My recent publication

1. Laser Management of Resistant Oral Ulcers in Patients with
Behçet's Disease: A Pilot Study.
P3-2-063 Samir H. Assaad-Khalil 1; Islam M. Kassem2
Department of Internal Medicine 1, Faculty of Medicine &
Department of Cranio-maxillary-facial Surgery 2, Faculty of Dentistry,
Alexandria University, Alexandria, EGYPT.
BACKGROUND PATIENT # 1 RESULTS (Cont.)
Figure (2): Frequency of Diabetic Complications in Type
Behçet’s disease is a chronic 2 Diabetic Patients
inflammatory disorder affecting 50%
multiple systems and may have 45%
46%
serious implications on patients’
quality of life. In fact, resistant oral 40%
ulcers can jeopardize normal life 35%
style. 31.80%
30%
25%
OBJECTIVE Preoperative lesion Infiltration of local anesthesia
20%
18.30%
15.90%
The aim of the present study 15%
has been to assess the efficacy 10%
9.70%
and safety of the use of Carbon
dioxide laser in management of
5%
3.10%
resistant intraoral ulcers in 0%
patients with Behçet’s Disease
Subjects Table IX: Relative Frequency of the Cause of
Hospitalization Due to Diabetic Complications During
the Last 3 Months in Type 2 Diabetic Patients*
The present study included 15 Lesion after application of CO2 laser After one week
patients (10 males 5 females) with
Behçet’s disease, diagnosed
according to the International
Classification Criteria, suffering Size Pre op Post op Time of
from recurrent resistant oral
Patient Age Gender Site Number of ulcers mm pain pain surgery Reccurence
1 32 M Cheek Single 20 5 2 15 no
ulcerations and dysphagia failing 2 52 M Lower lip Single 25 4 1 10 no
to respond to conventional medical 3 25 F Tongue Single 15 4 2 12 yes
therapy.
4 33 F Tongue Multiple 20 5 1 19 no
5 43 M Cheek Single 30 4 1 31 no
6 40 M Tongue Single 45 5 1 10 no
Four patients showed multiple
Alveolar
7 46 M mucosa Single 35 4 1 13 no
ulcers, the rest single ulcer. The 8
9
60
52
M
M
Lower lip
Cheek
Single
Multiple
25
30
4
5
2
3
11
15
no
no
sites of the ulcers were variable
After 3 months After 6 months
10 38 F Tongue Single 45 4 2 8 no
including cheeks, alveolar mucosa,
Alveolar
11 56 M mucosa Single 25 4 1 8 no
tongue, and lips. The ulcers size 12
13
45
39
M
F
Cheek
Lower lip
Multiple
Multiple
30
45
5
5
2
1
7
6
no
no
varied from 15 to 45 mm2.
PATIENT # 2
14 62 M Cheek Single 40 4 3 7 yes
15 29 F Cheek Single 30 3 1 9 no
Methods
Carbon dioxide laser has been
used to vaporize the ulcers with
caution to avoid bleeding. All
patients were followed up to CONCLUSION
CONCLUSION
evaluate the efficacy and safety of
the used intervention. This pilot intervention study
Preoperative cheek lesions Preoperative throat lesions suggests that Carbon dioxide laser
This included the impact on technique can be considered as an
pain, effect on healing, effect on effective and safe therapeutic
recurrence and on the quality of modality for the management of
life (The SF-36 QoL Scale and the resistant oral ulcers particularly
Washington QoL in Oral Cancer). associated with dysphagia and
pain in patients with Behçet’s
RESULTS
disease.
A significant improvement of all CONTACT INFORMATIONS
studied parameters has been
observed. A 50% improvement in
Prof. Samir Helmy ASSAAD-KHALIL
both the pain score and QoL Address: Department of Internal Medicine,
Scales. Only 2 patients out of 15 Post operative cheek lesions Post operative throat lesions Faculty of Medicine, Alexandria University,
Alexandria, EGYPT.
showed recurrence during a six Phone: +20-1222197789
months follow up period. Fax: +203-4833321
Email: assaadkhalil@hotmail.com
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