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AUTISM SPECTRUM DISORDERS

        Kristen Burke
The autism spectrum disorders
The Autism Spectrum Disorders

 PDD-NOS
 Retts Syndrome
 Asperger’s syndrome
 Childhood Disintegration Syndrome
1 in every 110 children          The prevalence rate
are diagnosed with an            increases from 10% to 17%
Autism Spectrum                  every year
Disorder
                                 Autism Spectrum
                                 Disorders are more
  Boys are more                  common than childhood
  likely to develop              cancer, pediatric AIDs,
  autism than girls              and juvenile diabetes
                                 combined

Boys are diagnosed 3-4 times more often
                                              1.5 million
than girls
                                              Americans are
                                              affected and
 1 out of every 70 boys is                    10s of millions
 diagnosed in the US alone                    are affected
                                              world wide
Autism
What is autism?
“Autism is a general term used to describe a
group of complex developments brain
disorders known as Pervasive Developmental
Disorders (PDD)”
              ~ from the autismspeaks website
What causes autism?
 Most causes are idiopathic, meaning we don’t
  know what causes them
 When autism was first discovered, people
  thought that it was caused by bad mothering
 During the 1960s and 70s, Dr. Bernard Rimland
  helped correct that theory
 He proved that it is caused by a biological
  disorder, not by bad parenting
 Dr. Bernard Rimland, who had a son with
  autism, later went on to found the Autism
  Society of America
 We do know some factors that may contribute
  to autism
Genetic Disorders

o Fragile X


o Tuberous Sclerosis


o Angelman’s syndrome
Environments agents (possibly
infectious) (affects during
pregnancy)
o Maternal rubella


o cytomegalovirus
Environmental Agents (chemical)
(affects during pregnancy)

o Thalidomide


o Valproate
Role of the immune system


o Possibly caused by inflammation of the
  central nervous system

o Animal studies show that an inflamed central
  nervous system can cause autism like
  behaviors
NOT cause by bad parenting

o Autism was first described as a “unique
  condition” by Dr. Leo Kanner in 1943
o He declared that it was a condition caused by
  “cruel, cold, unloving mothers”
How do you diagnose autism?
 There isn't currently a specific medical test to
  test for autism
 It is diagnosed through observation and
  psychological testing
 Symptoms vary, and so do the methods for
  diagnosing autism
 Sometimes a pediatrician doesn’t take a parents
  concern seriously and a diagnosis is delayed
What are the symptoms of autism?
 Symptom types:
   Background to symptoms
   Social symptoms
   Communication difficulties
   Repetitive behaviors
Background to Symptoms
 Autism affects the way a child interprets the world
 It can make communication difficult
 It can make social interaction difficult
 There can be repetitive behaviors
 There can be very intense interests
 One child with autism may have very different symptoms
  than another child with autism
 symptoms of autism usually last throughout someone's life
  time
 When a person is severely affected, they may not be able to
  speak or care for themselves
 Early intervention can make huge differences on the severity
  of a person’s symptoms
Social Symptoms
 Most children, form the beginning, are very social. They
  smile, wave, and turn towards voices. Affected children can
  be indifferent to average human interactions. They have
  trouble picking up simple social interactions that other
  children learn subconsciously. In their first year of life, and
  affected child may not interact or make eye contact.
 Affected children may be indifferent to other peoples
  interactions and they may prefer being alone. They may
  accept hugs and affection passively or resist it.
 Later on, they might not look to their parents for affection.
  They can react differently to anger or affection from their
  parents. Kids with autism are attached to their parents, but
  have a different way of showing their affection. To parents, it
  may seem like their child is not attached at all.
Social Symptoms

 Children with autism may take longer to what others are
  thinking or feeling. They don’t understand social cues like a
  smile, wave, or grimace, as easily as other children.
 Children may have trouble seeing things from another
  person’s perspective, and therefore, they have trouble
  predicting how others will react to certain things. They can
  have trouble regulating emotions, which can take the form
  of “immature behavior.” They may cry, have verbal
  outbursts, be disruptive in certain settings, or be physically
  aggressive. When in an overwhelming environment, they can
  “lose control,” which can result in actions like hair pulling or
  arm biting.
Communication Difficulties

