Complementary and alternative medicine (CAM) use is common among patients with psoriasis. CAM modalities include traditional Chinese medicine (TCM), herbal therapies, dietary supplements, climatotherapy, and mind/body interventions. In this review, evidence from clinical trials investigating the efficacy of CAM for psoriasis is reviewed. There is a large amount of evidence from controlled trials that have shown that the combination of TCM with traditional therapies for psoriasis is more efficacious than traditional therapies alone. I have tried to analyze where are we i this therapeutic area.

1. PSORIASISPART ONE
Promising Therapeutic Area
JAYDEEP ADHIKARI

3. Around 3.0 million untreated population in US
More the 100 million affected globally
Around 20% severely affected diagnosed patient with psoriasis

4. JAK inhibitor
PDE4 inhibitor
Brodalumab
IL­17 blocker to prevent
Keratinocyte proliferation
Steroids
Vit. D3Immunosuppresant
IL­23 mediated T cell proliferation Interleukin blocker

5. Key Points
Market Value of about USD 3.9 billion
Projected growth of USD 7.4 billion by 2020
Topical formulation is most preferred
Top selling product 2014 Marketed Product by Targets
Market Share
Enbrel (Biologic Vs Synthetic product)

6. Top 3 Psoriasis Brand
(4 year historic sales & 4 year forecast)
Average of the top 3 product sales shows compounded annual growth rate of 10%

7. Around 150 molecule under development which suggest it is an valuable
therapeutic area
3 of the top 10 pharmaceutical majors have heavily invested in Psoriasis
therapeutic area
Pipeline by Development Phase
(YTD. Estimate)

8. Competitive Landscape

9. Target Pipeline

10. Average annual deal size > USD
400 mn
Max deal range b/w 50 -100 mn

11. How do we address the need
of mild to moderate
psoriasis?
How do we address the need
of pediatric population?