1. SUBCUTANEOUS MYCOSES
grow on soil or on decaying vegetation
must be introduced into subcutaneous tissue in
order to produce disease
GENERALLY : lesions spread slowly from the area
of implantation
extension via lymphatics draining the lesion is
slow (except in sporotrichosis)
Thursday, January 19, 2012
2. SPOROTHRIX SCHENCKII
dimorphic
live on plants or wood
causes sporotrichosis
chronic
granulomatous
infection
Thursday, January 19, 2012
3. SPOROTHRIX SCHENCKII
DIAGNOSTICS:
pus or biopsy from lesions as
specimens
culture on Saboraud’s with
clusters of conidia =
diagnostic
converts to yeast form at 37C
agglutination of yeast cell
from sera = not diagnostic
Thursday, January 19, 2012
4. SPOROTHRIX SCHENCKII
TREATMENT:
self-limited though chronic
potassium iodide
administered orally for
weeks
ampothericin B
intravenously
oral ketoconazole
Thursday, January 19, 2012
5. CHROMOBLASTOMYCOSIS
(Chomomycosis)
slowly progressive granulomatous
infection of skin
caused by black molds
Phialophora verrucosa, Fonsecaea pedrosoi,
Rhinocladiella aquaspersa, Cladosporium
carrionii
Thursday, January 19, 2012
10. CHROMOBLASTOMYCOSIS
(Chomomycosis)
DIAGNOSTICS:
specimen: scrapings or
biopsy from lesions
microscopy: scrapings in 10%
potassium hydroxide (dark,
round fungus cells = sclerotic
bodies diagnostic)
culture in Saboraud’s and
digests gelatin
Thursday, January 19, 2012
11. CHROMOBLASTOMYCOSIS
(Chomomycosis)
TREATMENT:
surgical excision with wide
margins for small lesions
chemotherapy with flucytosine
or itraconazole for larger
lesions
locally applied heat may be
beneficial
relapse common
Thursday, January 19, 2012
