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Medical bioinformatics: Current trends, industry needs, and core competencies
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Past civilisations have nurtured small populations of those trying to understand and manipulate nature to some advantage in materials, tools, weapons, food, and wealth. However, they never formed communities and lacked the means of recording, communicating, and sharing successes and failures. They also lacked a common framework/philosophy to qualify them as scientists, but that all began to change in the 16th Century. In this lecture we consider the progression to a philosophy of science, and the underlying principles and assumptions that now guide scientific inquiry.We also examines the nature of scientific knowledge, the methods of acquisition, evolution, and significance over past centuries, and reflect on the value to society. In the struggle to solve problems, deliver understanding, and reveal the truth about our universe, science had to suffer and survive: ignorance, bigotry, established superstitions, and the ‘diktats’ of religions and politics, and latterly, falling education standards mired by social media. We chart that ‘scientific’ journey emphasising the importance of observation, experimentation, and the search for universal laws. Ultimately, this essentially Aristotelian perspective was challenged and overtaken by the rise of empiricism, which emphasised the importance of sensory experience and the limitations of human knowledge. Science continues to evolve and provide us with the best truths attainable with our leading edge technologies of observation and experimentation. Today, it stands as the greatest and richest contributor to human knowledge, understanding, progress, and wellbeing. In turn, debates and controversies are ongoing, shaping the field and philosophy which remains essential for understanding the nature of scientific knowledge and the models it creates. But unlike any belief system, the answers and models furnishers by science are not certain and invariant, they tend to be stochastic and incomplete - ‘the best we can do’ at a given time.
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The Philosophy of Science
University of Hertfordshire
Context. WASP-76 b has been a recurrent subject of study since the detection of a signature in high-resolution transit spectroscopy data indicating an asymmetry between the two limbs of the planet. The existence of this asymmetric signature has been confirmed by multiple studies, but its physical origin is still under debate. In addition, it contrasts with the absence of asymmetry reported in the infrared (IR) phase curve. Aims. We provide a more comprehensive dataset of WASP-76 b with the goal of drawing a complete view of the physical processes at work in this atmosphere. In particular, we attempt to reconcile visible high-resolution transit spectroscopy data and IR broadband phase curves. Methods. We gathered 3 phase curves, 20 occultations, and 6 transits for WASP-76 b in the visible with the CHEOPS space telescope. We also report the analysis of three unpublished sectors observed by the TESS space telescope (also in the visible), which represents 34 phase curves. Results. WASP-76 b displays an occultation of 260±11 and 152±10 ppm in TESS and CHEOPS bandpasses respectively. Depending on the composition assumed for the atmosphere and the data reduction used for the IR data, we derived geometric albedo estimates that range from 0.05 ± 0.023 to 0.146 ± 0.013 and from <0.13 to 0.189 ± 0.017 in the CHEOPS and TESS bandpasses, respectively. As expected from the IR phase curves, a low-order model of the phase curves does not yield any detectable asymmetry in the visible either. However, an empirical model allowing for sharper phase curve variations offers a hint of a flux excess before the occultation, with an amplitude of ∼40 ppm, an orbital offset of ∼−30◦ , and a width of ∼20◦ . We also constrained the orbital eccentricity of WASP-76 b to a value lower than 0.0067, with a 99.7% confidence level. This result contradicts earlier proposed scenarios aimed at explaining the asymmetry observed in high-resolution transit spectroscopy. Conclusions. In light of these findings, we hypothesise that WASP-76 b could have night-side clouds that extend predominantly towards its eastern limb. At this limb, the clouds would be associated with spherical droplets or spherically shaped aerosols of an unknown species, which would be responsible for a glory effect in the visible phase curves.
