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Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
1. PRODUCT AND COMPANY IDENTIFICATION
Product name: SODIUM CARBONATE (Vial 2 of 3 of a kit)
Product Number: SC
Brand: DOXOSOME
TM
/IMMUNODOX
TM
Company Address: ENCAPSULA NANOSCIENCES LLC
6 CADILLAC DRIVE SUITE 245
BRENTWOOD, TN, 37027
Technical Phone: 615-884-4442
Fax: 615-250-8747
Emergency Phone: 615-438-8553
2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient Name CAS# Percent
WATER 7732-18-5 >90
SODIUM CARBONATE 497-19-8 <5
3. HAZARDS IDENTIFCATION
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
(Category 2A) Eye Irritant, H319
GHS LABEL ELEMENTS, INCLUDING PRECAUTIONARY STATEMENTS
Pictogram
Signal word: Warning
Hazard Statement
H319 Causes eye irritation
Eye Irrit. Eye Irritation
Precautionary Statements
P264 Wash skin thoroughly after use.
P280 Wear protective gear to cover hands, eyes, and face.
P305, P351, P338 If exposed to eyes: Rinse with water for several minutes. If wearing contacts, remove them
if possible and continue to rinse eyes thoroughly
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
P337, P313 If eye irritation persists seek medical attention
HMIS RATING
HEALTH HAZARDS: 2
FLAMMABILITY: 0
CHRONIC HEALTH HAZARDS:
PHYSICAL HAZARDS: 0
NFPA RATING
HEALTH HAZARD: 2
FLAMMABILTY: 0
REACTIVITY: 0
POTENTIAL HEALTH EFFECTS
Eyes Will cause eye irritation.
4. FIRST AID MEASURES
ORAL EXPOSURE
Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
oxygen. Consult a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious amounts of water. Contact a
physician.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.
Contact a physician.
5. FIRE FIGHTING MEASURES
FLAMMABILITY
Not flammable or combustible
EXTINGUISHING MEDIA
It is suitable to use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
SPECIAL PROCTECTIVE EQUIPMENT FOR FIRE-FIGHTERS
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and
eyes.
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
HAZARDOUS COMBUSTION PRODUCTS
Hazardous decomposition products formed under fire conditions. Carbon oxides, sodium oxides
6. ACCIDENTAL RELEASE MEASURES
METHODS FOR CLEANING UP
Absorb any spilled material quickly using absorbent pads. Apply bleach to the affected area and let
sit for several hours. Clean the affected area thoroughly with soap and water to remove the bleach.
Collect all clean up materials and dispose of them in accordance with local, state and federal waste
disposal laws.
ENVIRONMENTAL PRECAUTIONS
Do not let product enter drains. If safe to do so prevent further leakages or spills.
PERSONAL PRECAUTIONS
Use personal protective equipment. Avoid breathing in vapors, dust, mist or gas. Ensure adequate
ventilation. Prepare evacuation sites.
7. HANDLING AND STORAGE
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing. Wash hands
thoroughly after handling.
STORAGE
Suitable: Keep tightly container closed. Store in temperature between approximately 2-8
o
C. Do not
freeze. Product is sensitive to moisture and light.
8. EXPOSURE CONTROLS/ PERSONAL PROTECTION
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU). Where protection is desired, may use a respirator type
P95 (US) or P1 (EU EN 143) for higher level protection use OV/AG/P99 (US) or type ABEK-P2 (EU EN
143).
Hand: Compatible chemical-resistant gloves. Dispose of gloves with proper technique to avoid skin
contact. Recommended material is nitrile rubber with a thickness of 0.11mm.
Eye: Chemical safety goggles with side shades conforming to EN166 (EU) or NIOSH (US).
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
Skin and Body: Wear a complete suit protecting against chemicals.
GENERAL HYGIENE MEASURES
Wash hands thoroughly after handling. Wash contaminated clothing before reuse. Prepare all
materials under the fume hood and avoid generating aerosols.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
translucent
Safety data
pH 11.4
Melting point
N/A
Boiling point
N/A
Flash point
N/A
Ignition Temperature
N/A
Lower explosion limit
N/A
Upper Explosion limit
N/A
Water Solubility
Soluble
Density
N/A
10. STABILITY AND REACITIVITY
STORAGE STABILITY
Store under recommended conditions.
MATERIALS TO AVIOD
Strong acids
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous decomposition products formed under fire conditions- Carbon oxides, Sodium oxides
CONDITIONS TO AVOID
Exposure to moisture
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
11. TOXICOLOGICAL INFORMATION
CARCINOGENICITY
This product contains a component that has been reported to be carcinogenic based on its IARC,
OHSA, ACGIH, NTP, or EPA classification.
