Material Safety Data Sheet for Encapsome-CL the plain control liposome for Clodronate Encapsulated Liposome (Clodrosome)

1. ENCAPSULA NANOSCIENCES LLC
MATERIAL SAFETY DATA SHEET
Date Printed: 12/18/2011
Date Updated: 02/04/2006
Version 1.4
Section 1 - Product and Company Information
Product Name: PLAIN LIPOSOMES IN PHOSPHATE BUFFERED SALINE
Product Number: ENCP-2
Brand: ENCAPSOME®
Company Address: ENCAPSULA NANOSCIENCES LLC
441 DONELSON PIKE, SUITE 345
NASHVILLE, TN 37214, USA
Technical Phone: 615-884-4442
Fax: 615-250-8747
Emergency Phone: 615-438-8553
Section 2 - Composition/Information on Ingredient
Substance Name CAS# SARA313
PLAIN LIPOSOMES NONE No
Ingredient Name CAS # Percent SARA313
WATER 7732-18-5 >90 No
SODIUM CHLORIDE 7647-14-5 <5 No
POTASSIUM CHLORIDE 7447-40-7 <5 No
DISODIUM PHOSPHATE 7558-79-4 <5 No
POTASSIUM PHOSPHATE 7758-11-4 <5 No
L-α-PHOSPHATIDYLCHOLINE 8002-43-5 <5 No
CHOLESTEROL 57-88-5 <5 No
Section 3- Hazards Identification
HMIS RATING
HEALTH: 0
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 0
FLAMMABILITY: 0
REACTIVITY: 0
Potential Health Effects
Inhalation May be harmful if inhaled. May cause respiratory tract
irritation.
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Skin May be harmful if absorbed through skin. May cause skin irritation.
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2. ENCAPSULA NANOSCIENCES LLC
MATERIAL SAFETY DATA SHEET
Eyes May cause eye irritation.
Ingestion May be harmful if swallowed.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious amounts
of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
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HANDLING
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3. ENCAPSULA NANOSCIENCES LLC
MATERIAL SAFETY DATA SHEET
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing.
STORAGE
Suitable: Keep tightly closed under an inert gas. Store in refrigerator
at 4 °C.
Section 8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Respiratory protection is not required. Where protection is
desired, use multi-purpose combination (US) or type ABEK (EN
14387) respirator cartridges.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Appearance
White liquid dispersion
Safety data
pH
7.4
Melting point
N/A
Boiling point
N/A
Flash point
N/A
Ignition temperature
N/A
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Lower explosion limit
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4. ENCAPSULA NANOSCIENCES LLC
MATERIAL SAFETY DATA SHEET
N/A
Upper explosion limit
N/A
Water solubility
N/A
Section 10 - STABILITY AND REACTIVITY
Storage stability
Can be stored for one month under nitrogen or argon at 4 °C.
Materials to avoid
Strong acids, Strong bases
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon
oxides, Oxides of phosphorus, Hydrogen chloride gas, Sodium oxides
Section 11 - TOXICOLOGICAL INFORMATION
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Section 12 - ECOLOGICAL INFORMATION
Elimination information (persistence and degradability)
N/A
Ecotoxicity effects
N/A
Further information on ecology
N/A
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Section 13 - DISPOSAL CONSIDERATIONS
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5. ENCAPSULA NANOSCIENCES LLC
MATERIAL SAFETY DATA SHEET
Product
Observe all federal, state, and local environmental regulations.
Contaminated packaging
Dispose of as unused product.
Section 14- TRANSPORT INFORMATION
DOT (US)
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods
Section 15 - REGULATORY INFORMATION
OSHA Hazards
No OSHA HAZARD
DSL Status
All components of this product are on the Canadian DSL list.
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting
requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with
known CAS numbers that exceed the threshold (De Minimis) reporting levels
established by SARA Title III, Section 313.
SARA 311/312 Hazards
NO SARA HAZARD
Massachusetts Right To Know Components
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components
Lecithin AKA L-α-Phosphatidylcholine
CAS-No. 8002-43-5
Revision Date:
5
Cholesterol
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CAS-No. 55-88-5
Revision Date:
ENCAPSOME®-PBS WWW.CLODROSOME.COM

6. ENCAPSULA NANOSCIENCES LLC
MATERIAL SAFETY DATA SHEET
New Jersey Right To Know Components
Lecithin AKA L-α-Phosphatidylcholine
CAS-No. 8002-43-5
Cholesterol
CAS-No. 55-88-5
Revision Date:
California Prop. 65 Components
This product does not contain any chemicals known to State of California
to cause cancer, birth, or any other reproductive defects.
Section 16- OTHER INFORMATION
Further information
Copyright 2009 Encapsula NanoSciences LLC license granted to make
unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be
all inclusive and shall be used only as a guide. The information in this
document is based on the present state of our knowledge and is applicable
to the product with regard to appropriate safety precautions. It does not
represent any guarantee of the properties of the product. Encapsula
NanoSciences LLC shall not be held liable for any damage resulting from
handling or from contact with the above product.
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ENCAPSOME®-PBS WWW.CLODROSOME.COM