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Genetic Foundations and 
Prenatal Environmental 
Influences 
Jan Augustine Paterno- 
Yamsuan
Embryology 
• The science of the development of 
an embryo from the fertilization of 
the ovum to the fetus stage. 
• Carnegie stages are a standardized 
system of 23 stages used to provide 
a unified developmental chronology 
of the vertebrate embryo.
Mitosis and Meiosis
Interphase 
• During interphase the chromosomes are 
dispersed in the nucleus and appear as a 
network of long, thin threads or filaments, 
called the chromatin. At some point before 
prophase begins, the chromosomes 
replicate themselves to form pairs of 
identical sister chromosomes, or 
chromatids; the deoxyribosenucleic acid 
(DNA) of the chromosomes is synthesized 
only during interphase not while mitosis is 
in process.
Prophase 
The two chromatids remain attached to one 
another at a region called the centromere, 
but each contracts into a compact tightly 
coiled cell body.; the nucleolus, and in 
most cases, the nuclear envelope breaks 
down and disappears. Also during this 
phase, spindle begins to form. In animal 
cells the centioles separate and move 
apart, and radiating bundles of fibers, 
called asters, appear around them.
Metaphase 
• Chromosomes congregate at a plane 
midway between the two ends to 
which the spindle tapers. This is 
called the equatorial plane and 
marks the point where the whole cell 
will divide when nuclear division is 
completed, the ends of the spindle 
are the poles to which the 
chromatids will migrate.
Anaphase 
• Two chromatids of each 
chromosome separate and 
move to opposite poles, as if 
pulled along the spindle fibers 
by the centromeres.
Telophase 
• New nucleoli begin to appear, 
and eventually, as the formation 
of the two daughter nuclei is 
completed, the spindle fibers 
disappear. The chromosomes 
uncoil to assume their 
dispersed distribution within the 
interphased nucleus.
• Gene: molecular unit of hereditary of 
a living organism. 
• Phenotype: composite of an 
organism’s observable traits. 
Phenotypes result from the 
expression of an organism’s genes 
as well as the influence of 
environmental factors and the 
interactions between the two.
• Genotype: genetic make up of 
an individual. 
• Allele: one of a number of 
alternative forms of the same 
gene or same genetic locus.
Environmental 
Influences 
• Teratogens : substances or 
environmental agents which 
cause the development of 
abnormal cell masses during 
fetal growth which result in 
physical defects in the fetus.

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171

  • 1. Genetic Foundations and Prenatal Environmental Influences Jan Augustine Paterno- Yamsuan
  • 2.
  • 3. Embryology • The science of the development of an embryo from the fertilization of the ovum to the fetus stage. • Carnegie stages are a standardized system of 23 stages used to provide a unified developmental chronology of the vertebrate embryo.
  • 5. Interphase • During interphase the chromosomes are dispersed in the nucleus and appear as a network of long, thin threads or filaments, called the chromatin. At some point before prophase begins, the chromosomes replicate themselves to form pairs of identical sister chromosomes, or chromatids; the deoxyribosenucleic acid (DNA) of the chromosomes is synthesized only during interphase not while mitosis is in process.
  • 6. Prophase The two chromatids remain attached to one another at a region called the centromere, but each contracts into a compact tightly coiled cell body.; the nucleolus, and in most cases, the nuclear envelope breaks down and disappears. Also during this phase, spindle begins to form. In animal cells the centioles separate and move apart, and radiating bundles of fibers, called asters, appear around them.
  • 7. Metaphase • Chromosomes congregate at a plane midway between the two ends to which the spindle tapers. This is called the equatorial plane and marks the point where the whole cell will divide when nuclear division is completed, the ends of the spindle are the poles to which the chromatids will migrate.
  • 8. Anaphase • Two chromatids of each chromosome separate and move to opposite poles, as if pulled along the spindle fibers by the centromeres.
  • 9. Telophase • New nucleoli begin to appear, and eventually, as the formation of the two daughter nuclei is completed, the spindle fibers disappear. The chromosomes uncoil to assume their dispersed distribution within the interphased nucleus.
  • 10. • Gene: molecular unit of hereditary of a living organism. • Phenotype: composite of an organism’s observable traits. Phenotypes result from the expression of an organism’s genes as well as the influence of environmental factors and the interactions between the two.
  • 11. • Genotype: genetic make up of an individual. • Allele: one of a number of alternative forms of the same gene or same genetic locus.
  • 12. Environmental Influences • Teratogens : substances or environmental agents which cause the development of abnormal cell masses during fetal growth which result in physical defects in the fetus.