SlideShare une entreprise Scribd logo

Network medicine - Integrating drugs, targets, diseases and side-effects

•Télécharger en tant que PPT, PDF•
•
Lars Juhl Jensen
Lars Juhl Jensen

LEO Pharma, Ballerup, Denmark, November 5, 2008

Santé & MédecineTechnologie
1  sur  115
Lars Juhl Jensen Network medicine Integrating drugs, targets, diseases and side-effects
Lars Juhl Jensen Network medicine Integrating drugs, targets, diseases and side-effects
Lars Juhl Jensen Network medicine Integrating drugs, targets, diseases and side-effects
 
 
what went wrong?
phase 0
before you do anything
a good problem
a good idea
dynamics of complexes
microarray data
protein interactions
de Lichtenberg, Jensen, et al., Science , 2005
phosphorylation networks
mass spectrometry data
sequence motifs
functional associations
Linding, Jensen, Ostheimer et al., Cell , 2007
Linding, Jensen, Ostheimer et al., Cell , 2007
the problem
new uses for old drugs
drug–drug network
shared target(s)
chemical similarity
Tanimoto coefficients
 
 
similar drugs share targets
only trivial predictions
the idea
chemical perturbations
phenotypic readouts
drug treatment
side effects
the implementation
information on side effects
package inserts
 
text mining
side-effect ontology
backtracking
 
side-effect correlations
 
GSC weighting
side-effect frequencies
 
raw similarity score
 
p-values
 
side-effect similarity
chemical similarity
 
reference set
drug–target pairs
 
drug–drug pairs
score bins
benchmark
 
fit calibration function
 
probabilistic scores
the results
drug–drug network
ATC codes
 
categorization
 
 
 
map onto score space
 
the experiments
20 drug–drug relations
in vitro binding assays
 
 
 
K i <10 µM for 11 of 20
cell assays
9 of 9 showed activity
 
the big picture
STITCH
 
protein–chemical network
 
primary experimental data
activity screens
Fedorov et al., PNAS , 2007
protein interactions
Jensen & Bork, Science , 2008
gene coexpression
 
genomic context
Korbel et al., Nature Biotechnology , 2004
literature mining
 
curated knowledge
Letunic & Bork, Trends in Biochemical Sciences , 2008
different formats
different identifiers
different reliability
benchmarking
von Mering et al., Nucleic Acids Research , 2005
373 genomes
Jensen et al., Nucleic Acids Research , 2008
transfer by orthology
combine all evidence
 
Acknowledgments ,[object Object],[object Object],[object Object],[object Object],[object Object]
http://larsjuhljensen.wordpress.com

Recommandé

Using side effects for drug target identification
Using side effects for drug target identificationUsing side effects for drug target identification
Using side effects for drug target identificationLars Juhl Jensen
 
Text and data mining
Text and data miningText and data mining
Text and data miningLars Juhl Jensen
 
The Gnome's Guide to Data Integration
The Gnome's Guide to Data IntegrationThe Gnome's Guide to Data Integration
The Gnome's Guide to Data IntegrationLars Juhl Jensen
 
Making the best of a bad situation: Using side effects to reveal new targets ...
Making the best of a bad situation: Using side effects to reveal new targets ...Making the best of a bad situation: Using side effects to reveal new targets ...
Making the best of a bad situation: Using side effects to reveal new targets ...Lars Juhl Jensen
 
STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...Lars Juhl Jensen
 
Personalized models for Quantitative Systems Pharmacology
Personalized models for Quantitative Systems PharmacologyPersonalized models for Quantitative Systems Pharmacology
Personalized models for Quantitative Systems PharmacologyRutgers University
 
tarGET iD
tarGET iDtarGET iD
tarGET iDJan Vomacka
 
59832462
5983246259832462
59832462Gerifalte Ns
 

Recommandé

Using side effects for drug target identification
Using side effects for drug target identificationUsing side effects for drug target identification
Using side effects for drug target identificationLars Juhl Jensen
 
Text and data mining
Text and data miningText and data mining
Text and data miningLars Juhl Jensen
 
The Gnome's Guide to Data Integration
The Gnome's Guide to Data IntegrationThe Gnome's Guide to Data Integration
The Gnome's Guide to Data IntegrationLars Juhl Jensen
 
Making the best of a bad situation: Using side effects to reveal new targets ...
Making the best of a bad situation: Using side effects to reveal new targets ...Making the best of a bad situation: Using side effects to reveal new targets ...
Making the best of a bad situation: Using side effects to reveal new targets ...Lars Juhl Jensen
 
STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...Lars Juhl Jensen
 
Personalized models for Quantitative Systems Pharmacology
Personalized models for Quantitative Systems PharmacologyPersonalized models for Quantitative Systems Pharmacology
Personalized models for Quantitative Systems PharmacologyRutgers University
 
tarGET iD
tarGET iDtarGET iD
tarGET iDJan Vomacka
 
59832462
5983246259832462
59832462Gerifalte Ns
 
Computational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioningComputational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioningLars Juhl Jensen
 
