At the humanity plus summit at the Harvard Science Center Cambridge I will deliver this presentation entitled HACCP as Lifespan Extension Managment System. Integration of the science with a globally accepted systems management system HACCP may enable the industry of life and health extension to grow into a self-directed personalized mass market. To do this the system must be able to overcome moral hazard hazards more daunting than science historically speaking. A single open source accessible health record isthe product of this system. An operating system of the scale of Windows can deliver the goods. Universally accessible extreme lifespan and healthspan.

1. HACCP AS A LIFESPAN EXTENSION MANAGEMENT SYSTEM
“Empowering
Self-Directed Health-span/Life-span Extension”
Presented to 2010 Humanity+ Summit
June 12–13 2010, Harvard University
Presented by Morris Johnson
“CITIZEN-SCIENTIST”
CTO OF PHARMA INC.
Box 33, Road 707 S, Beaubier, Sk., Ca., S0C-0H0
Canterpene (at) gmail.com, 701-240-9411, 306-447-4944

2. What is HACCP?
Developed by Pillsbury for NASA to provide food safety while reducing
dependence on finished product sampling and testing
The HACCP (Hazard Analysis Critical Control Points) system gives value to food
and pharma by ensuring a safe high quality finished product
Adopted worldwide for
food/pharma safety in 1980's
Key Element is:
Preventative Control by managing
Critical Control Points (CCPs)

3. The HACCP 12 step life-cycle
Manages 5 Key aspects of medical practice:
“PRECP”
1-Preventative
2-Regenerative
3-Enhancement
4-Crisis management
5-Palliative

4. The overarching hazard reduction Safety system is supported by quality and
efficiency QA/QC management practices:
1- Six-Sigma - Quality Improvement , error correction cycle
DMAIC (Define, Measure, Analyse,Improve ,Control )
In food and Pharma Six-Sigma
strives to keep quality errors
under 6 per 1 million transactions
2- LEAN -(elimination of waste and
the reduction of variation
found within processes
physical and human resources,
Knowledge and Information
“Open source access” to all published research is a key QA/QC tool

5. STEP-1/12-Assemble HACCP team
Individual/ You are your own
HACCP Coordinator (HC)
Primary care Physician,
Additional health services providers
as required

6. STEP-2/12-Describe product and process
Your:
Statistics e.g. age/gender
Health history
Family history
Personalization :
to describe you
as a biological program:
Genomic profiling e.g “23 and me”
Metabolomic profiling
Microbiomic profiling
Biomarker profiling
e.g. inflammatory and oxidative
Your bio-hard drive gets a “Norton”.

7. STEP-3/12-Identify intended use
What life stage are you at:
Infancy
Childhood
Youth
Adulthood,
Mid-life
Old-age
What do you plan to do with your life
…this will determine the aggressiveness
with which to apply the succeeding steps.

8. STEP-4/12-Detail a Plant Schematic diagram,
Design a process flow Diagram; Manage incoming Materials
The inputs will be from all of the 6 hazard analysis pre-requisite domains:
1-Nutrigenomics 2-Metabolomics
3-Microbiomics 4-Environomics
5-Epigenomics 6-Psychomics
/Transcriptomics
Relate the inputs/timing/combination to cell/tissue/organ and whole body function

9. STEP-5/12- Do On-site Verification
of flow diagram and Plant schematic
Here you relate step 4
with steps 2 and 3
to look for conflicts
…this is where
you personalize everything

10. STEP-6/12-Do Hazard Analysis
Initial HACCP Hazard Analysis Pre-requisites Risk Analyses are completed
before a plan is deemed operational
Update annually or when a significant event or a number of minor events occur.
Your plan must be do-able “say what you do, do what you say”.
To complete a hazard analysis:
Define Hazard and how to address it ; Who will complete hazard mitigation,
Frequency for review ; Deviation Procedure, and corrective/preventative
measures; Verification and Validation that the method used is appropriate and
effective
Record the cycle of events Then detail the management of the data/records
HACCP is not paper bound…e-health and health data management technology
make this user friendly on the interface side…technology will render it invisible.
Like Windows, mac or linux or unix
This is an Operating System …. for your biological program and sub-routines

11. STEP-7/12-Critical Control Point Determination:
(CCPs)
Aubrey de Grey‟s 7 deadly sins of biology (SENS):
1-Junk inside cells,
2 Junk outside cells ,
3-Too few cells,
4-Too many cells,
5-Chromasome mutations ,
6-Mitochondrial mutations,
7-Protein cross-links,
I would like to suggest perhaps 2 more:
8 Regulatory mutations (centriole and chromatin) ;
9 Intra phagocytic metagenomic microbiota (Metagenome), a distributed biofilm

12. STEP-8/12-Set Critical Limits
to which the hazards can and will be reduced
The limits to which for example degenerative metabolic biological pathways
e.g. inflammation, oxidative stress, metabolic syndromes and derivative
pathology can be controlled are science driven but modified by external non-
biological Moral Hazards"the punishment we get for doing good deeds"
or as the cartoon character Ogo Pogo said “we has seen the enemy and they is us”.