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Sérgio Sacani
Context. Determining the size distribution of asteroids is key to understanding the collisional history and evolution of the inner Solar System. Aims. We aim to improve our knowledge of the size distribution of small asteroids in the main belt by determining the parallaxes of newly detected asteroids in the Hubble Space Telescope (HST) archive and subsequently their absolute magnitudes and sizes. Methods. Asteroids appear as curved trails in HST images because of the parallax induced by the fast orbital motion of the spacecraft. Taking into account the trajectory of this latter, the parallax effect can be computed to obtain the distance to the asteroids by fitting simulated trajectories to the observed trails. Using distance, we can obtain the absolute magnitude of an object and an estimation of its size assuming an albedo value, along with some boundaries for its orbital parameters. Results. In this work, we analyse a set of 632 serendipitously imaged asteroids found in the ESA HST archive. Images were captured with the ACS/WFC and WFC3/UVIS instruments. A machine learning algorithm (trained with the results of a citizen science project) was used to detect objects in these images as part of a previous study. Our raw data consist of 1031 asteroid trails from unknown objects, not matching any entries in the Minor Planet Center (MPC) database using their coordinates and imaging time. We also found 670 trails from known objects (objects featuring matching entries in the MPC). After an accuracy assessment and filtering process, our analysed HST asteroid set consists of 454 unknown objects and 178 known objects. We obtain a sample dominated by potential main belt objects featuring absolute magnitudes (H) mostly between 15 and 22 mag. The absolute magnitude cumulative distribution logN(H > H0) ∝ αlog(H0) confirms the previously reported slope change for 15 < H < 18, from α ≈ 0.56 to α ≈ 0.26, maintained in our case down to absolute magnitudes of around H ≈ 20, and therefore expanding the previous result by approximately two magnitudes. Conclusions. HST archival observations can be used as an asteroid survey because the telescope pointings are statistically randomly oriented in the sky and cover long periods of time. They allow us to expand the current best samples of astronomical objects at no extra cost in regard to telescope time.
Hubble Asteroid Hunter III. Physical properties of newly found asteroids
Hubble Asteroid Hunter III. Physical properties of newly found asteroids
Sérgio Sacani
Microbiology Lecture (Unit 2) according to Pakistan Nursing council (PNC) course outline for Bachelor of Science in Nursing (Generic) students.
GBSN - Microbiology (Unit 2)
GBSN - Microbiology (Unit 2)
Areesha Ahmad
On 26 January 2023, a military pilot reported four potential unidentified anomalous phenomena (UAP) while operating in the Eglin Air Force Base training range off the coast of Florida. Through the onboard radar system, the pilot initially observed that the four objects were aloft between 16,000 – 18,000 feet and appeared to be flying in formation. However the pilot observed only one of the four objects visually and captured two images of the single object via the aircraft’s electro-optical/infrared (EO/IR) sensor (see Figures 1A and 1B). The pilot could not record video of the event because the aircraft’s video recording equipment was inoperable prior to and during the aircraft’s flight. The pilot observed this single object aloft at 16,000 feet. The following case information is based on the pilot’s initial report and a subsequent discussion that AARO held with the pilot to seek additional details about the pilot’s observation of the reported object.
All-domain Anomaly Resolution Office U.S. Department of Defense (U) Case: “Eg...
All-domain Anomaly Resolution Office U.S. Department of Defense (U) Case: “Eg...
Sérgio Sacani
M.pharm Pharmaceutics 2nd sem. introduction to Pulmonary drug delivery system, mechanism, Aersools, and aerosol parts barriers, physiological properties, preparation methods, evaluation parameters, advantages and diadvantages.
Pulmonary drug delivery system M.pharm -2nd sem P'ceutics
Pulmonary drug delivery system M.pharm -2nd sem P'ceutics
sakshisoni2385
This Presentation provide all information about 'Forensic Biology and it's biological Significance ' Forensic Biology is the application of concepts and procedures used in the biological sciences, typically in a medico-legal context. Forensic biologists analyze cellular and tissue samples, as well as physiological fluids that are relevant to a legal investigation.
Forensic Biology & Its biological significance.pdf
Forensic Biology & Its biological significance.pdf
rohankumarsinghrore1
HotJupiters are amongthebest-studied exoplanets, but it is still poorly understood how their chemical composition and cloud properties vary with longitude. Theoretical models predict that clouds may condense on the nightside and that molecular abundances can be driven out of equilibrium by zonal winds. Here we report a phase-resolved emission spectrum of the hot Jupiter WASP-43b measured from 5–12µ 5–12µ 5–12µm with JWST’s Mid-Infrared Instrument (MIRI). 1524 ±35 1524 ±35 and 863±23 The spectra reveal a large day–night temperature contrast (with average brightness temperatures of 1524 ± 35 863 ±23 863 ±23Kelvin, respectively) and evidence for water absorption at all orbital phases. Comparisons with three-dimensional atmospheric models show that both the phase curve shape and emission spectra strongly suggest the presence of nightside clouds which become optically thick to thermal emission at pressures greater than ∼100mbar. The dayside is consistent with a cloudless atmosphere above the mid-infrared photosphere. Con3trary to expectations from equilibrium chemistry but consistent with disequilibrium kinetics models, methane is not detected on the nightside (2σ upper limit of 1–6 parts per million, depending on model assumptions).