Network biology: Large-scale biomedical data and text mining
Network biology: Large-scale biomedical data and text miningNetwork biology: Large-scale biomedical data and text mining
Network biology: Large-scale biomedical data and text miningLars Juhl Jensen
 
Network biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningNetwork biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningLars Juhl Jensen
 
Data integration: The STITCH database of protein-small molecule interactions
Data integration: The STITCH database of protein-small molecule interactionsData integration: The STITCH database of protein-small molecule interactions
Data integration: The STITCH database of protein-small molecule interactionsLars Juhl Jensen
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and textLars Juhl Jensen
 
Large-scale biomedical data and text integration
Large-scale biomedical data and text integrationLarge-scale biomedical data and text integration
Large-scale biomedical data and text integrationLars Juhl Jensen
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous dataLars Juhl Jensen
 
Prediction of protein-small molecule networks through large-scale data integr...
Prediction of protein-small molecule networks through large-scale data integr...Prediction of protein-small molecule networks through large-scale data integr...
Prediction of protein-small molecule networks through large-scale data integr...Lars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningLars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningLars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningLars Juhl Jensen
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseasesLars Juhl Jensen
 
Data Integration and Systems Biology
Data Integration and Systems BiologyData Integration and Systems Biology
Data Integration and Systems BiologyLars Juhl Jensen
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseasesLars Juhl Jensen
 
Cellular Network Biology
Cellular Network BiologyCellular Network Biology
Cellular Network BiologyLars Juhl Jensen
 
Data and Text Mining
Data and Text MiningData and Text Mining
Data and Text MiningLars Juhl Jensen
 
Data integration: The STITCH database of protein–small molecule interactions
Data integration: The STITCH database of protein–small molecule interactionsData integration: The STITCH database of protein–small molecule interactions
Data integration: The STITCH database of protein–small molecule interactionsLars Juhl Jensen
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and textLars Juhl Jensen
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and textLars Juhl Jensen
 
Unraveling signaling networks by data integration
Unraveling signaling networks by data integrationUnraveling signaling networks by data integration
Unraveling signaling networks by data integrationLars Juhl Jensen
 
One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...Lars Juhl Jensen
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineLars Juhl Jensen
 

Contenu connexe

Similaire à Network medicine - Integrating drugs, targets, diseases and side-effects

Computational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioningComputational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioningLars Juhl Jensen
 
Network biology: Large-scale biomedical data and text mining
Network biology: Large-scale biomedical data and text miningNetwork biology: Large-scale biomedical data and text mining
Network biology: Large-scale biomedical data and text miningLars Juhl Jensen
 
Network biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningNetwork biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningLars Juhl Jensen
 
Data integration: The STITCH database of protein-small molecule interactions
Data integration: The STITCH database of protein-small molecule interactionsData integration: The STITCH database of protein-small molecule interactions
Data integration: The STITCH database of protein-small molecule interactionsLars Juhl Jensen
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and textLars Juhl Jensen
 
Large-scale biomedical data and text integration
Large-scale biomedical data and text integrationLarge-scale biomedical data and text integration
Large-scale biomedical data and text integrationLars Juhl Jensen
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous dataLars Juhl Jensen
 
Prediction of protein-small molecule networks through large-scale data integr...
Prediction of protein-small molecule networks through large-scale data integr...Prediction of protein-small molecule networks through large-scale data integr...
Prediction of protein-small molecule networks through large-scale data integr...Lars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningLars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningLars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningLars Juhl Jensen
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseasesLars Juhl Jensen
 
Data Integration and Systems Biology
Data Integration and Systems BiologyData Integration and Systems Biology
Data Integration and Systems BiologyLars Juhl Jensen
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseasesLars Juhl Jensen
 
Data integration: The STITCH database of protein–small molecule interactions
Data integration: The STITCH database of protein–small molecule interactionsData integration: The STITCH database of protein–small molecule interactions
Data integration: The STITCH database of protein–small molecule interactionsLars Juhl Jensen
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and textLars Juhl Jensen
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and textLars Juhl Jensen
 
Unraveling signaling networks by data integration
Unraveling signaling networks by data integrationUnraveling signaling networks by data integration
Unraveling signaling networks by data integrationLars Juhl Jensen
 

Similaire à Network medicine - Integrating drugs, targets, diseases and side-effects (20)

Computational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioningComputational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioning
 
Network biology: Large-scale biomedical data and text mining
Network biology: Large-scale biomedical data and text miningNetwork biology: Large-scale biomedical data and text mining
Network biology: Large-scale biomedical data and text mining
 
Network biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningNetwork biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data mining
 
Data integration: The STITCH database of protein-small molecule interactions
Data integration: The STITCH database of protein-small molecule interactionsData integration: The STITCH database of protein-small molecule interactions
Data integration: The STITCH database of protein-small molecule interactions
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and text
 