 Some children with autism will remain mute all their life and
  learn other forms of communication like sign language or
  picture sign language. Other children learn to talk and
  babble when they are little and then lose the skills they have
  gained. Others wont talk until ages 5,6,7,8 or even 9 years
  old.
 Children with autism have a harder time expressing to others
  what they need or want and as a result may jut grab things or
  scream. As kids grow up, they may become aware of this
  difficulty and become anxious or depressed.
Repetitive Behaviors
 Children with autism may not look physically different, but
  they can have odd, repetitive motions. These motions can
  range from abrupt and obvious actions to very subtle ones.
  Some children may flap their arms, some may walk on their
  toes, and some may just freeze in a position they are in.
 Children with autism spend more time lining up their
  toys, like toy cars, in specific orders rather than playing
  imaginary games with them. If somebody disrupts the order
  of the toys, it can be very stressful to the child.
 Repetitive behaviors can also take the form of interests.
  Some of these interests can be very intense interests even if
  it is in something many people don’t find all that interesting.
 Children with autism need consistency in their environment.
  Changes in the environment or in their schedule can be
  extremely stressful.
What are other medical issues
that may accompany autism?
Seizure Disorders
o Called Epilepsy
o Occurs in 39% of people with autism
o It occurs more often in people with “cognitive defects” than in people
    with out
o    some studies say its more common in children that have had a
    regression of skills
o   There are different types of seizures
     o Grand mal – easy to spot
     o Petite mal – sometimes only seen on and EEG
     o Sub clinical – not clear whether these affect language development
o    usually start early in life, but can happen any time
o   Tests:
     o EEG (electroencephalogram)
     o MRI (magnetic resonance imaging)
     o CT (computed axial tomography)
     o CBC (complete blood count)
o   People can be treated with anticonvulsant to reduce/eliminate
    occurrences
Genetic Disorders

o Fragile X Syndrome
o Angelman’s Syndrome
o Tuberous Sclerosis
o Chromosome 15 Duplication Syndrome
o Or another chromosome disorder
Gastrointestinal Disorders

   Gastritis
   Chronic constipation
   Colitis
   Celiac disease
   Esophogitis
o The exact number of children with autism and
  gastrointestinal problems is unknown
o Studies say it is anywhere between 46% and 85%
o A popular “solution” to these problems is to
  remove dairy and gluten from the child’s diet
Sleep Dysfunction

o When the dysfunction is caused by a medical
  disorder like obstructive sleep apnea or
  gastrointestinal reflux, it can be cured by a
  doctor
o When it isn’t caused by a medical problem, it
  can be treated with “sleep hygiene.” that
  means doing things like setting up a regular
  bedtime, having a bedtime routine, and
  limiting the hours of sleep
Sensory Integration Dysfunction
o Many children with autism react differently to sensory input
    or stimulation
o   Hearing, vision, touch, smell, taste, sense of movement, and
    sense of position can all be affected
o   Information is being senses normally by the child, but is
    being perceived much differently
o    stimulation that may seem normal to another child can be
    perceived as painful, unpleasant, or confusing
o   Sensory Integration Dysfunctions include:
    o Hypersensitivity
      o Not being able to wear cloths
      o Not able to be touched
      o Not able to be in a room with normal lighting
    o Hyposensitivity
      o Increased tolerance of pain
      o Constant need for stimulation
Pica

 o Pica is an eating disorder that includes eating
   things that aren’t food
 o This is normal behavior between 18 and 24
   months, but it can continue after this period of
   time with an autistic child
 o They tend to eat things like dirt, clay, chalk, and
   paint chips
 o A sign of pica is if a child is constantly mouthing
   on fingers or other objects
 o Children that do this should be tested for lead in
   their blood
Red Flags of Autism

 If there is no warm or joyful expressions by 6
  months or after
 If there is no back and forth or sounds, smiles, or
  facial expressions by 9 months or after
 If there is no babbling by 12 months or after
 If there is no back and forth gestures
  (pointing/showing/reacting/waving) by 12
  months or after
 If there are no words by 16 months or after
 If there are no two word meaningful phrases (not
  imitation/repetition) by 24 months
 Any loss of speech or babbling at any age
Asperger’s syndrome
What is Asperger’s Syndrome?
Asperger’s Syndrome is an autism spectrum
disorder that is milder than autism but shares
most of the same symptoms
What causes Asperger’s Syndrome?
Cases of Asperger’s Syndrome are
idiopathic, meaning we don’t know what causes
them
What are the symptoms of
Asperger’s Syndrome?
 An obsessive interest in any subject

