Combined effects of albuminuria and eGFR levels at baseline on the risk for adverse outcomes. The estimates are adjusted for baseline covariates, including age, sex, duration of diabetes, systolic blood pressure, history of currently treated hypertension, history of macrovascular disease, HbA1c, LDL cholesterol, HDL cholesterol, log-transformed triglycerides, BMI, electrocardiogram abnormalities, current smoking, and current drinking. Adapted with permission from Ninomiya et al. (13).