn-uk.org @KTNUK

It’s Complicated
Ktn-uk.org @KTNUK

Innovate UK
(UKRI)
KTN
International National Regional
OLS
DH
NIHR
MICs
RCs
Trade Assoc.
NICE
Research
Charities
CompaniesCompaniesCompanies
AHSNs
Medilinks
One Nucleus
BioNow
OBN
BioCity
Universities
Hospitals
Academics
Clinicians
European
Commission
FCO-SIN
European
Networks (EBN)
FDA
DIT - Healthcare U
K
LEPs
MHRA
EEN
EEN
Ktn-uk.org @KTNUK

Collaboration using
Public Sector Funding
Ktn-uk.org @KTNUK

Integration Zone
IUK – Industrial Strategy Challenge Fund
IIIa. Product IVa. MarketI. Concept II. Seed IIIb. IVb.
Innovation Funding
Integrated Public / Private Funding Strategy – Health Focus
1
2
3
4
5
6
7
8
9
H2020
Excellence in
Science
Societal Challenges
AI & Data Economy
Healthy Ageing
Clean Growth
Future of Mobility
Open Programme
Regional Growth Fund
Scotland Smart & R&D
HTCs
HICF
I4I
Resp.
Mode
Research
Case Awards Managed Programmes
IKCs
Industrial CASE
Awards
FFF
Day Job Angels VC
Early-stage VC
Family OfficesCRG
Companies
BanksLeadership in KEITS
UKRI
Ktn-uk.org @KTNUK

Commit to reach 2.4% of GDP
investment in R&D by 2027
Industrial Strategy Challenge Fund
Ktn-uk.org @KTNUK

Industrial Strategy Challenge Fund
AI and Data
Economy
Healthy
ageing
Clean
growth
Future of
mobility
Ktn-uk.org @KTNUK

UK Innovation Mapping
Smart Specialisation Hub KTN Landscape Maps
Ktn-uk.org @KTNUK

Develop specific
interventions for diverse
markets
Foster a collaborative
approach wherever
appropriate
Establish and maintain the
UK as the best place to
drive health innovation
Understand
the innovation
landscape
Companies
SMEs
Large
Companies
Stakeholders
Numerous
Ktn-uk.org @KTNUK

Questions?
Terry O'Neill
Head of Health
terry.oneill@ktn-uk.org • 07972 848109
Ktn-uk.org @KTNUK

Relevance to Your Business
You heard about what the future holds – now let’s turn to your
business
What do the future trends mean to you?

•Will your current product/service deliver your
customer needs?
• What modifications would be beneficial?
• What are the economic/social benefits of your product/service
suite?

•Who will your customers be and how will you
engage with them?

•Who will your competitors be?
• What do you know about them and their future-proofing?

•Do you have the partners you need or will you
need new partners?
• Who will they be?
• Will your funding sources change?

Panel Discussion
Ryan Williams, Connected Health
Dave Ribeiro, ProAxis
Dr Mary Jo Kurth, Randox

Presentation - Funding for Innovation in Life & Health Sciences

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