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Spontaneous pneumothorax:
Evidence-update
Anne-Maree Kelly
February 2013
Permissions
 This presentation may be reproduced in
whole or in part for educational purposes on
the condition that the following appears on
each slide:
‘Reproduced with the permission of
Professor Anne-Maree Kelly, Joseph
Epstein Centre for Emergency Medicine
Research @Western Health, Melbourne,
Australia’
@kellyam_jec
Learning objectives
 To review current evidence-based
guidelines for management of
spontaneous pneumothorax
 To apply evidence-based decision-
making to cases of spontaneous
pneumothorax
Getting started
 Which of the following is the main
determinant of ED therapeutic
intervention in primary spontaneous
pneumothorax?
◦ A. Pneumothorax size
◦ B. Presence or absence of
breathlessness
◦ C. Previous spontaneous pneumothorax
◦ D. Occupation
Mike
 Aged 19
 Onset of pleuritic
chest pain
yesterday
 Mildly SOB on
exertion
 At rest, pulse 60,
O2 sat 98% on
room air
What would you do?
 A. 36G intercostal catheter and UWSD
 B. Small bore ICC and heimlich valve/
UWSD
 C. Aspirate
 D. Conservative management
Would this xray change your mind?
Same
symptoms and
vital signs
Epidemiology
 Primary spontaneous pneumothorax is
a disease of the young
◦ Peak incidence late teens/ twenties
 Male> Female
 Smoking is a major risk factor
Clinical features
 Chest pain: 90%
◦ Sharp, dull
 Dyspnoea- can be transient
 Presentation delayed > 24 hours in
>50% of patients
 Signs
◦ Resonant chest
◦ Reduced breath sounds
◦ Often subtle
Imaging
 Chest xray
◦ Erect CXR is highly sensitive for clinically
relevant pnuemothorax
◦ Expiratory film adds little and should be avoided
◦ Supine films little use
 CT
◦ Highly sensitive and can identify other pathology
 Ultrasound
◦ Used in trauma but not widely accepted (yet) in
non-trauma
A question of size?
 No international agreement
 More difficult with electronic images!
 Australia
◦ Small: <2 cm rim around lung (measured
at hilum)
 US
◦ Small: <3cm inter-pleural distance at apex
Treatment
 Evidence base is NOT strong
 Factors to consider:
◦ Type of pneumothorax: primary or secondary.
◦ Clinical evidence of respiratory compromise,
in particular significant breathlessness
◦ Size. Pneumothoraces resolve at a rate of
approximately 1.25 to 2.2% of the volume of
hemithorax per day.
◦ Age. Evidence suggests that aspiration is
less successful in patients aged over 50.
◦ Cause of pneumothorax.
Emergent drainage
 Who?
◦ Patients with severe respiratory
compromise
◦ Patients with shock
 How?
◦ 14G IV catheter
◦ Small bore catheter (eg Cook’s) via
Seldinger technique
◦ Definitive treatment required
Minimal symptoms
 Evidence supports conservative
treatment irrespective of xray findings
 Re-absorb at rate of 1.5-2.3%
hemithorax/ day
 Can be managed at home!
 Follow-up
◦ Weekly
◦ Caveat: for early presenters (<24 hours),
may be prudent to check next day
Symptomatic
 Main indication for intervention is
presence of significant breathlessness
 Options
◦ Aspiration
◦ Catheter drainage
Aspiration
 Usually performed using a small catheter e.g.
Cooks
 Aim is to convert a large pneumothorax to a
small one
 Success = rim <2cm and resolution of
breathlessness without re-accumulation over 4-6
hours
 Success rate 50-80%
 If you have aspirated >3 L, success unlikely
◦ Connect to Heimlich valve or UWSD
Catheter drainage
 Small bore catheters (e.g. Cook’s) are as
effective as large catheters
 Success rate 65-95%
 Suction does not improve outcome and
should be avoided
 Trocars should not be used
Surgery
 About 10% of patients require surgical
intervention
 Indications:
◦ persistent air leak after 2-7 days
◦ recurrent pneumothoraces
◦ airline pilots, frequent plane travelers and
divers
◦ contralateral or bilateral pneumothoraces
and
◦ pregnancy
Recurrence
 Up to 50% after first pneumothorax
◦ Greatest risk in first year
 Up to 70% after subsequent
pneumothorax
Revisiting
 Which of the following is the main
determinant of ED therapeutic
intervention in primary spontaneous
pneumothorax?
