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Classical Genetics
The Work and Conclusions of Gregor Mendel Father of genetics Monk in Austria 1865 Studied patterns of  inheritance  in peas
Why Peas?
Why Peas? Self-fertilization produces true breeding generations
[object Object],[object Object],[object Object],[object Object],Why Peas? Read Concept 1  Click Animation and View
Why Peas? Read Concept 2 Click Animation and View
Mendel’s Work Some traits are  dominant  and some are  recessive Read concept 3 Click animation and view Read concept 4 Click animation and view
Mendel’s Work ,[object Object],[object Object],[object Object]
Mendel’s Work Alleles are represented by the first letter of the dominant trait Pea plant flower color (trait) Purple or white Purple is dominant over white Alleles are represented as P=purple p=white
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mendel’s Work
Mendel’s Work Describing Traits  (Tall or short plants) Genotype The actual genetic make-up of an organism the “genes” Phenotype The physical appearance or form observed the “physical”
Mendel’s Work Possible Genotypes  (TT  Tt  tt) Homozygous The two alleles for the trait are identical TT homozygous dominant (purebred dominant) tt homozygous recessive (purebred recessive) Heterozygous The two alleles for the trait are different Tt heterozygote (hybrid)
Mendel’s Work
Mendel’s Work Read Concept 5 Click animation and view Complete visual organizer of Mendel’s pea plant experiment
1. Law of Dominance Alleles for a trait are   either dominant or recessive The dominant form is expressed and the recessive form is hidden The only way to express a recessive trait is if there are two copies of the recessive allele  Mendel’s Conclusions
 
Mendel’s Conclusions ,[object Object],[object Object]
Test Cross
Dihybrid Cross
Mendel’s 3 rd  Law of Independent Assortment ,[object Object],[object Object],[object Object]
Incomplete Dominance
“ Dominant” gene does not fully express itself to mask the effect of the recessive gene A pattern of inheritance in which the phenotype of a heterozygous individual is intermediate between those of the parents Genotypic ratio is equal to phenotypic ratio
Co-Dominance Two or more alleles are fully dominant When present together they are both expressed ABO Blood Groups exhibit co-dominace
Type A Blood ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Type B Blood ,[object Object],[object Object]
Type AB ,[object Object],[object Object],[object Object]
Type O ,[object Object],[object Object],[object Object]
 
 
 
 
Sex Inheritance Sex Chromosomes X or Y XX is female XY is male Read concept 9 Click animation and view
Sex-Linked Inheritance Genes linked to sex chromosomes
GENETIC  DISORDERS
Sources of Genetic Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Deletion ,[object Object],[object Object]
Duplication ,[object Object]
Translocation ,[object Object],[object Object],[object Object]
Inversion ,[object Object],[object Object],[object Object]
 
Nondisjunction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Turner Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object]
Down Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Klineflelter Syndrome ,[object Object],[object Object],[object Object],[object Object]
Cri-du-chat ,[object Object],[object Object],[object Object],[object Object]
Sex-linked Disorders
Hemophilia ,[object Object],[object Object],[object Object],•  inability to clot blood properly •  bruise easily •  many patients have been infected  with AIDS Hunters Syndrome
Autosomal Dominate Disorders
Neurofibromatosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Marfan Syndrome
Huntington Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Autosomal Recessive Disorders
Porphyria ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cystic Fibrosis ,[object Object],[object Object],[object Object]
Leprechanism ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Classical Genetics Lecture