Racecadotril

Racecadotril Race to Control Mortality and Morbidity in Diarrhoea

Defining - Diarrhoea / Dysentery ,[object Object],[object Object],[object Object],[object Object]

Defining – Intestine / Villi

Causes of Diarrhoea Viral infections Bacterial infections most cases of diarrhea, typically with mild-to-moderate symptoms and frequent, watery bowel movements, abdominal cramps, and low-grade fevers. cause the more serious cases of diarrhea Causes of Diarrhoea Gastro-enteritis is diarrhoea caused by bacteria

Diarrhoea - Current Strategies ,[object Object],[object Object],[object Object],[object Object]

Preventive Measures of Diarrhoea ,[object Object],[object Object],[object Object],[object Object]

Oral Rehydration Therapy ,[object Object],[object Object]

Nutritional Therapy ,[object Object],[object Object],[object Object]

Nutritional Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]

Drug Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Commonly Used Drug Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]

HIV Associated Diarrhoea pathogen- specific therapy General treatment to relieve symptoms HAART- Highly active antiretroviral therapy 3 forms of Treatment option

Newer Strategies ,[object Object],[object Object],[object Object]

Racecadotril: What Is It? ,[object Object],[object Object]

Study Details ,[object Object],N Engl J Med 2000;343:463-7.

Dose In Study ,[object Object],N Engl J Med 2000;343:463-7.

Stool Output ,[object Object],N Engl J Med 2000;343:463-7.

Duration of Diarrhoea ,[object Object],N Engl J Med 2000;343:463-7.

Intake of ORT ,[object Object],N Engl J Med 2000;343:463-7.

Conclusions ,[object Object],[object Object],[object Object],[object Object]

New MOA of Racecadotril ,[object Object],[object Object],[object Object]

What Is Enkephalinase? ,[object Object]

What Are Enkephalins? ,[object Object],[object Object],[object Object]

What Are Endogenous Opiates? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Types of Opiate Receptors ,[object Object],[object Object],[object Object],[object Object],mu - subtypes mu-1 and mu-2 kappa delta sigma 5 distinct types of opioid receptors are found in the body epsilon

What Can Happen… ,[object Object],[object Object]

Advantages of Racecadotril ,[object Object],[object Object],[object Object]

Significance of Racecadotril ,[object Object]

Pharmacokinetics of Racecadotril ,[object Object],[object Object],[object Object],[object Object]

Dosage Of Racecadotril ,[object Object],[object Object]

What About Loperamide? ,[object Object],[object Object],[object Object]

Comparison With Loperamide ,[object Object],[object Object],[object Object],[object Object],Scand J Gastroenterol. 2002 Jun;37(6):656-61, A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adult by Prado D; Global Adult Racecadotril Study Group, Hospital Centro Medico, Guatemala City, Guatemala.

Racecadotril: Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

Racecadotril: Potential Limitations ,[object Object],[object Object]

Conclusion ,[object Object],[object Object],[object Object],[object Object]

Racecadotril

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