IARC: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the IARC.
OHSA: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the OHSA.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the EPA.
ACUTE TOXICITY
no data available
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation
Skin Absorption: no data available
Eye Contact: May Cause eye irritation
Inhalation: no data available
Ingestion: no data available
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
ADDITIONAL INFORMATION
RTECS: VZ4050000
burning sensation, cough, wheezing, laryngitis, shortness of breath, headache, nausea, vomiting
12. ECOLOGICAL INFORMATION
Elimination information (persistence and degradability)
N/A
Ecotoxicity effects
N/A
Further information on ecology
N/A
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
13. DISPOSAL CONSIDERATIONS
PRODUCT
Observe all federal, state, and local environment regulations. Contact a licensed professional waste
disposal service to remove this material.
CONTAMINATED PACKAGING
Dispose of as unused product.
14. TRANSPROT INFORMATION
DOT (US)
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods
15. REGULATORY INFORMATION
SARA 302 COMPONENTS
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title
III, Section 302
SARA 313 COMPONENTS
SARA 313: This material does not contain any chemical components with known CAS numbers
that exceed threshold (De Minimis) reporting levels established be SARA Title III, Section 313
SARA 311/312 HAZARDS
Acute health hazards
MASSACHUSETTS RIGHT TO KNOW COMPONENTS
No components are subject to the Massachusetts Right to Know Act
PENNSYVANIA RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
Sodium Carbonate 497-19-8
Water 7732-18-5
NEW JERSEY RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
Sodium Carbonate 497-19-8
Water 7732-18-5
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
CALIFORNIA PROP. 65 COMPONENTS
This product does not contain a chemical known to the state of California to cause cancer,
reproductive harm or birth defects.
16. OTHER INFORMATION
Copyright 2013 Encapsula NanoSciences LLC license granted to make unlimited paper copies for internal
use only.
The above information is believed to be correct but does not support to be all inclusive and shall be used
only as a guide. The information in this document is based on the present state of our knowledge and is
applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Encapsula NanoSciences LLC shall not be held liable for any
damage resulting from handling or from contact with the above product.

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MSDS for Doxorubicin Solution used for Remote Loading of Non-PEGylated liposomes(DS)

  • 1. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 1. PRODUCT AND COMPANY IDENTIFICATION Product name: SODIUM CARBONATE (Vial 2 of 3 of a kit) Product Number: SC Brand: DOXOSOME TM /IMMUNODOX TM Company Address: ENCAPSULA NANOSCIENCES LLC 6 CADILLAC DRIVE SUITE 245 BRENTWOOD, TN, 37027 Technical Phone: 615-884-4442 Fax: 615-250-8747 Emergency Phone: 615-438-8553 2. COMPOSITION/INFORMATION ON INGREDIENTS Ingredient Name CAS# Percent WATER 7732-18-5 >90 SODIUM CARBONATE 497-19-8 <5 3. HAZARDS IDENTIFCATION GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) (Category 2A) Eye Irritant, H319 GHS LABEL ELEMENTS, INCLUDING PRECAUTIONARY STATEMENTS Pictogram Signal word: Warning Hazard Statement H319 Causes eye irritation Eye Irrit. Eye Irritation Precautionary Statements P264 Wash skin thoroughly after use. P280 Wear protective gear to cover hands, eyes, and face. P305, P351, P338 If exposed to eyes: Rinse with water for several minutes. If wearing contacts, remove them if possible and continue to rinse eyes thoroughly
  • 2. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 P337, P313 If eye irritation persists seek medical attention HMIS RATING HEALTH HAZARDS: 2 FLAMMABILITY: 0 CHRONIC HEALTH HAZARDS: PHYSICAL HAZARDS: 0 NFPA RATING HEALTH HAZARD: 2 FLAMMABILTY: 0 REACTIVITY: 0 POTENTIAL HEALTH EFFECTS Eyes Will cause eye irritation. 4. FIRST AID MEASURES ORAL EXPOSURE Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Consult a physician. DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water. Contact a physician. EYE EXPOSURE In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes. Contact a physician. 5. FIRE FIGHTING MEASURES FLAMMABILITY Not flammable or combustible EXTINGUISHING MEDIA It is suitable to use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. SPECIAL PROCTECTIVE EQUIPMENT FOR FIRE-FIGHTERS Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
