This document summarizes the goals and programs of the UCLA Clinical & Translational Science Institute (CTSI). The CTSI aims to advance translational research through 10 program areas, including clinical and community research resources, biostatistics, and career development programs. It provides various types of funding, including KL2 and TL1 awards, to support early career researchers and train the next generation of translational scientists. The document highlights recent awardees and accomplishments of the CTSI and its collaboration with other University of California institutions.

1. Leslie Raffel, MD
Associate Director and Cedars-Sinai Site Director,
UCLA Clinical & Translational Science Institute
NIH/ Career Development Award
Workshop
February 13, 2014
1
UCLA CTSI
Clinical and Translational Science Institute
www.ctsi.ucla.edu

2. Create an academic home for translational science
Advance team science
Train the next generation of translational scientists
Build bi-directional community partnerships
Promote inter-institutional collaborations
2
UCLA CTSI Goals

3. NIH CTSA Consortium

4. 4
UCLA CTSI translational investigation
extends from molecules to society
Translating knowledge gained from laboratory
science into clinical practice to improve health.
The aim of translational research is to produce new:
• therapeutics
• medical devices
• tools for diagnosing disease
• avenues for community engagement research
What is translational research?

5. 5
1) Clinical and Community Research Resources (CCRR)
2) Biomedical Informatics Program (BIP)
3) Community Engagement in Research Program (CERP)
4) Pilot and Collaborative Translational and Clinical Studies
Programs (Pilot)
5) Research Education, Training and Career Development
Program (CTSI-ED)
Program Areas (1-5)

6. 6
6) Biostatistics and Computational Biology Program
7) Center for Translational Technologies (CTT)
8) Maternal, Child and Adolescent Health (MCAH)
9) Regulatory Knowledge, Industry Relations and
Research Ethics Program (Regulatory)
10) Evaluation & Tracking
Program Areas (6-10)

7. 7
Opportunity Funds Grant Amount Duration of
Award (Years)
Award Cycle Application
Due Date
KL2 Awards:
to pursue interdisciplinary, mentored
research with training
Up to $125,000
in salary and
research support
1 year at 75%
effort
(renewable for
up to 3 years)
July 1 Full application:
February 24, 2014
TL1 Translational Science Fellowship:
PhD candidates in the Department of
Health Policy and Management in the
UCLA Fielding School of Public Health
receive mentored training to ensure
the translational nature of their
dissertation projects
Annual stipend
plus funding for
health
insurance,
tuition/fees, and
training-related
travel
Renewable for
up to 4 years
Annual UCLA School of
Public Health
application
deadline was
Dec 1, 2014
TL1 Summer Program for
Professional Students:
provides professional students
(medical, nursing and dental) early
exposure to interdisciplinary,
community-partnered translational
or health services research
Summer stipend
plus funding for
training-related
expenses
The summer
between
student’s first
and second
year (8 weeks)
June 1 March 28, 2014
Early Career Awards

8. Assistant Professor, CDU
“ Effects of Varenicline on Alcohol and Nicotine Consumption and
changes in Dopamine D2-like Receptor Availability in High-Alcohol
Preferring Mice”
Amira Brown, MS, PhDAmira Brown, MS, PhD
Assistant Professor, Pediatric Nephrology, UCLA
“ Hepcidin and the Anemia of Chronic Kidney Disease”
Joshua Zaritsky, MD, PhDJoshua Zaritsky, MD, PhD
Assistant Professor of Medicine, UCLA/VA
“ Patterns and Predictors of Poor Outcomes Following Emergency
Department Discharge in Older Adults”
Gelareh Gabayan, MD, MSHSGelareh Gabayan, MD, MSHS
KL2 Y1 Awardees

9. 9
Assistant Professor, UCLA-Harbor / LA-BioMed
“Using Research in Vancomycin-Resistant Enterococcus to Validate an
Efficient System of Quantifying Antibiotic Utilization”
James McKinnell, MDJames McKinnell, MD
Assistant Professor, UCLA
“Modeling of EMT/MET transitions in breast cancer stem cells”
Mary Sehl, MD, PhDMary Sehl, MD, PhD
Assistant Professor, UCLA
“Development of novel therapeutic strategies to target LKB1/STK11
deficient non-small cell lung cancer”
David Shackelford, PhDDavid Shackelford, PhD
KL2 Y2 Awardees

10. 10
Assistant Professor, UCLA
“Understanding the relationship between adolescent identity and
substance use”
Rebecca Dudovitz, MD, MSHSRebecca Dudovitz, MD, MSHS
Assistant Clinical Professor, Cedars-Sinai Medical Center
“Role of IL1-ß and the NLRP3 inflammasome in the development of
hypoxemia in acute lung injury”
Heather Jones, MDHeather Jones, MD
Assistant Professor, UCLA
“Single fraction vs. multiple fraction radiation for patients with
advanced cancer and painful bone metastases”
Anne Walling, MD, PhDAnne Walling, MD, PhD
KL2 Y3 Awardees
Clinical Instructor, UCLA
“Mechanisms Of Allograft Injury And The Development Of
Bronchiolitis Obliterans Syndrome After Lung Transplantation”
Michael Shino, MDMichael Shino, MD

11. 11
Assistant Clinical Professor, UCLA
“Relationship of physical activity to hippocampal structure and
memory in MCI”
David Merrill, MD, PhDDavid Merrill, MD, PhD
Assistant Professor, UCLA
“Gene expression profiles of ECT response in major depressive
disorder”
Eliza Congdon, PhDEliza Congdon, PhD
Assistant Professor, Cedars-Sinai Medical Center
“Minimizing errors in medication histories obtained at hospital
admission”
Joshua Pevnick, MD, MSHSJoshua Pevnick, MD, MSHS
KL2 Y3 Awardees
Assistant Professor, Charles Drew University of Medicine and Science
“Sensitization of castration-resistant prostate tumors to docetaxel
treatment by green tea and quercetin”
Piwen Wang, MD, PhD, MSPiwen Wang, MD, PhD, MS

12. The CTRC at Cedars-Sinai
Supports and supervises human studies and clinical
trials in all therapeutic areas and within all age groups
•5 exam/consultation rooms
•Bionutritionist
•Sample processing laboratory
•Experienced certified research nurses
•Mobile nurses
•Cost-sharing with reduced rates for new investigators
CTRC-Wide Accomplishments
•Clinical support for 426 new & existing projects
•9,048 out-patient & 5754 in-patient stays
Clinical and Translational Research Center (CTRC)

13. Biostatistics · Core Services · Pilot Funding · Education Activities
13banner “Cite It” card posters newsletters
Quarterly
publication
awards
Biostatistical Consults
• 8442 hours of statistical support provided
Vouchers
•Awarded 79 proposals
Pilot funding
•Awarded 73 pilot grants
($1.6 M in CTSI funds; $2.2 M institutional funds)
CTSI Education Activities
•>90 participants in K Award Workshops
•27 submitted draft proposals for review
More than 450 publications that received CTSI support
Watch for RFA coming soon!

14. 14banner “Cite It” card newsletters
UCLA
UC Davis
UC San Francisco
UC Irvine
UC San Diego
· Los Angeles Data Repository · UC Research Exchange
UC Research Exchange (UC-ReX)
Los Angeles Data Repository (LADR)
Cedars-Sinai