13. STEP-9/12-Monitoring Procedures
Technology from interactive swarms of nanobots to smart devices ..the industry,
infrastructure , software and hardware welcome 7 billion customers.
http://singularityhub.com/2010/04/28/delivering-babies-treating-heart-attacks-
scanning-brains-all-from-your-phone/
http://www.mdpi.com/1660-4601/6/2/492 - Patient-Driven Health Care Models
Fully fledged integration of HACCP with e-health data and
narrow AGI will render this function invisible.
HACCP methodology simplifies integration of structure and function.
Convergence of monitoring technology form and function:
e.g. E-health monitoring clothes, and jewelry
Security and policing are enabled so there must be deregulation of what we call
social crimes such as soft drug use or consumers will not accept the intrusive and
pervasive health technologies.

14. STEP-10/12-Establish Deviations and
Corrective/preventative measures (CPM) for each hazard and create a Recall Plan
How much can you control
given the technology and resources you personally have to work with
.
CPM are focal to HACCP…
It is this aspect that originally led me to the concept
of something I first called
“HACCP for Humans”
AKA-
Advanced Regenerative Lifespan Augmentation
“ARLA”

15. STEP-11/12-Verification Procedures
Verification that what you have done has sufficiently controlled the hazard.
This is lockstep with validation that the procedure(s) you have chosen are
operating as originally designed or intended
Perhaps the major regulatory bodies will morph to oversee these functions with
increasing assistance from emerging AGI technologies.

16. STEP-12/12-Record Keeping/Document storage
and management and Audits
System wide e-health data mining is essential to optimize outcomes
Keeping 7billion biological programs running asynchronously in parallel without
crashing would be a really good entry level management job for an AGI
(Artificial General Intelligence)
http://singularityhub.com/2010/05/10/the-ai-doctor-is-ready-to-see-you/
Managing all risks at CCP‟s within the 5 domains of medicine
while designing / running simulations and hot-patching bio-code
Would make an AGI happier than a pig in shit

17. RECALL PLAN
Defective product has to be reworked or disposed of
PALLIATION and a funeral vs CRYONICS or/and ENCHANCMENT
Cryonic Stasis is limited by regulatory and legal factors preventing it from
intervening before extreme levels of biological degeneration have run their course
(death)
21st C enhancement factors increase our robustness presents a new economic
paradigm.
The capacity to make life and health more valuable than death , in the
marketplace is pivotal to the success of “HACCP 4 ARLA”..
It is no longer sustainable to grow and educate 7 billion plus humans for 25
years, extract 35 years of work and then dispose of their wealth and intellectual
capital over a final 20 years.
The economics of adding indeterminate periods of work , re-education , and
leisure to pay for lifespan and healthspan extension services creates the new
aspect to the recall plan…re-work.is first step towards biological
enhancement/self-directed evolution.

18. Audit/ Periodic Revision
The user defines the sophistication of a self-or third party audit plan
Each audit cycle leads to improved levels of process control,
improved monitoring, verification and validation methods
Morphing a government and bureaucrat centric status quo to an open sourced one
with just
“Me and my AGI enabled agent”
Is both a challenge and a business opportunity.
Commercializing an operating system and bootstrapping it just like Gates did
starting with Windows 2.0, but doing it with a Linux style collaborative style
As Christine Petersen once said
“you with all your good science needs me the token commercialization person”

19. The Pre-requisite management domains to utilize HACCP for Human Health
Management
Each of 6 „omics domains operates on different levels on a time scale. Each
succeeding level has a composition requiring a longer time scale for action with a
higher capacity for residual persistence.
Initially there are 6 pre-requisite domains. Bullets can be added to each
as system audits justify them.
For Example
in the food safety HACCP system in Canada
we have 6 domains and 72 bullets in total.

20. 1-Nutrigenomics
All molecules small and large can act singly or together to drive the other „Omics.
There is no distinction between foods, supplements and pharmaceuticals..
They just have different temporal and activity coefficients
Simply put there are 2 sets of inverse relationships. Food on one end predominates
the second-to-second base metabolism required for survival. Small amounts of
micronutrients effect the mid and long term „omics loops
Pharma and toxins are on the far end of the spectrum.
e.g. http://en.wikipedia.org/wiki/Marshall_Protocol

21. 2-Metabolomics
The management of “stable” metabolic feedback loops
Many think of these now as limited to
things like pre-diabetes, inflammatory
or plaque driving processes.
As the preventative, regenerative and enhancement aspects of medicine
become more well developed a deeper understanding of the
metabolic feedback loops driving metabolomics
will be generated then managed in an ever more predictable fashion.
http://www.rdmag.com/News/2010/04/Life-Science-Genomics-Metabolic-
fingerprints-offer-path-toward-personalized-medicine/