 Trouble recognizing common social cues

 Difficulty with motor skills

 Poor communication skills
Retts syndrome
What is Retts Syndrome?
Retts Syndrome is a neurodevelopmental
disorder that begins to show its affects in
early childhood. It is almost exclusively found
in females, but all racial and ethnic groups
can be affected by it.
What causes Retts Syndrome?
Retts Syndrome is caused by a mutation in the
MECP2 gene in the X chromosome
What are the symptoms of Retts
Syndrome
 3-5 months: slowing of head growth
 6-18 months: learning to crawl later than
  usual, ceasing to learn new skills, diminished
  muscle tone, decreased eye contact, inattentive
  behavior
 1-4 years: loss of previously acquired skills
 2-10 years: recession of skills stops, motor skill
  difficulties become more pronounced, seizures
  become more pronounced
 10 years and older: developing motor skill
  difficulties, muscle weakening gets worse
Childhood disintigration disorder
What is Childhood Disintegration
Disorder
Childhood Disintegration Disorder is a
condition where a child will develop
normally, but when they reach the age of
about 3 or 4, they lose their
language, motor, social, and other skills that
they have already learned
What causes Childhood
Disintegration Disorder
Childhood Disintegration Disorder is an
idiopathic condition, meaning we don’t know
what causes it
What are the symptoms of
Childhood Disintegration
Disorder?
 Lose communication skills
 Lose nonverbal behaviors
 Lose skills already learned
 Decay of spoken language
 Lack of spoken language
 Inability to start or maintain a conversation
 Lack of playing
 Lose bladder/bowel control
 Lose language skills
 Lose social skills
 Problems forming relationships with friends and
  family members
PDD-NOS
What is PDD-NOS?
Pervasive Developementa Disorders – Not
Otherwise Specified (PDD-NOS) are
conditions on the autism spectrum that
exhibit some, but not all of the symptoms of
autism
What causes PDD-NOS?
PDD-NOS are idiopathic conditions, meaning
we don’t know what causes them
What are the symptoms of PDD-NOS?
 People may appear unemotional to others

 People may possibly be unable to speak

 People have trouble holding eye contact

 People have trouble transitioning activities
Bibliography

 http://www.autismspeaks.org/whatisit/index.php

 http://www.rettsyndrome.org/about-rett-syndrome.html

 http://www.wemove.org/rett/rett_sym.html

 http://www.nlm.nih.gov/medlineplus/ency/article/001535.
  htm
 http://kidshealth.org/parent/medical/brain/asperger.html
  #
 http://www.autismspeaks.org/navigations/pdd_nos.php

