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Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
1. PRODUCT AND COMPANY IDENTIFICATION
Product name: IMMUNODOX
TM
-NP- PDP (Vial 1 of 3)
Product Number: IMD-NP-5006
Brand: IMMUNODOXTM
Company Address: ENCAPSULA NANOSCIENCES LLC
6 CADILLAC DRIVE SUITE 245
BRENTWOOD, TN, 37027
Technical Phone: 615-884-4442
Fax: 615-250-8747
Emergency Phone: 615-438-8553
2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient Name CAS# Percent
Water 7732-18-5 >90
Sodium Dihydrogen Citrate 18996-35-5 <5
L-α-phosphatidylcholine 97281-44-2 <5
cholesterol 57-88-5 <5
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] (sodium
salt)
474944-13-3 <5
3. HAZARDS IDENTIFCATION
OSHA
No known OSHA hazards
GHS LABEL ELEMENTS, INCLUDING PRECAUTIONARY STATEMENTS
Not a hazardous substance or mixture.
HMIS RATING
HEALTH HAZARDS: 0
FLAMMABILITY: 0
CHRONIC HEALTH HAZARDS: 0
PHYSICAL HAZARDS: 0
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
NFPA RATING
HEALTH HAZARD: 0
FLAMMABILTY: 0
REACTIVITY: 0
4. FIRST AID MEASURES
ORAL EXPOSURE
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
oxygen. Consult a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious amounts of water. Contact a
physician.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.
5. FIRE FIGHTING MEASURES
FLAMMABILITY
Not flammable or combustible
EXTINGUISHING MEDIA
It is suitable to use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE
No data available
SPECIAL PROCTECTIVE EQUIPMENT FOR FIRE-FIGHTERS
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and
eyes.
FURTHER INFORMATION
No data available
6. ACCIDENTAL RELEASE MEASURES
METHODS FOR CLEANING UP
Absorb any spilled material quickly using absorbent pads. Wipe area to remove as much of the
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
liquid as possible. Apply bleach to the affected area and let sit for several hours. Clean the affected
area thoroughly with soap and water to remove the bleach. Keep in suitable closed container.
Collect all clean up materials and dispose of them in accordance with local, state and federal waste
disposal laws.
ENVIRONMENTAL PRECAUTIONS
Do not let product enter drains. If safe to do so prevent further leakages or spills.
PERSONAL PRECAUTIONS
Use personal protective equipment. Avoid breathing in vapors, mist or gas. Ensure adequate
ventilation. Prepare evacuation sites.
7. HANDLING AND STORAGE
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing. Wash hands
thoroughly after handling.
STORAGE
Suitable: Keep tightly container closed in a well-ventilated area. Store in temperature between
approximately 2-8
o
C. Do not freeze. Product is sensitive to carbon dioxide and oxygen.
SPECIFIC END USES
Can only be used by a scientist in a laboratory setting as a reagent for research purposes
8. EXPOSURE CONTROLS/ PERSONAL PROTECTION
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required. Handle in accordance with good
industrial hygiene and safety practices. Wash hands before breaks and at the end of the workday.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU). Where protection is desired, use full face respirator type
N100 (US) or type P3 (EN 143) as back up to engineering controls. Where risk assessment show sir-
purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US)
or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
Eye: Chemical safety goggles with side shades conforming to EN166. Use equipment tested and
approved under appropriate government standards NIOSH (US) or EN 166(EU).
Skin and Body: Wear a complete suit protecting against chemicals. Use the proper glove removal
technique to avoid contact with material and dispose of contaminated gloves. The type of
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
protective clothing must be chosen based on the concentration and amount of dangerous
substances at the specific work place.
GENERAL HYGIENE MEASURES
Wash hands thoroughly after handling. Wash contaminated clothing before reuse. Prepare all
materials under the fume hood and avoid generating aerosols.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
opaque, translucent
Safety data
pH 4.0
Odor
N/A
Odor Threshold
N/A
Melting point/Freezing point
N/A
Boiling point
N/A
Flash point
N/A
Ignition Temperature
N/A
Lower explosion limit
N/A
Upper Explosion limit
N/A
Water Solubility
N/A
Density
N/A
Evaporation Rate
N/A
Flammability
N/A
Vapor Pressure
N/A
Decomposition
N/A
Viscosity
N/A
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
Explosive Properties
N/A
Oxidizing Properties
N/A
10. STABILITY AND REACITIVITY
STORAGE STABILITY
Store under recommended conditions where it will remain stable (2-8
o
C).
MATERIALS TO AVIOD
Strong oxidizing agents
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous decomposition products formed under fire conditions- Carbon oxides
CONDITIONS TO AVOID
Light and exposure to moisture.