22. 3-Microbiomics
Microbiomes can up/down regulate
A distributed biofilm with metabolomic , epigenomic and nutrigenomic functions.
Ethno-Endogenous Microbiomes
Exogenous Microbiomes- range from herpes to synthetic organisms such as
nanobots , stem cells or respirocytes and will include genetically altered microbes
which purposefully and predicatably re-write core genomics.
DIY microbiomes…????
Safer than genomic modification;
Components can be designed to be
removable or
exchanged/upgraded

23. 4-Environomics
Physical Stress Biological Stress
Chemical Stress Social Stress
5-Epigenomics/Transcriptomics - The Low Hanging Fruit
USA Patent Number 6541680
“Nutritional methyl supplements change
DNA methylation and related characteristics
of mammalian offspring ”
http://www.dailygalaxy.com/my_weblog/2010/05/
is-aging-an-accident-of-evolution-a-weekend-feature.html

24. 6-Psychomics- “managing moral hazards”
The biological Moral Hazard: the Placebo Effect
Non-biological Moral Hazards:
Political e. g. individual ownership of ones body VS State controls
Military e.g. Leon Kass‟s fear that long lived people would not fight wars
Economic e.g. hyperbaric hydrogen therapy VS Dismantling due to uninsurable liability
Legal e.g. hemp as a food&health supp VS narcotics law enforcement and power of illegal
economies who use law to maintain market monopoly
Regulatory e.g. common sense regulations VS mindless authority
http://www.genengnews.com/articles/chitem.aspx?aid=3200 or Dimethy-sulfoxide as a
“chemical needle” VS is unregulatable technology shunned and regulatorily persecuted
Theistic e.g. stem cells VS religious interpretations of sentience/soul
Social e.g. Dumbed down media VS Dr. OZ et. al.VS Social Media enabled collaboration
Cultural e.g. Neo-Luddite eco-terrorist bio-sabotage of GMO labs
Moral Hazards can decimate the successful operation of the entire plan
http://www.guardian.co.uk/commentisfree/2010/apr/15/transhumanism-biological-immortality

25. The net benefit , "The Longevity Dividend"
http://www.reuters.com/article/newsOne/idUSTRE6360LP20100407
Begs the question … Does the length of health-span and life-span we can expect
entirely depend upon making the value to the global economy of life more than
that of death?
You bet your life it does…….Yes.
Life insurance companies value a human life at 2 million.
Health plans converge at figure of 50,000 per quality adjusted life year. (QALY)
A combination of economics and science , QALY cost decides if a medical good or
service is worth doing immediately or if it should be rationed e.g. heroic critical
care efforts VS end of life cycle palliation.
Investment Decisions made by the pension and insurance industries are
CRITICAL
“Third Bridge” technologies with mass individualized commercialization will
require substantial capital investment
HACCP increases the value of the “longevity dividend” by reducing the cost of
QALYs so that lifespan and healthspan extension goods and services provide
sufficient return to society&capital to justify investment into the Economy of Life .

26. TAKE-HOME POINTS
HACCP, a robust management system with 30 years History of use is the logical
methodology to propel the concept of universally accessible extreme health-span
and life-span extension into mainstream adoptation
HACCP can manage moral hazards, which threaten to limit the rate of adoption of
Pro-Longevity technology by the global economy within a time frame short enough
to save the lives of the baby-boomer generation.
Simply put HACCP is the root/ core management system to deliver universally
accessible indefinite human lifespan within the functional lifespan of the baby
boomer generation.
Your body is the most valuable piece of property
you will ever own so manage it accordingly

27. HACCP method And system enable creation
Of Novel health records which capture Data
In a unique and comprehensive manner
so that it can be utilized as “open source”,
Compiled into databases, Analysed, mined
and yield the capacity for Individuals
to self-direct their own Robust
Lifespan/Healthspan Management program
in a Six-sigma and Lean manner.
Current systems do not empower you.>>>>
With HACCP “YOU” control everything.
“Product, Process, Premises, Personnel”.

28. “Aging and Death are Sacred Cows
but Sacred Cows make the best burgers!”
I‟d like to thank Alex Lightman for Inviting me
as well as my Sponsors: my Company shareholders & partners
http://hplusmagazine.com/articles/forever-young/hemp-victory-over-aging

29. Canterpene, a healthspan/lifespan extension product that has had to manage
moral hazardsAnd has converted a problem into a solution
Patent Pending 2,636,594- REGULATORY COMPLIANT METHOD TO GROW ,
HARVEST AND PRODUCE INDUSTRIAL MILLED HEMP SEED AND DERIVATIVE
FUNCTIONAL PRODUCTS FOR HUMAN AND VETERINARY USE

30. (This page reserved for a .jpg of our clinical trial which will be done by June 03)

31. Thank you….Questions?