Large-scale biomedical data and text integration
Large-scale biomedical data and text integrationLarge-scale biomedical data and text integration
Large-scale biomedical data and text integration
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous data
 
Prediction of protein-small molecule networks through large-scale data integr...
Prediction of protein-small molecule networks through large-scale data integr...Prediction of protein-small molecule networks through large-scale data integr...
Prediction of protein-small molecule networks through large-scale data integr...
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseases
 
Data Integration and Systems Biology
Data Integration and Systems BiologyData Integration and Systems Biology
Data Integration and Systems Biology
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseases
 
Cellular Network Biology
Cellular Network BiologyCellular Network Biology
Cellular Network Biology
 
Data and Text Mining
Data and Text MiningData and Text Mining
Data and Text Mining
 
Data integration: The STITCH database of protein–small molecule interactions
Data integration: The STITCH database of protein–small molecule interactionsData integration: The STITCH database of protein–small molecule interactions
Data integration: The STITCH database of protein–small molecule interactions
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and text
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and text
 
Unraveling signaling networks by data integration
Unraveling signaling networks by data integrationUnraveling signaling networks by data integration
Unraveling signaling networks by data integration
 

Plus de Lars Juhl Jensen

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...Lars Juhl Jensen
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineLars Juhl Jensen
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationLars Juhl Jensen
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeLars Juhl Jensen
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataSTRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataLars Juhl Jensen
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textLars Juhl Jensen
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Lars Juhl Jensen
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeLars Juhl Jensen
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Lars Juhl Jensen
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataLars Juhl Jensen
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionLars Juhl Jensen
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationLars Juhl Jensen
 
The Art of Counting: Scoring and ranking co-occurrences in literature
The Art of Counting: Scoring and ranking co-occurrences in literatureThe Art of Counting: Scoring and ranking co-occurrences in literature
The Art of Counting: Scoring and ranking co-occurrences in literatureLars Juhl Jensen
 

Plus de Lars Juhl Jensen (20)

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicine
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotation
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using Cytoscape
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataSTRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous data
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured text
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and Cytoscape
 
Cellular networks
Cellular networksCellular networks
Cellular networks
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and text
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous data
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognition
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and text
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactions
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactions
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritization
 
The Art of Counting: Scoring and ranking co-occurrences in literature
The Art of Counting: Scoring and ranking co-occurrences in literatureThe Art of Counting: Scoring and ranking co-occurrences in literature
The Art of Counting: Scoring and ranking co-occurrences in literature
 

Dernier

Lucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel roomLucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel roomdiscovermytutordmt
 
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...Taniya Sharma
 
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Servicemakika9823
 
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...indiancallgirl4rent
 
Call Girls Nagpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Nagpur Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Nagpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Nagpur Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service KochiLow Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service KochiSuhani Kapoor
 
Chandrapur Call girls 8617370543 Provides all area service COD available
Chandrapur Call girls 8617370543 Provides all area service COD availableChandrapur Call girls 8617370543 Provides all area service COD available
Chandrapur Call girls 8617370543 Provides all area service COD availableDipal Arora
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...narwatsonia7
 
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...Taniya Sharma
 
Call Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service Coimbatore
Call Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service CoimbatoreCall Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service Coimbatore
Call Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service Coimbatorenarwatsonia7
 
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore EscortsCall Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escortsvidya singh
 
Call Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...Arohi Goyal
 
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual NeedsBangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual NeedsGfnyt
 
Call Girls Kochi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Kochi Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Kochi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Kochi Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...astropune
 
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...jageshsingh5554
 

Dernier (20)

Lucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel roomLucknow Call girls - 8800925952 - 24x7 service with hotel room
Lucknow Call girls - 8800925952 - 24x7 service with hotel room
 
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
 
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
 
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
 
Call Girls Nagpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Nagpur Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Nagpur Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Nagpur Just Call 9907093804 Top Class Call Girl Service Available
 
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service KochiLow Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
Low Rate Call Girls Kochi Anika 8250192130 Independent Escort Service Kochi
 
Chandrapur Call girls 8617370543 Provides all area service COD available
Chandrapur Call girls 8617370543 Provides all area service COD availableChandrapur Call girls 8617370543 Provides all area service COD available
Chandrapur Call girls 8617370543 Provides all area service COD available
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
 
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
 
Call Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service Coimbatore
Call Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service CoimbatoreCall Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service Coimbatore
Call Girl Coimbatore Prisha☎️ 8250192130 Independent Escort Service Coimbatore
 
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore EscortsCall Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
 
Call Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Aurangabad Just Call 9907093804 Top Class Call Girl Service Available
 
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
 
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCREscort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
 
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual NeedsBangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
Bangalore Call Girl Whatsapp Number 100% Complete Your Sexual Needs
 
Call Girls Kochi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Kochi Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Kochi Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Kochi Just Call 9907093804 Top Class Call Girl Service Available
 
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
 
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
 
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
 
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
 

Network medicine - Integrating drugs, targets, diseases and side-effects