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Autism spectrum disorders

  • 1. Due 12/10/10 AUTISM SPECTRUM DISORDERS Kristen Burke
  • 3. The Autism Spectrum Disorders  PDD-NOS  Retts Syndrome  Asperger’s syndrome  Childhood Disintegration Syndrome
  • 4. 1 in every 110 children The prevalence rate are diagnosed with an increases from 10% to 17% Autism Spectrum every year Disorder Autism Spectrum Disorders are more Boys are more common than childhood likely to develop cancer, pediatric AIDs, autism than girls and juvenile diabetes combined Boys are diagnosed 3-4 times more often 1.5 million than girls Americans are affected and 1 out of every 70 boys is 10s of millions diagnosed in the US alone are affected world wide
  • 7. “Autism is a general term used to describe a group of complex developments brain disorders known as Pervasive Developmental Disorders (PDD)” ~ from the autismspeaks website
  • 9.  Most causes are idiopathic, meaning we don’t know what causes them  When autism was first discovered, people thought that it was caused by bad mothering  During the 1960s and 70s, Dr. Bernard Rimland helped correct that theory  He proved that it is caused by a biological disorder, not by bad parenting  Dr. Bernard Rimland, who had a son with autism, later went on to found the Autism Society of America
  • 10.  We do know some factors that may contribute to autism
  • 11. Genetic Disorders o Fragile X o Tuberous Sclerosis o Angelman’s syndrome
  • 12. Environments agents (possibly infectious) (affects during pregnancy) o Maternal rubella o cytomegalovirus
  • 13. Environmental Agents (chemical) (affects during pregnancy) o Thalidomide o Valproate
  • 14. Role of the immune system o Possibly caused by inflammation of the central nervous system o Animal studies show that an inflamed central nervous system can cause autism like behaviors
  • 15. NOT cause by bad parenting o Autism was first described as a “unique condition” by Dr. Leo Kanner in 1943 o He declared that it was a condition caused by “cruel, cold, unloving mothers”
  • 16. How do you diagnose autism?
  • 17.  There isn't currently a specific medical test to test for autism  It is diagnosed through observation and psychological testing  Symptoms vary, and so do the methods for diagnosing autism  Sometimes a pediatrician doesn’t take a parents concern seriously and a diagnosis is delayed
  • 18. What are the symptoms of autism?
  • 19.  Symptom types:  Background to symptoms  Social symptoms  Communication difficulties  Repetitive behaviors
  • 20. Background to Symptoms  Autism affects the way a child interprets the world  It can make communication difficult  It can make social interaction difficult  There can be repetitive behaviors  There can be very intense interests  One child with autism may have very different symptoms than another child with autism  symptoms of autism usually last throughout someone's life time  When a person is severely affected, they may not be able to speak or care for themselves  Early intervention can make huge differences on the severity of a person’s symptoms
  • 21. Social Symptoms  Most children, form the beginning, are very social. They smile, wave, and turn towards voices. Affected children can be indifferent to average human interactions. They have trouble picking up simple social interactions that other children learn subconsciously. In their first year of life, and affected child may not interact or make eye contact.  Affected children may be indifferent to other peoples interactions and they may prefer being alone. They may accept hugs and affection passively or resist it.  Later on, they might not look to their parents for affection. They can react differently to anger or affection from their parents. Kids with autism are attached to their parents, but have a different way of showing their affection. To parents, it may seem like their child is not attached at all.
  • 22. Social Symptoms  Children with autism may take longer to what others are thinking or feeling. They don’t understand social cues like a smile, wave, or grimace, as easily as other children.  Children may have trouble seeing things from another person’s perspective, and therefore, they have trouble predicting how others will react to certain things. They can have trouble regulating emotions, which can take the form of “immature behavior.” They may cry, have verbal outbursts, be disruptive in certain settings, or be physically aggressive. When in an overwhelming environment, they can “lose control,” which can result in actions like hair pulling or arm biting.
  • 23. Communication Difficulties  Some children with autism will remain mute all their life and learn other forms of communication like sign language or picture sign language. Other children learn to talk and babble when they are little and then lose the skills they have gained. Others wont talk until ages 5,6,7,8 or even 9 years old.  Children with autism have a harder time expressing to others what they need or want and as a result may jut grab things or scream. As kids grow up, they may become aware of this difficulty and become anxious or depressed.
  • 24. Repetitive Behaviors  Children with autism may not look physically different, but they can have odd, repetitive motions. These motions can range from abrupt and obvious actions to very subtle ones. Some children may flap their arms, some may walk on their toes, and some may just freeze in a position they are in.  Children with autism spend more time lining up their toys, like toy cars, in specific orders rather than playing imaginary games with them. If somebody disrupts the order of the toys, it can be very stressful to the child.  Repetitive behaviors can also take the form of interests. Some of these interests can be very intense interests even if it is in something many people don’t find all that interesting.  Children with autism need consistency in their environment. Changes in the environment or in their schedule can be extremely stressful.
  • 25. What are other medical issues that may accompany autism?