11. TOXICOLOGICAL INFORMATION
CARCINOGENICITY
IARC: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the IARC.
OHSA: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the OHSA.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the ACGIH.
EPA: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by the EPA.
ACUTE TOXICITY
No information available
ROUTE OF EXPOSURE
Skin Contact: N/A
Skin Absorption: N/A
Eye Contact: N/A
Inhalation: N/A
Ingestion: N/A
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
12. ECOLOGICAL INFORMATION
Elimination information (persistence and degradability)
N/A
Ecotoxicity effects
N/A
Further information on ecology
N/A
13. DISPOSAL CONSIDERATIONS
PRODUCT
Observe all federal, state, and local environment regulations. Contact a licensed professional waste
disposal service to remove this material.
CONTAMINATED PACKAGING
Dispose of as unused product.
14. TRANSPROT INFORMATION
DOT (US)
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods
15. REGULATORY INFORMATION
OSHA HAZARDS
No OSHA hazards
SARA 302 COMPONENTS
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title
III, Section 302
SARA 313 COMPONENTS
SARA 313: This material does not contain any chemical components with known CAS numbers
that exceed threshold (De Minimis) reporting levels established be SARA Title III, Section 313
SARA 311/312 HAZARDS
Acute health hazards
Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
MASSACHUSETTS RIGHT TO KNOW COMPONENTS
No components are subject to the Massachusetts Right to Know Act
PENNSYVANIA RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
Water 7732-18-5
Sodium hydroxide 1310-73-2
cholesterol 57-88-5
L-α-phosphatidylcholine 97281-44-2
Sodium dihydrogen citrate 18969-35-5
NEW JERSEY RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
Water 7732-18-5
Sodium dihydrogen citrate 18969-35-5
cholesterol 57-88-5
L-α-phosphatidylcholine 97281-44-2
CALIFORNIA PROP. 65 COMPONENTS
This product does not contain any chemicals known to the State of California to cause cancer,
birth defects, or any other reproductive harm.
16. OTHER INFORMATION
Copyright 2013 Encapsula NanoSciences LLC license granted to make unlimited paper copies for internal
use only.
The above information is believed to be correct but does not support to be all inclusive and shall be used
only as a guide. The information in this document is based on the present state of our knowledge and is
applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Encapsula NanoSciences LLC shall not be held liable for any
damage resulting from handling or from contact with the above product.

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MSDS for Non-PEGylated liposomes containing PDP lipid for conjugation_IMMUNODOX_PDP (IMD-5006)

  • 1. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 1. PRODUCT AND COMPANY IDENTIFICATION Product name: IMMUNODOX TM -NP- PDP (Vial 1 of 3) Product Number: IMD-NP-5006 Brand: IMMUNODOXTM Company Address: ENCAPSULA NANOSCIENCES LLC 6 CADILLAC DRIVE SUITE 245 BRENTWOOD, TN, 37027 Technical Phone: 615-884-4442 Fax: 615-250-8747 Emergency Phone: 615-438-8553 2. COMPOSITION/INFORMATION ON INGREDIENTS Ingredient Name CAS# Percent Water 7732-18-5 >90 Sodium Dihydrogen Citrate 18996-35-5 <5 L-α-phosphatidylcholine 97281-44-2 <5 cholesterol 57-88-5 <5 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] (sodium salt) 474944-13-3 <5 3. HAZARDS IDENTIFCATION OSHA No known OSHA hazards GHS LABEL ELEMENTS, INCLUDING PRECAUTIONARY STATEMENTS Not a hazardous substance or mixture. HMIS RATING HEALTH HAZARDS: 0 FLAMMABILITY: 0 CHRONIC HEALTH HAZARDS: 0 PHYSICAL HAZARDS: 0
  • 2. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 NFPA RATING HEALTH HAZARD: 0 FLAMMABILTY: 0 REACTIVITY: 0 4. FIRST AID MEASURES ORAL EXPOSURE Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Consult a physician. DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water. Contact a physician. EYE EXPOSURE In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes. 5. FIRE FIGHTING MEASURES FLAMMABILITY Not flammable or combustible EXTINGUISHING MEDIA It is suitable to use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE No data available SPECIAL PROCTECTIVE EQUIPMENT FOR FIRE-FIGHTERS Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. FURTHER INFORMATION No data available 6. ACCIDENTAL RELEASE MEASURES METHODS FOR CLEANING UP Absorb any spilled material quickly using absorbent pads. Wipe area to remove as much of the
