Collagen in the treatment of rheumatic diseases

4. Healthy joint

5. OA changes in the joint

7. Collagens Collagens are the widespread structural components of extracellular matrices of connective tissues such as: tendons, ligaments, bones, skin and others. The common sign of collagens is the triple helix structure (  - helix) in molecule .

8. Occurrence of collagen type I  and II  in human body . Tendon  Bone  Skin  Dental mass  Ligaments  Blood vessel  Cartilage  (  only in OA ) Intervertebral discs   Vitreous humor of the eye  50% of collagen in body is present in bones

10. The low doses of native collagen type II applied repeatedly to rats orally (3  g/rat) before immunization resulted in inhibit ion of collagen-induced arthritis and also adjuvant induced arthritis. Similar effects were observed by fragments of collagen II, synthetic peptides of collagen and collagen type I . Thompson,HSG,Staines,NA. Clin Exp Immunol, 1985;64:581-6 Experimental studies with collagens (animal models)

19. Open trial with Colafit 2 OA of knee III. 1 OA of knee II. 0 OA of knee I. 4 OA of hip III. 7 OA of hip II. 6 OA of hip I. 54.6 ( 39-72) Mean age 16 Number of w o men 4 Number of men 20 Number of pa t ients

20. p<0,0005 p<0,005

21. Questionnaire for Colafit Age............(years) I have joint difficulties since...... (year / month) With similar problems suffer (suffered) in family (e.g. parents, sister): ................................................................. ................................................................. I am visiting physician with my joint difficulties: Yes□ No□ Specialisation of my physician is:.................................................... Diagnosis made by physician:.......................................................... Fill your name and adress: Name and surname:....................................................... Adress:.................................................................. City and postal code:............................................................ The aim of this project is to increase the quality of life of patients suffering from osteoarthritis and other joint diseases. Thank you for your help and cooperation. 1- spine / back 2- upper extremities joints 3- hip joints 4- knee joints 5- ankles Left side Right side Duration of treatment: Dosage (tablets/day): Name of medication : The medication used because of pain during the last 2 months: Duration of treatment : Dosage (tablets/day) : Name of medication : The name of medications used because of joint difficulties during the last 2 months:

23. ( No . pac. 152)

24. ( No. of patients 167)

25. (No. of patients 177)

26. (No. of patients 197)

27. (No. of patients 121)

28. (No. of patients . 139)

29. Tenders Nails Hair Skin Joints Bones Colafit Tissues where Colafit can help:

39. Modified Rodnan skin index

41. Thank you for your attention!