  • 3. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 HAZARDOUS COMBUSTION PRODUCTS Hazardous decomposition products formed under fire conditions. Carbon oxides, sodium oxides 6. ACCIDENTAL RELEASE MEASURES METHODS FOR CLEANING UP Absorb any spilled material quickly using absorbent pads. Apply bleach to the affected area and let sit for several hours. Clean the affected area thoroughly with soap and water to remove the bleach. Collect all clean up materials and dispose of them in accordance with local, state and federal waste disposal laws. ENVIRONMENTAL PRECAUTIONS Do not let product enter drains. If safe to do so prevent further leakages or spills. PERSONAL PRECAUTIONS Use personal protective equipment. Avoid breathing in vapors, dust, mist or gas. Ensure adequate ventilation. Prepare evacuation sites. 7. HANDLING AND STORAGE HANDLING User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing. Wash hands thoroughly after handling. STORAGE Suitable: Keep tightly container closed. Store in temperature between approximately 2-8 o C. Do not freeze. Product is sensitive to moisture and light. 8. EXPOSURE CONTROLS/ PERSONAL PROTECTION ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where protection is desired, may use a respirator type P95 (US) or P1 (EU EN 143) for higher level protection use OV/AG/P99 (US) or type ABEK-P2 (EU EN 143). Hand: Compatible chemical-resistant gloves. Dispose of gloves with proper technique to avoid skin contact. Recommended material is nitrile rubber with a thickness of 0.11mm. Eye: Chemical safety goggles with side shades conforming to EN166 (EU) or NIOSH (US).
  • 4. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 Skin and Body: Wear a complete suit protecting against chemicals. GENERAL HYGIENE MEASURES Wash hands thoroughly after handling. Wash contaminated clothing before reuse. Prepare all materials under the fume hood and avoid generating aerosols. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance translucent Safety data pH 11.4 Melting point N/A Boiling point N/A Flash point N/A Ignition Temperature N/A Lower explosion limit N/A Upper Explosion limit N/A Water Solubility Soluble Density N/A 10. STABILITY AND REACITIVITY STORAGE STABILITY Store under recommended conditions. MATERIALS TO AVIOD Strong acids HAZARDOUS DECOMPOSITION PRODUCTS Hazardous decomposition products formed under fire conditions- Carbon oxides, Sodium oxides CONDITIONS TO AVOID Exposure to moisture
  • 5. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 11. TOXICOLOGICAL INFORMATION CARCINOGENICITY This product contains a component that has been reported to be carcinogenic based on its IARC, OHSA, ACGIH, NTP, or EPA classification. IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the IARC. OHSA: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the OHSA. ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the ACGIH. NTP: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the EPA. ACUTE TOXICITY no data available ROUTE OF EXPOSURE Skin Contact: May cause skin irritation Skin Absorption: no data available Eye Contact: May Cause eye irritation Inhalation: no data available Ingestion: no data available SIGNS AND SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. ADDITIONAL INFORMATION RTECS: VZ4050000 burning sensation, cough, wheezing, laryngitis, shortness of breath, headache, nausea, vomiting 12. ECOLOGICAL INFORMATION Elimination information (persistence and degradability) N/A Ecotoxicity effects N/A Further information on ecology N/A
  • 6. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 13. DISPOSAL CONSIDERATIONS PRODUCT Observe all federal, state, and local environment regulations. Contact a licensed professional waste disposal service to remove this material. CONTAMINATED PACKAGING Dispose of as unused product. 14. TRANSPROT INFORMATION DOT (US) Not dangerous goods IMDG Not dangerous goods IATA Not dangerous goods 15. REGULATORY INFORMATION SARA 302 COMPONENTS SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302 SARA 313 COMPONENTS SARA 313: This material does not contain any chemical components with known CAS numbers that exceed threshold (De Minimis) reporting levels established be SARA Title III, Section 313 SARA 311/312 HAZARDS Acute health hazards MASSACHUSETTS RIGHT TO KNOW COMPONENTS No components are subject to the Massachusetts Right to Know Act PENNSYVANIA RIGHT TO KNOW COMPONENTS CAS-No. Revision Date Sodium Carbonate 497-19-8 Water 7732-18-5 NEW JERSEY RIGHT TO KNOW COMPONENTS CAS-No. Revision Date Sodium Carbonate 497-19-8 Water 7732-18-5
  • 7. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 CALIFORNIA PROP. 65 COMPONENTS This product does not contain a chemical known to the state of California to cause cancer, reproductive harm or birth defects. 16. OTHER INFORMATION Copyright 2013 Encapsula NanoSciences LLC license granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not support to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Encapsula NanoSciences LLC shall not be held liable for any damage resulting from handling or from contact with the above product.