◦ A. Pneumothorax size
◦ B. Presence or absence of
breathlessness
◦ C. Previous spontaneous pneumothorax
◦ D. Occupation
Revisiting
 Which of the following is the main
determinant of ED therapeutic
intervention in primary spontaneous
pneumothorax?
◦ A. Pneumothorax size
◦ B. Presence or absence of
breathlessness
◦ C. Previous spontaneous pneumothorax
◦ D. Occupation
Did you change your mind?
 Aged 19
 Onset of pleuritic
chest pain
yesterday
 Mildly SOB on
exertion
 At rest, pulse 60,
O2 sat 98% on
room air
Did you change your mind?
Same
symptoms and
vital signs
Spontaneous pneumothorax
If bilateral or haemodynamically unstable, proceed to catheter drainage
•Age >50 and significant smoking history
•Evidence of underlying lung disease on exam or CXR?
Primary pneumothorax Secondary pneumothorax
Size > 2cm or significant
breathlessness?
Consider discharge with followup
next day and 1-2 weekly
thereafter until resolution
Simple aspiration
Success :
- <3 litres aspirated AND
- size < 2cm on xray 4 hours post
aspiration AND
- no significant breathlessness
Catheter drainage
Admit
Size > 2cm or significant breathlessness?
Simple aspiration
Size <1cm
No
No
Yes*
Yes No
Yes
Yes No
Size <1cm Yes
No
Admit
High flow oxygen (unless
O2 sensitive)
Observe minimum 24
hours
No
* In some patients with a large pneumothorax but minimal symptoms
conservative management may be appropriate
An exercise in decision-
making
 Tim, aged 24
 Moderate primary spontaneous
pneumothorax on left (2cm rim)
 Symptoms> 24 hours
 Minimal symptoms
What would you do?
An exercise in decision-
making
 Tim, aged 24
 Moderate primary
spontaneous
pneumothorax on
left (2cm rim)
 Symptoms> 24
hours
 Minimal symptoms
 Would that that
change if:
 Tim had a previous
ipsilateral
pneumothorax?
 Tim was a pilot?
If so, what would
you do?
QUESTIONS
@kellyam_jec

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Treatment of spontaneous pneumothorax: Evidence-based update

  • 2. Permissions  This presentation may be reproduced in whole or in part for educational purposes on the condition that the following appears on each slide: ‘Reproduced with the permission of Professor Anne-Maree Kelly, Joseph Epstein Centre for Emergency Medicine Research @Western Health, Melbourne, Australia’ @kellyam_jec
  • 3. Learning objectives  To review current evidence-based guidelines for management of spontaneous pneumothorax  To apply evidence-based decision- making to cases of spontaneous pneumothorax
  • 4. Getting started  Which of the following is the main determinant of ED therapeutic intervention in primary spontaneous pneumothorax? ◦ A. Pneumothorax size ◦ B. Presence or absence of breathlessness ◦ C. Previous spontaneous pneumothorax ◦ D. Occupation
  • 5. Mike  Aged 19  Onset of pleuritic chest pain yesterday  Mildly SOB on exertion  At rest, pulse 60, O2 sat 98% on room air
  • 6. What would you do?  A. 36G intercostal catheter and UWSD  B. Small bore ICC and heimlich valve/ UWSD  C. Aspirate  D. Conservative management
  • 7. Would this xray change your mind? Same symptoms and vital signs
  • 8. Epidemiology  Primary spontaneous pneumothorax is a disease of the young ◦ Peak incidence late teens/ twenties  Male> Female  Smoking is a major risk factor
  • 9. Clinical features  Chest pain: 90% ◦ Sharp, dull  Dyspnoea- can be transient  Presentation delayed > 24 hours in >50% of patients  Signs ◦ Resonant chest ◦ Reduced breath sounds ◦ Often subtle
  • 10. Imaging  Chest xray ◦ Erect CXR is highly sensitive for clinically relevant pnuemothorax ◦ Expiratory film adds little and should be avoided ◦ Supine films little use  CT ◦ Highly sensitive and can identify other pathology  Ultrasound ◦ Used in trauma but not widely accepted (yet) in non-trauma
  • 11. A question of size?  No international agreement  More difficult with electronic images!  Australia ◦ Small: <2 cm rim around lung (measured at hilum)  US ◦ Small: <3cm inter-pleural distance at apex
  • 12. Treatment  Evidence base is NOT strong  Factors to consider: ◦ Type of pneumothorax: primary or secondary. ◦ Clinical evidence of respiratory compromise, in particular significant breathlessness ◦ Size. Pneumothoraces resolve at a rate of approximately 1.25 to 2.2% of the volume of hemithorax per day. ◦ Age. Evidence suggests that aspiration is less successful in patients aged over 50. ◦ Cause of pneumothorax.