  • 3. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 liquid as possible. Apply bleach to the affected area and let sit for several hours. Clean the affected area thoroughly with soap and water to remove the bleach. Keep in suitable closed container. Collect all clean up materials and dispose of them in accordance with local, state and federal waste disposal laws. ENVIRONMENTAL PRECAUTIONS Do not let product enter drains. If safe to do so prevent further leakages or spills. PERSONAL PRECAUTIONS Use personal protective equipment. Avoid breathing in vapors, mist or gas. Ensure adequate ventilation. Prepare evacuation sites. 7. HANDLING AND STORAGE HANDLING User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing. Wash hands thoroughly after handling. STORAGE Suitable: Keep tightly container closed in a well-ventilated area. Store in temperature between approximately 2-8 o C. Do not freeze. Product is sensitive to carbon dioxide and oxygen. SPECIFIC END USES Can only be used by a scientist in a laboratory setting as a reagent for research purposes 8. EXPOSURE CONTROLS/ PERSONAL PROTECTION ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required. Handle in accordance with good industrial hygiene and safety practices. Wash hands before breaks and at the end of the workday. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where protection is desired, use full face respirator type N100 (US) or type P3 (EN 143) as back up to engineering controls. Where risk assessment show sir- purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. Eye: Chemical safety goggles with side shades conforming to EN166. Use equipment tested and approved under appropriate government standards NIOSH (US) or EN 166(EU). Skin and Body: Wear a complete suit protecting against chemicals. Use the proper glove removal technique to avoid contact with material and dispose of contaminated gloves. The type of
  • 4. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 protective clothing must be chosen based on the concentration and amount of dangerous substances at the specific work place. GENERAL HYGIENE MEASURES Wash hands thoroughly after handling. Wash contaminated clothing before reuse. Prepare all materials under the fume hood and avoid generating aerosols. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance opaque, translucent Safety data pH 4.0 Odor N/A Odor Threshold N/A Melting point/Freezing point N/A Boiling point N/A Flash point N/A Ignition Temperature N/A Lower explosion limit N/A Upper Explosion limit N/A Water Solubility N/A Density N/A Evaporation Rate N/A Flammability N/A Vapor Pressure N/A Decomposition N/A Viscosity N/A
  • 5. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 Explosive Properties N/A Oxidizing Properties N/A 10. STABILITY AND REACITIVITY STORAGE STABILITY Store under recommended conditions where it will remain stable (2-8 o C). MATERIALS TO AVIOD Strong oxidizing agents HAZARDOUS DECOMPOSITION PRODUCTS Hazardous decomposition products formed under fire conditions- Carbon oxides CONDITIONS TO AVOID Light and exposure to moisture. 11. TOXICOLOGICAL INFORMATION CARCINOGENICITY IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the IARC. OHSA: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the OHSA. ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the ACGIH. EPA: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by the EPA. ACUTE TOXICITY No information available ROUTE OF EXPOSURE Skin Contact: N/A Skin Absorption: N/A Eye Contact: N/A Inhalation: N/A Ingestion: N/A
  • 6. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 12. ECOLOGICAL INFORMATION Elimination information (persistence and degradability) N/A Ecotoxicity effects N/A Further information on ecology N/A 13. DISPOSAL CONSIDERATIONS PRODUCT Observe all federal, state, and local environment regulations. Contact a licensed professional waste disposal service to remove this material. CONTAMINATED PACKAGING Dispose of as unused product. 14. TRANSPROT INFORMATION DOT (US) Not dangerous goods IMDG Not dangerous goods IATA Not dangerous goods 15. REGULATORY INFORMATION OSHA HAZARDS No OSHA hazards SARA 302 COMPONENTS SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302 SARA 313 COMPONENTS SARA 313: This material does not contain any chemical components with known CAS numbers that exceed threshold (De Minimis) reporting levels established be SARA Title III, Section 313 SARA 311/312 HAZARDS Acute health hazards
  • 7. Material Safety Data Sheet Version 1.1 Revision Date: 06/05/2014 Print Date: 08/06/2014 MASSACHUSETTS RIGHT TO KNOW COMPONENTS No components are subject to the Massachusetts Right to Know Act PENNSYVANIA RIGHT TO KNOW COMPONENTS CAS-No. Revision Date Water 7732-18-5 Sodium hydroxide 1310-73-2 cholesterol 57-88-5 L-α-phosphatidylcholine 97281-44-2 Sodium dihydrogen citrate 18969-35-5 NEW JERSEY RIGHT TO KNOW COMPONENTS CAS-No. Revision Date Water 7732-18-5 Sodium dihydrogen citrate 18969-35-5 cholesterol 57-88-5 L-α-phosphatidylcholine 97281-44-2 CALIFORNIA PROP. 65 COMPONENTS This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm. 16. OTHER INFORMATION Copyright 2013 Encapsula NanoSciences LLC license granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not support to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Encapsula NanoSciences LLC shall not be held liable for any damage resulting from handling or from contact with the above product.