  • 26. Seizure Disorders o Called Epilepsy o Occurs in 39% of people with autism o It occurs more often in people with “cognitive defects” than in people with out o some studies say its more common in children that have had a regression of skills o There are different types of seizures o Grand mal – easy to spot o Petite mal – sometimes only seen on and EEG o Sub clinical – not clear whether these affect language development o usually start early in life, but can happen any time o Tests: o EEG (electroencephalogram) o MRI (magnetic resonance imaging) o CT (computed axial tomography) o CBC (complete blood count) o People can be treated with anticonvulsant to reduce/eliminate occurrences
  • 27. Genetic Disorders o Fragile X Syndrome o Angelman’s Syndrome o Tuberous Sclerosis o Chromosome 15 Duplication Syndrome o Or another chromosome disorder
  • 28. Gastrointestinal Disorders  Gastritis  Chronic constipation  Colitis  Celiac disease  Esophogitis o The exact number of children with autism and gastrointestinal problems is unknown o Studies say it is anywhere between 46% and 85% o A popular “solution” to these problems is to remove dairy and gluten from the child’s diet
  • 29. Sleep Dysfunction o When the dysfunction is caused by a medical disorder like obstructive sleep apnea or gastrointestinal reflux, it can be cured by a doctor o When it isn’t caused by a medical problem, it can be treated with “sleep hygiene.” that means doing things like setting up a regular bedtime, having a bedtime routine, and limiting the hours of sleep
  • 30. Sensory Integration Dysfunction o Many children with autism react differently to sensory input or stimulation o Hearing, vision, touch, smell, taste, sense of movement, and sense of position can all be affected o Information is being senses normally by the child, but is being perceived much differently o stimulation that may seem normal to another child can be perceived as painful, unpleasant, or confusing o Sensory Integration Dysfunctions include: o Hypersensitivity o Not being able to wear cloths o Not able to be touched o Not able to be in a room with normal lighting o Hyposensitivity o Increased tolerance of pain o Constant need for stimulation
  • 31. Pica o Pica is an eating disorder that includes eating things that aren’t food o This is normal behavior between 18 and 24 months, but it can continue after this period of time with an autistic child o They tend to eat things like dirt, clay, chalk, and paint chips o A sign of pica is if a child is constantly mouthing on fingers or other objects o Children that do this should be tested for lead in their blood
  • 32. Red Flags of Autism  If there is no warm or joyful expressions by 6 months or after  If there is no back and forth or sounds, smiles, or facial expressions by 9 months or after  If there is no babbling by 12 months or after  If there is no back and forth gestures (pointing/showing/reacting/waving) by 12 months or after  If there are no words by 16 months or after  If there are no two word meaningful phrases (not imitation/repetition) by 24 months  Any loss of speech or babbling at any age
  • 34. What is Asperger’s Syndrome?
  • 35. Asperger’s Syndrome is an autism spectrum disorder that is milder than autism but shares most of the same symptoms
  • 37. Cases of Asperger’s Syndrome are idiopathic, meaning we don’t know what causes them
  • 38. What are the symptoms of Asperger’s Syndrome?
  • 39.  An obsessive interest in any subject  Trouble recognizing common social cues  Difficulty with motor skills  Poor communication skills
  • 41. What is Retts Syndrome?
  • 42. Retts Syndrome is a neurodevelopmental disorder that begins to show its affects in early childhood. It is almost exclusively found in females, but all racial and ethnic groups can be affected by it.
  • 43. What causes Retts Syndrome?
  • 44. Retts Syndrome is caused by a mutation in the MECP2 gene in the X chromosome
  • 45. What are the symptoms of Retts Syndrome
  • 46.  3-5 months: slowing of head growth  6-18 months: learning to crawl later than usual, ceasing to learn new skills, diminished muscle tone, decreased eye contact, inattentive behavior  1-4 years: loss of previously acquired skills  2-10 years: recession of skills stops, motor skill difficulties become more pronounced, seizures become more pronounced  10 years and older: developing motor skill difficulties, muscle weakening gets worse
  • 48. What is Childhood Disintegration Disorder
  • 49. Childhood Disintegration Disorder is a condition where a child will develop normally, but when they reach the age of about 3 or 4, they lose their language, motor, social, and other skills that they have already learned
  • 51. Childhood Disintegration Disorder is an idiopathic condition, meaning we don’t know what causes it
  • 52. What are the symptoms of Childhood Disintegration Disorder?
  • 53.  Lose communication skills  Lose nonverbal behaviors  Lose skills already learned  Decay of spoken language  Lack of spoken language  Inability to start or maintain a conversation  Lack of playing  Lose bladder/bowel control  Lose language skills  Lose social skills  Problems forming relationships with friends and family members
  • 56. Pervasive Developementa Disorders – Not Otherwise Specified (PDD-NOS) are conditions on the autism spectrum that exhibit some, but not all of the symptoms of autism
  • 58. PDD-NOS are idiopathic conditions, meaning we don’t know what causes them
  • 59. What are the symptoms of PDD-NOS?
  • 60.  People may appear unemotional to others  People may possibly be unable to speak  People have trouble holding eye contact  People have trouble transitioning activities
  • 61. Bibliography  http://www.autismspeaks.org/whatisit/index.php  http://www.rettsyndrome.org/about-rett-syndrome.html  http://www.wemove.org/rett/rett_sym.html  http://www.nlm.nih.gov/medlineplus/ency/article/001535. htm  http://kidshealth.org/parent/medical/brain/asperger.html #  http://www.autismspeaks.org/navigations/pdd_nos.php