Nightside clouds and disequilibrium chemistry on the hot Jupiter WASP-43b
Nightside clouds and disequilibrium chemistry on the hot Jupiter WASP-43b
Sérgio Sacani
This presentation delivers about Physiochemical properties of nanomaterials and its nanotoxicity.
Physiochemical properties of nanomaterials and its nanotoxicity.pptx
Physiochemical properties of nanomaterials and its nanotoxicity.pptx
AArockiyaNisha
Ppt about green chemistry , sustainable chemistry , sustainable development , reactions in sustainable development, organic synthesis via green chemistry and sustainable development.
Green chemistry and Sustainable development.pptx
Green chemistry and Sustainable development.pptx
RajatChauhan518211
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GBSN - Biochemistry (Unit 1)
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fundamental of entomology all in one topics of entomology
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VIRUSES structure and classification ppt by Dr.Prince C P
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Botany krishna series 2nd semester Only Mcq type questions
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Natural Polymer Based Nanomaterials
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The Philosophy of Science
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b
Hubble Asteroid Hunter III. Physical properties of newly found asteroids
Hubble Asteroid Hunter III. Physical properties of newly found asteroids
GBSN - Microbiology (Unit 2)
GBSN - Microbiology (Unit 2)
All-domain Anomaly Resolution Office U.S. Department of Defense (U) Case: “Eg...
All-domain Anomaly Resolution Office U.S. Department of Defense (U) Case: “Eg...
Pulmonary drug delivery system M.pharm -2nd sem P'ceutics
Pulmonary drug delivery system M.pharm -2nd sem P'ceutics
Forensic Biology & Its biological significance.pdf
Forensic Biology & Its biological significance.pdf
Nightside clouds and disequilibrium chemistry on the hot Jupiter WASP-43b
Nightside clouds and disequilibrium chemistry on the hot Jupiter WASP-43b
Physiochemical properties of nanomaterials and its nanotoxicity.pptx
Physiochemical properties of nanomaterials and its nanotoxicity.pptx
Green chemistry and Sustainable development.pptx
Green chemistry and Sustainable development.pptx
Medical bioinformatics: Current trends, industry needs, and core competencies
1.
Medical bioinformatics Current trends,
industry needs, and core competences Lars Juhl Jensen
2.
3.
Ph.D.
4.
5.
postdoc
6.
staff scientist
7.
group leader
8.
9.
cofounder
10.
11.
current trends
12.
compressive genomics
13.
next generation sequencing
14.
scaling challenge
15.
Loh et al.,
Nature Biotechnology, 2012
16.
exponential cost increase
17.
store only differences
18.
work on compressed
data
19.
sublinear scaling
20.
new algorithms needed
21.
network biology
22.
beyond pathways
23.
24.
no discoveries
25.
protein networks
26.
STRING
27.
Franceschini et al.,
Nucleic Acids Research, 2013
28.
regulation
29.
cell cycle
30.
de Lichtenberg, Jensen
et al., Science, 2005
31.
disease phenotypes
32.
heart development
33.
Lage et al.,
Molecular Systems Biology, 2010
34.
diabetes
35.
Bergholdt et al.,
Diabetes, 2013
36.
applied text mining
37.
biomedical literature
38.
>10 km
39.
too much to
read
40.
full-text articles
41.
electronic health records
42.
structured data
43.
Jensen et al.,
Nature Reviews Genetics, 2012
44.
unstructured data
45.
46.
temporal correlations
47.
diagnosis trajectories
48.
Jensen et al.,
submitted, 2013
49.
adverse drug reactions
50.
Eriksson et al.,
submitted, 2013
51.
industry needs
52.
goals
53.
biomarker discovery
54.
target discovery
55.
ADR prediction
56.
data sources
57.
in-house data
58.
expression profiles
59.
screening assays
60.
security
61.
legal agreements
62.
poorly standardized
63.
public data
64.
expression profiles
65.
interaction networks
66.
literature
67.
unawareness
68.
patient data
69.
security
70.
privacy
71.
core competencies
72.
biological data mining
73.
quantity is not
the problem
74.
many data types
75.
different formats
76.
different identifiers
77.
different quality
78.
scripting language
79.
biological understanding
80.
statistical mindset
81.
medical text mining
82.
free text
83.
in Norwegian
84.
by busy doctors
85.
text-mining techniques
86.
information extraction
87.
named entity recognition
88.
dictionary construction
89.
medical knowledge
90.
speak Norwegian
91.
summary
92.
custom solution
93.
no standard software
94.
interdisciplinary team
95.
outsourcing
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