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Modeling the dynamic assembly of cell cycle complexes from high-throughput data
1. Lars Juhl Jensen EMBL Heidelberg Modeling the dynamic assembly of cell cycle complexes from high-throughput data
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3. Getting the parts list Yeast culture Microarrays Gene expression Expression profile Cho & Spellman et al. 600 periodically expressed genes (with associated peak times) that encode “dynamic proteins” The parts list New analysis
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5. Extracting a cell cycle interaction network Cell cycle microarray data Physical PPI interactions with confidence scores Expand the set of proteins to include non-periodic proteins that are strongly connected to periodic proteins Raw Data Node selection List of periodically expressed proteins with peak time Interactions Require compatible compartments and high confidence Extract cell cycle network