  • 13. Emergent drainage  Who? ◦ Patients with severe respiratory compromise ◦ Patients with shock  How? ◦ 14G IV catheter ◦ Small bore catheter (eg Cook’s) via Seldinger technique ◦ Definitive treatment required
  • 14. Minimal symptoms  Evidence supports conservative treatment irrespective of xray findings  Re-absorb at rate of 1.5-2.3% hemithorax/ day  Can be managed at home!  Follow-up ◦ Weekly ◦ Caveat: for early presenters (<24 hours), may be prudent to check next day
  • 15. Symptomatic  Main indication for intervention is presence of significant breathlessness  Options ◦ Aspiration ◦ Catheter drainage
  • 16. Aspiration  Usually performed using a small catheter e.g. Cooks  Aim is to convert a large pneumothorax to a small one  Success = rim <2cm and resolution of breathlessness without re-accumulation over 4-6 hours  Success rate 50-80%  If you have aspirated >3 L, success unlikely ◦ Connect to Heimlich valve or UWSD
  • 17. Catheter drainage  Small bore catheters (e.g. Cook’s) are as effective as large catheters  Success rate 65-95%  Suction does not improve outcome and should be avoided  Trocars should not be used
  • 18. Surgery  About 10% of patients require surgical intervention  Indications: ◦ persistent air leak after 2-7 days ◦ recurrent pneumothoraces ◦ airline pilots, frequent plane travelers and divers ◦ contralateral or bilateral pneumothoraces and ◦ pregnancy
  • 19. Recurrence  Up to 50% after first pneumothorax ◦ Greatest risk in first year  Up to 70% after subsequent pneumothorax
  • 20. Revisiting  Which of the following is the main determinant of ED therapeutic intervention in primary spontaneous pneumothorax? ◦ A. Pneumothorax size ◦ B. Presence or absence of breathlessness ◦ C. Previous spontaneous pneumothorax ◦ D. Occupation
  • 21. Revisiting  Which of the following is the main determinant of ED therapeutic intervention in primary spontaneous pneumothorax? ◦ A. Pneumothorax size ◦ B. Presence or absence of breathlessness ◦ C. Previous spontaneous pneumothorax ◦ D. Occupation
  • 22. Did you change your mind?  Aged 19  Onset of pleuritic chest pain yesterday  Mildly SOB on exertion  At rest, pulse 60, O2 sat 98% on room air
  • 23. Did you change your mind? Same symptoms and vital signs
  • 24. Spontaneous pneumothorax If bilateral or haemodynamically unstable, proceed to catheter drainage •Age >50 and significant smoking history •Evidence of underlying lung disease on exam or CXR? Primary pneumothorax Secondary pneumothorax Size > 2cm or significant breathlessness? Consider discharge with followup next day and 1-2 weekly thereafter until resolution Simple aspiration Success : - <3 litres aspirated AND - size < 2cm on xray 4 hours post aspiration AND - no significant breathlessness Catheter drainage Admit Size > 2cm or significant breathlessness? Simple aspiration Size <1cm No No Yes* Yes No Yes Yes No Size <1cm Yes No Admit High flow oxygen (unless O2 sensitive) Observe minimum 24 hours No * In some patients with a large pneumothorax but minimal symptoms conservative management may be appropriate
  • 25. An exercise in decision- making  Tim, aged 24  Moderate primary spontaneous pneumothorax on left (2cm rim)  Symptoms> 24 hours  Minimal symptoms What would you do?
  • 26. An exercise in decision- making  Tim, aged 24  Moderate primary spontaneous pneumothorax on left (2cm rim)  Symptoms> 24 hours  Minimal symptoms  Would that that change if:  Tim had a previous ipsilateral pneumothorax?  Tim was a pilot? If so, what would you do?